WorldCat Identities

Südhof, Thomas C.

Overview
Works: 13 works in 33 publications in 1 language and 1,029 library holdings
Genres: Conference proceedings 
Roles: Editor, Thesis advisor
Classifications: QP364, 612.8
Publication Timeline
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Publications about  Thomas C Südhof Publications about Thomas C Südhof
Publications by  Thomas C Südhof Publications by Thomas C Südhof
Most widely held works by Thomas C Südhof
Pharmacology of neurotransmitter release by Thomas C Südhof ( )
12 editions published between 2007 and 2008 in English and held by 466 WorldCat member libraries worldwide
It has been known for half a century that neurotransmitters are released in preformed quanta, that the quanta represent transmitter-storing vesicles, and that release occurs by exocytosis. The focus of this book is twofold. In the first part, the molecular events of exocytosis are analysed. This includes a discussion of presynaptic calcium channels, the core proteins of the secretory machinery, and the actions of clostridial toxins and a -latrotoxin, famous for their potency as well as their crucial role in the elucidation of the steps of exocytosis. In the book??'s second part, the presynapti
Synapses ( Book )
8 editions published between 2001 and 2003 in English and held by 448 WorldCat member libraries worldwide
"This volume provides a comprehensive and authoritative overview of a century of research on synaptic structure and function culminating in the most recent work. Written by leading experts in the field, Synapses will be of interest to a broad range of neuroscientists, including those studying the cellular and molecular mechanisms of synaptic transmission, learning and memory, neuronal plasticity, neurotransmitters, and synaptic morphology. It will also be an essential reference for students and biomedical professionals in all areas of neuroscience."--Jacket
The synapse : a subject collection from Cold Spring Harbor perspectives in biology ( Book )
3 editions published in 2012 in English and held by 90 WorldCat member libraries worldwide
Abstracts of papers presented at the 2007 meeting on synapses : from molecules to circuits & behavior : April 18-April 22, 2006 ( Book )
1 edition published in 2007 in English and held by 8 WorldCat member libraries worldwide
Abstracts of papers presented at the 2009 meeting on synapses : from molecules to circuits & behavior, April 14-April 18, 2009 ( Book )
1 edition published in 2009 in English and held by 6 WorldCat member libraries worldwide
Abstracts of papers presented at the 2011 meeting on synapses : from molecules to circuits & behavior, April 12-April 16, 2011 by Meeting on Synapses ( Book )
1 edition published in 2011 in English and held by 3 WorldCat member libraries worldwide
The synapse ( Book )
1 edition published in 2012 in English and held by 3 WorldCat member libraries worldwide
Abstracts of papers presented at the 2007 meeting on synapses : from molecules to circuits & behavior : April 18-April 22, 2007 ( Book )
1 edition published in 2007 in English and held by 2 WorldCat member libraries worldwide
Die biophysikalische Struktur der chromaffinen Granula im Lichte ihres Osmometerverhaltens und ihrer osmotischen Lyse by Thomas C Südhof ( Book )
1 edition published in 1982 in Undetermined and held by 1 WorldCat member library worldwide
Building a synapse from extracellular cues to intracellular proteins by Poh Hui Chia ( )
1 edition published in 2013 in English and held by 1 WorldCat member library worldwide
Nervous system function, from sensory perception to motor control, requires precisely patterned networks of synaptic connections. Each synapse is the fundamental unit of connection and proper establishment of this complex structure is essential for cognitive processes. Therefore, elucidating the molecular mechanisms and characterizing the proteins important for the development and structural organization of a synapse is fundamental to our understanding of the brain. Using C. elegans, I have explored the process of presynaptic development for my thesis work. I demonstrate that specification and initiation of synapse formation by clustering of SYG-1/Neph and SYG-2/Nephrin, two immunoglobulin superfamily transmembrane proteins, is dependent on their cell adhesion strength and interaction topology during development. Once this extracellular instructive cue is established at nascent synapses, an Arp2/3 dependent actin cytoskeleton is built locally that is dependent on the WVE-1/WAVE regulatory complex (WRC). This is mediated by interaction between a WRC interacting receptor sequence (WIRS) motif on the intracellular tail of SYG-1, which recruits the WRC. Next, an adaptor protein NAB-1/Neurabin binds to F-actin and recruits active zone proteins, SYD-1 and SYD-2/Liprin-[alpha] by forming a tripartite complex. SYD-2/Liprin-[alpha] is a key scaffold protein that interacts with multiple active zone components including UNC-10/Rim, ERC/ELKS-1, and GIT to form the synaptic active zone. SYD-2/Liprin-[alpha]'s pro-synaptogenic function can be regulated by interaction between its N-terminal coiled-coil domains and C-terminal sterile alpha motif (SAM) domains. Taken together, this insight into how synapses assemble in a simpler organism may lead to better understanding of development and function of the mammalian brain and its dysfunction in disease
Neuropharmacology III : Symposium : Selected preprints ( Book )
1 edition published in 1995 in English and held by 1 WorldCat member library worldwide
Molecular physiology of neurotransmitter release by Thomas C Südhof ( )
1 edition published in 2009 in English and held by 0 WorldCat member libraries worldwide
(CIT): My laboratory studies how calcium triggers neurotransmitter release, and how it regulates release during synaptic plasticity. In my talk, I will present recent data describing the properties of the calcium sensors mediating the triggering of release and its regulation during presynaptic plasticity. I will also show results explaining their mechanism of action, at least in part, and try to describe how the combined actions of multiple molecules converges to achieve the unusual speed and precision with which neurotransmitter release occurs
Handbuch der experimentellen Pharmakologie : Handbook of experimental pharmacology ( Book )
in English and held by 0 WorldCat member libraries worldwide
 
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Alternative Names
Südhof, Thomas C.
Languages
English (32)
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