WorldCat Identities

Maple, Amanda 1956-

Works: 5 works in 21 publications in 1 language and 913 library holdings
Genres: Bibliography  Bibliographies 
Roles: Editor, Author
Classifications: ML111, 025.288
Publication Timeline
Most widely held works by Amanda Maple
Guide to writing collection development policies for music by Amanda Maple( Book )

7 editions published in 2001 in English and held by 383 WorldCat member libraries worldwide

Music librarianship at the turn of the century( Book )

9 editions published between 2000 and 2002 in English and held by 342 WorldCat member libraries worldwide

A basic music library : essential scores and sound recordings( Book )

3 editions published between 2013 and 2017 in English and held by 140 WorldCat member libraries worldwide

Cellular mechanisms underlying the effects of repeated D₂-like agonist treatment on prepulse Inhibition by Amanda Maple( )

1 edition published in 2013 in English and held by 2 WorldCat member libraries worldwide

Patients with schizophrenia have deficits in sensorimotor gating, the ability to gate out irrelevant stimuli in order to attend to relevant stimuli. Prepulse inhibition (PPI) of the startle response is a reliable and valid model of sensorimotor gating across species. Repeated D₂-like agonist treatment alleviates prior PPI deficits in rats, termed a PPI recovery, and is observable 28 days after treatment. The aim of the current project is to illuminate the underlying mechanism for this persistent change of behavior and determine the clinical relevance of repeated D₂-like agonist treatment. Our results revealed a significant increase in Delta FosB, a transcription factor, in the nucleus accumbens (NAc) 10 days after repeated D₂-like agonist treatment. Additionally, we investigated if Delta FosB was necessary for long-lasting PPI recovery and discovered a bilateral infusion of dominant-negative Delta JunD prevented PPI recovery after repeated D₂-like agonist treatment. To further develop the underlying mechanism of PPI recovery, we observed that dominant negative mutant cyclic adenosine monophosphate (cAMP) response biding element protein (CREB) prevented repeated D₂-like agonist-induced Delta FosB expression in the NAc. We then compared our previous behavioral and intracellular findings to the results of repeated aripiprazole, a novel D₂-like partial agonist antipsychotic, to determine if repeated D₂-like receptor agonist action is a clinically relevant pharmacological approach. As compared to previous PPI recovery and Delta FosB expression after repeated D₂-like agonist treatment, we found similar PPI recovery and Delta FosB expression after repeated aripiprazole treatment in rats. We can conclude that repeated D₂-like agonist treatment produces persistent PPI recovery through CREB phosphorylation and Delta FosB, which is necessary for PPI recovery. Furthermore, this pharmacological approach produces behavioral and intracellular changes similar to an effective novel antipsychotic. These findings suggest the underlying intracellular mechanism for sustained PPI recovery is clinically relevant and may be a potential target of therapeutic intervention to alleviate sensorimotor gating deficits, which are associated with cognitive symptoms of schizophrenia
Digital Music Library : a Course Related Music Service of the Penn State University Libraries and Library Computing Services by Amanda Maple( )

1 edition published in 1999 in English and held by 0 WorldCat member libraries worldwide

This service provides Penn State students and instructors access to music being studied in courses at Penn State University. For each selection of music, you have the option of listening via the campus ethernet network at 112K or via dial-up modem at 28K (for use off campus)
Audience Level
Audience Level
  Kids General Special  
Audience level: 0.50 (from 0.41 for A basic mu ... to 0.79 for Cellular m ...)

WorldCat IdentitiesRelated Identities
English (21)

Music librarianship at the turn of the centuryA basic music library : essential scores and sound recordings