WorldCat Identities

Südhof, Thomas C.

Overview
Works: 18 works in 46 publications in 1 language and 1,101 library holdings
Genres: Conference papers and proceedings  Filmed lectures  Nonfiction films 
Roles: Editor, Author, Thesis advisor
Publication Timeline
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Most widely held works about Thomas C Südhof
 
Most widely held works by Thomas C Südhof
Pharmacology of neurotransmitter release by Thomas C Südhof( )

14 editions published between 2007 and 2008 in English and held by 501 WorldCat member libraries worldwide

It has been known for half a century that neurotransmitters are released in preformed quanta, that the quanta represent transmitter-storing vesicles, and that release occurs by exocytosis. The focus of this book is twofold. In the first part, the molecular events of exocytosis are analysed. This includes a discussion of presynaptic calcium channels, the core proteins of the secretory machinery, and the actions of clostridial toxins and a -latrotoxin, famous for their potency as well as their crucial role in the elucidation of the steps of exocytosis. In the book??'s second part, the presynapti
Synapses( Book )

11 editions published between 2001 and 2003 in English and held by 456 WorldCat member libraries worldwide

"This volume provides a comprehensive and authoritative overview of a century of research on synaptic structure and function culminating in the most recent work. Written by leading experts in the field, Synapses will be of interest to a broad range of neuroscientists, including those studying the cellular and molecular mechanisms of synaptic transmission, learning and memory, neuronal plasticity, neurotransmitters, and synaptic morphology. It will also be an essential reference for students and biomedical professionals in all areas of neuroscience."--Jacket
The synapse : a subject collection from Cold Spring Harbor perspectives in biology( Book )

5 editions published in 2012 in English and held by 111 WorldCat member libraries worldwide

Abstracts of papers presented at the 2007 meeting on synapses : from molecules to circuits & behavior : April 18-April 22, 2006( Book )

2 editions published in 2007 in English and held by 11 WorldCat member libraries worldwide

Abstracts of papers presented at the 2009 meeting on synapses : from molecules to circuits & behavior, April 14-April 18, 2009( Book )

1 edition published in 2009 in English and held by 6 WorldCat member libraries worldwide

Abstracts of papers presented at the 2011 meeting on synapses : from molecules to circuits & behavior, April 12-April 16, 2011 by Meeting on Synapses( Book )

1 edition published in 2011 in English and held by 3 WorldCat member libraries worldwide

Building a synapse : from extracellular cues to intracellular proteins by Poh Hui Chia( )

1 edition published in 2013 in English and held by 2 WorldCat member libraries worldwide

Nervous system function, from sensory perception to motor control, requires precisely patterned networks of synaptic connections. Each synapse is the fundamental unit of connection and proper establishment of this complex structure is essential for cognitive processes. Therefore, elucidating the molecular mechanisms and characterizing the proteins important for the development and structural organization of a synapse is fundamental to our understanding of the brain. Using C. elegans, I have explored the process of presynaptic development for my thesis work. I demonstrate that specification and initiation of synapse formation by clustering of SYG-1/Neph and SYG-2/Nephrin, two immunoglobulin superfamily transmembrane proteins, is dependent on their cell adhesion strength and interaction topology during development. Once this extracellular instructive cue is established at nascent synapses, an Arp2/3 dependent actin cytoskeleton is built locally that is dependent on the WVE-1/WAVE regulatory complex (WRC). This is mediated by interaction between a WRC interacting receptor sequence (WIRS) motif on the intracellular tail of SYG-1, which recruits the WRC. Next, an adaptor protein NAB-1/Neurabin binds to F-actin and recruits active zone proteins, SYD-1 and SYD-2/Liprin-[alpha] by forming a tripartite complex. SYD-2/Liprin-[alpha] is a key scaffold protein that interacts with multiple active zone components including UNC-10/Rim, ERC/ELKS-1, and GIT to form the synaptic active zone. SYD-2/Liprin-[alpha]'s pro-synaptogenic function can be regulated by interaction between its N-terminal coiled-coil domains and C-terminal sterile alpha motif (SAM) domains. Taken together, this insight into how synapses assemble in a simpler organism may lead to better understanding of development and function of the mammalian brain and its dysfunction in disease
Anatomical and Behavioral Investigation of C1ql3 in the Mouse Suprachiasmatic Nucleus( )

