WorldCat Identities

Maple, Amanda 1956-

Overview
Works: 5 works in 15 publications in 1 language and 742 library holdings
Genres: Bibliography 
Roles: Editor
Classifications: ML113, 016.78026
Publication Timeline
Key
Publications about  Amanda Maple Publications about Amanda Maple
Publications by  Amanda Maple Publications by Amanda Maple
Most widely held works by Amanda Maple
Guide to writing collection development policies for music by Amanda Maple ( Book )
6 editions published in 2001 in English and held by 402 WorldCat member libraries worldwide
Music librarianship at the turn of the century ( Book )
6 editions published between 2000 and 2002 in English and held by 335 WorldCat member libraries worldwide
A basic music library : essential scores and sound recordings by Music Library Association ( Book )
1 edition published in 2013 in English and held by 3 WorldCat member libraries worldwide
Lists 7,000 recordings and 3,000 printed scores coded for different levels of collecting
Cellular mechanisms underlying the effects of repeated D₂-like agonist treatment on prepulse Inhibition by Amanda Maple ( )
1 edition published in 2013 in English and held by 1 WorldCat member library worldwide
Patients with schizophrenia have deficits in sensorimotor gating, the ability to gate out irrelevant stimuli in order to attend to relevant stimuli. Prepulse inhibition (PPI) of the startle response is a reliable and valid model of sensorimotor gating across species. Repeated D₂-like agonist treatment alleviates prior PPI deficits in rats, termed a PPI recovery, and is observable 28 days after treatment. The aim of the current project is to illuminate the underlying mechanism for this persistent change of behavior and determine the clinical relevance of repeated D₂-like agonist treatment. Our results revealed a significant increase in Delta FosB, a transcription factor, in the nucleus accumbens (NAc) 10 days after repeated D₂-like agonist treatment. Additionally, we investigated if Delta FosB was necessary for long-lasting PPI recovery and discovered a bilateral infusion of dominant-negative Delta JunD prevented PPI recovery after repeated D₂-like agonist treatment. To further develop the underlying mechanism of PPI recovery, we observed that dominant negative mutant cyclic adenosine monophosphate (cAMP) response biding element protein (CREB) prevented repeated D₂-like agonist-induced Delta FosB expression in the NAc. We then compared our previous behavioral and intracellular findings to the results of repeated aripiprazole, a novel D₂-like partial agonist antipsychotic, to determine if repeated D₂-like receptor agonist action is a clinically relevant pharmacological approach. As compared to previous PPI recovery and Delta FosB expression after repeated D₂-like agonist treatment, we found similar PPI recovery and Delta FosB expression after repeated aripiprazole treatment in rats. We can conclude that repeated D₂-like agonist treatment produces persistent PPI recovery through CREB phosphorylation and Delta FosB, which is necessary for PPI recovery. Furthermore, this pharmacological approach produces behavioral and intracellular changes similar to an effective novel antipsychotic. These findings suggest the underlying intracellular mechanism for sustained PPI recovery is clinically relevant and may be a potential target of therapeutic intervention to alleviate sensorimotor gating deficits, which are associated with cognitive symptoms of schizophrenia
Digital Music Library : A Course Related Music Service of the Penn State University Libraries and Library Computing Services by Amanda Maple ( )
1 edition published in 1999 in English and held by 1 WorldCat member library worldwide
This service provides Penn State students and instructors access to music being studied in courses at Penn State University. For each selection of music, you have the option of listening via the campus ethernet network at 112K or via dial-up modem at 28K (for use off campus)
 
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.68 (from 0.35 for A basic mu ... to 1.00 for Digital Mu ...)
Languages
English (15)
Covers