in English and held by 1 WorldCat member library worldwide

Many biochemical, physiological, and behavioral processes such as glucose metabolism, body temperature, and sleep-wake cycles show regular daily rhythms. These circadian rhythms are adjusted to the environmental light-dark cycle by a central pacemaker located in the suprachiasmatic nucleus (SCN) in order for the processes to occur at appropriate times of day. Here, we investigated the expression and function of a synaptic organizing protein, C1QL3, in the SCN. We found that C1ql3 is robustly expressed in the SCN. C1ql3 knockout mice have a reduced density of excitatory synapses in the SCN. In addition, these mice exhibited less consolidated activity to the active portions of the day and period lengthening following a 15-minute phase-delaying light pulse. These data identify C1QL3 as a signaling molecule that is highly expressed in SCN neurons, where it contributes to the formation and/or maintenance of glutamatergic synapses and plays a role in circadian behaviors, which may include circadian aftereffects
Presynaptic mechanisms of neurotransmission( Book )

1 edition published in 1995 in English and held by 1 WorldCat member library worldwide

Towards a molecular definition of synapse formation : neurexins, neuroligins and more by Thomas C Südhof( Visual )

1 edition published in 2014 in English and held by 1 WorldCat member library worldwide

2013 Nobel Laureate in Physiology or Medicine Prof Thomas Südhof shares his research on synaptic cell-adhesion molecules, in particular neurexins and neuroligins that are essential components of synapses. He presents how these molecules, and their many intra- and extracellular binding partners, shape the properties of synapses, such that their function is among the key determinants for the formation and specification of synapses
Mouse genetic approaches to studying functionally defined neural circuits and neurodevelopmental disorders by Casey Jack Guenthner( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Over the past several decades, the study of neurobiology has been revolutionized by the development of increasingly sophisticated genetic methods in diverse model organisms. The mouse is the most easily genetically manipulated mammal and has become a favorite model organism for neurobiologists. In two independent projects, I have developed a new method--Targeted Recombination in Active Populations (TRAP)--to facilitate studies of neural circuits in genetically modified mice and have developed and characterized new mouse models of a human neurodevelopmental condition, Smith-Magenis Syndrome. In many brain regions, functionally distinct populations of neurons are intermingled and genetically indistinguishable using current methods. The ability to selectively genetically manipulate such functionally distinct neuronal populations would facilitate experiments to address many outstanding questions in neurobiology. To enable selective genetic access to functionally defined neural circuits, I developed TRAP. This novel method utilizes mice in which the tamoxifen-dependent Cre recombinase CreER has been knocked-in to the loci of the immediate early genes (IEGs) Arc and Fos. Because IEGs are expressed in response to neuronal or synaptic activity, CreER is expressed in an activity-dependent manner in these mice. In the presence of tamoxifen, active neurons that express CreER can undergo a CreER-catalyzed recombination event, while inactive neurons, which do not express CreER, do not undergo recombination; in the absence of tamoxifen, CreER remains inactive. By combining the Arc-CreER and Fos-CreER alleles with transgenes that allow Cre-dependent expression of genetically encoded tools, TRAP enables the selective genetic manipulation of neurons activated during a time window surrounding tamoxifen injection. I characterized this novel method and demonstrate its utility in multiple neural systems--including in the somatosensory, visual, auditory, and hippocampal space representation systems. In a separate project, I began to dissect the function of a gene--Retinoic acid-induced 1 (Rai1)--involved in a rare human neurodevelopmental disorder, Smith-Magenis Syndrome (SMS). Human genetics studies have shown that SMS, which is characterized by general cognitive, motor, and developmental delay in addition to autistic features, behavioral problems, and numerous other multisystemic abnormalities, is caused by haploinsufficiency of RAI1. However, the function of Rai1 in the developing and adult brain and how its disruption leads to the symptoms of SMS are unclear. I found that Rai1 is expressed widely but not ubiquitously throughout the brain in both neurons and astrocytes. To better understand the function of Rai1 and the pathogenic mechanism of SMS, I generated an allele of Rai1 that can be conditionally inactivated in the presence of Cre recombinase. Using this allele, I generated mice in which Rai1 was selectively deleted in different cell types in the brain. I found that global homozygous deletion of Rai1 (using Nestin-Cre) results in lethality in early adulthood, fear learning and motor deficits, and obesity. The fear learning deficit was also apparent in mice lacking Rai1 specifically in inhibitory neurons (using GAD2-Cre). Loss of Rai1 from forebrain excitatory neurons (using Emx1-Cre) and from astrocytes and postnatally born neurons (using mGFAP-Cre) did not produce any phenotypes detectable in our behavioral assays. Using Mosaic Analysis with Double Markers (MADM), I generated mice in which Rai1 was deleted in only a subpopulation of distinctly labeled cells in the brains of otherwise Rai1 heterozygous mice. In Rai1 MADM mice, I observed that Rai1-null Bergmann glia--a specialized cerebellar astrocyte type--are present in fewer numbers than Rai1-wild-type Bergmann glia, suggesting a role for Rai1 in the production or survival of this cell type. Although much more work is needed to understand the function of Rai1 and how its loss leads to SMS, these data suggest some useful starting points for future studies
Functional dissection of the Cbln family of synaptic cell-adhesion molecules by Erica Michelle Seigneur( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Precise control of synapse formation and specification is required for the normal development and functioning of neural networks, and consequently, for cognition, emotion, and behavior. Trans-synaptic cell-adhesion molecules are understood to play an essential role in the formation, specification, and functioning of synapses. Cerebellins are a family of secreted proteins (Cbln1-Cbln4) that act as trans-synaptic cell-adhesion molecules by binding to presynaptic neurexins and postsynaptic receptors. In the cerebellum, Cbln1 is secreted from presynaptic granule cells and functions as a trans-synaptic organizer of parallel fiber-Purkinje cell synapses. Although the essential function of Cbln1 in cerebellar parallel-fiber synapses is well studied, little is known about the function of cerebellins outside the cerebellum and even less is known about the function of Cbln2 and Cbln4. In this dissertation, I will address these issues by using a combination of techniques to systematically dissect the expression profile and function of Cbln1, Cbln2, and Cbln4 throughout the brain. Taken together, I will show that all three cerebellins contribute to brain function, and that cerebellins act as important synaptic organizers in specific subsets of neurons throughout the brain
Molecular physiology of neurotransmitter release by Thomas C Südhof( Visual )

1 edition published in 2009 in English and held by 1 WorldCat member library worldwide

(CIT): My laboratory studies how calcium triggers neurotransmitter release, and how it regulates release during synaptic plasticity. In my talk, I will present recent data describing the properties of the calcium sensors mediating the triggering of release and its regulation during presynaptic plasticity. I will also show results explaining their mechanism of action, at least in part, and try to describe how the combined actions of multiple molecules converges to achieve the unusual speed and precision with which neurotransmitter release occurs
The molecular logic of synapse formation in the brain( Visual )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

(CIT): NIH Director's Wednesday Afternoon Lecture Series Dr. Thomas C. Sudhof shared the 2013 Nobel Prize in Physiology or Medicine (with James Rothman and Randy Schekman) for "discoveries of machinery regulating vesicle traffic, a major transport system in our cells." His current work focuses on the organization of the trans-synaptic signaling machinery that enables synapse formation and specifications as well as synaptic plasticity during development and throughout life. He and his lab members hypothesize that the number, location, and properties of synapses are determined by interactions between presynaptic and postsynaptic cell-surface recognition molecules and/or signaling molecules. They refer to the rules by which these molecules construct circuits as the molecular logic of neural circuits. Several cell-surface and signaling molecules contributing to the molecular logic of neural circuits have been characterized, most prominently presynaptic neurexin cell-adhesion molecules and their various ligands. Although neuropsychiatric disorders such as autism and schizophrenia have high incidence rates, they are poorly understood. Recent advances in sequencing technologies, however, have identified mutations in a large number of genes that predispose to autism and schizophrenia. No common theme unites the affected genes, but a subset of them encodes proteins--including notably the neurexins--that function at the synapse. Dr. Sudhof thus further hypothesizes that at least a subset of autism and schizophrenia syndromes are produced by impairments in the molecular logic of neural circuits: The input/output relations in particular circuits are shifted, but not blocked, and skew the brain's information-processing capacity for a selected set of tasks. In support of this hypothesis, his lab observed that specific autism- and schizophrenia-associated gene mutations in neurexins and their ligands cause selective alterations in a subset of synapses and circuits that induce discrete specific behavioral abnormalities. The lab's analysis of the molecular logic of neural circuits and their impairment in neuropsychiatric disorders has only begun. But the conceptual framework that has been outlined might allow a better understanding of how the brain processes information and of how such information processing becomes altered in autism and schizophrenia. For his presentation, Dr. Sudhof will describe his lab's work on testing the hypotheses inherent in this conceptual framework, focusing on families of synaptic cell-adhesion molecules such as neurexins and latrophilins. Although incomplete, the studies that he will describe have already led to surprising conclusions about how neural circuits are organized and provide a perspective for future work
Neuropharmacology III : Symposium : Selected preprints( Book )

1 edition published in 1995 in English and held by 1 WorldCat member library worldwide

Handbuch der experimentellen Pharmakologie : Handbook of experimental pharmacology( Book )

in English and held by 0 WorldCat member libraries worldwide

A transcriptively active complex of APP with Fe65 and histone acetyltransferase tip60 by Xinwei Cao( )

1 edition published in 2001 in English and held by 0 WorldCat member libraries worldwide

 
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Pharmacology of neurotransmitter release
Covers
Synapses
Alternative Names
Südhof, Thomas Christian

Südhof, Thomas Christian 1955-

Thomas C. Südhof biólogo, neurólogo e investigador científico

Thomas C. Südhof biologo tedesco

Thomas C. Südhof dokter asal Amerika Serikat

Thomas C. Südhof German biochemist

Thomas C. Südhof tysk-amerikansk biokemiker

Thomas Christian Südhof

Thomas Südhof

Thomas Südhof biochimiste allemand

Thomas Südhof biologo tedesco

Thomas Südhof deutsch-amerikanischer Biochemiker

Thomas Südhof Duits biochemicus

Thomas Südhof tysk biokjemiker

Зюдхоф, Томас Кристиан немецкий нейробиолог

Томас Зидхоф

Томас Зюдаў

Томас Зюдгоф німецький біохімік і нейробіолог, лауреат Нобелівської премії

Томас Зюдхоф

Томас Кристиан Зюдхоф

תומאס סודהוף

תומאס סודהוף ביוכימאי גרמני-אמריקאי

توماس زودهوف

توماس سودهوف

تھامس سڈہوف

تھامس سی. سڈہوف

थॉमस सुडॉफ

থমাস ক্রিশ্চিয়ান সুদোফ

தாமஸ் சி. சுதோப்

තෝමස් සී. සූඩ්හෝෆ්

토마스 쥐트호프

トーマス・スードフ

托马斯·聚德霍夫

Languages
English (46)