WorldCat Identities
Thu Oct 16 18:03:23 2014 UTClccn-n000671320.35A basic music library : essential scores and sound recordings /0.681.00Digital Music Library : A Course Related Music Service of the Penn State University Libraries and Library Computing Services98031970n 000671325206646lccn-n00077865Morrow, Jean1944-ctblccn-n85258986Griscom, Richardedtlccn-no2004059877Troutman, Leslie Anne1957-2003ctblccn-n91015190Wright, H. Stephenctblccn-no93025175Papakhian, A. Ralph(Arsen Ralph)1948-2010ctblccn-no2004060405Sturm, Georgectblccn-no2004060411Lubrano, Judectblccn-n82076864Druesedow, John E.ctblccn-n81132036Lasocki, Davidctblccn-no2004060401Shepard, John1949-ctbMaple, Amanda1956-BibliographyMusic--Instruction and studyMusicMusic libraries--Collection developmentMusic librarianshipCollection development (Libraries)--Policy statementsUnited StatesDopamine--AgonistsNeurotransmittersSchizophrenia--Treatment195619992000200120022013742515016.78026ML113ocn043978182ocn441673078ocn8071017084026ocn045505971book20010.63Maple, AmandaGuide to writing collection development policies for music+-+01559356353356ocn043978182book20000.74Music librarianship at the turn of the century+-+911383563531ocn845085646book20130.35Music Library AssociationA basic music library : essential scores and sound recordingsBibliographyLists 7,000 recordings and 3,000 printed scores coded for different levels of collecting+-+448564383532411ocn862118177file20131.00Maple, AmandaCellular mechanisms underlying the effects of repeated D₂-like agonist treatment on prepulse InhibitionPatients with schizophrenia have deficits in sensorimotor gating, the ability to gate out irrelevant stimuli in order to attend to relevant stimuli. Prepulse inhibition (PPI) of the startle response is a reliable and valid model of sensorimotor gating across species. Repeated D₂-like agonist treatment alleviates prior PPI deficits in rats, termed a PPI recovery, and is observable 28 days after treatment. The aim of the current project is to illuminate the underlying mechanism for this persistent change of behavior and determine the clinical relevance of repeated D₂-like agonist treatment. Our results revealed a significant increase in Delta FosB, a transcription factor, in the nucleus accumbens (NAc) 10 days after repeated D₂-like agonist treatment. Additionally, we investigated if Delta FosB was necessary for long-lasting PPI recovery and discovered a bilateral infusion of dominant-negative Delta JunD prevented PPI recovery after repeated D₂-like agonist treatment. To further develop the underlying mechanism of PPI recovery, we observed that dominant negative mutant cyclic adenosine monophosphate (cAMP) response biding element protein (CREB) prevented repeated D₂-like agonist-induced Delta FosB expression in the NAc. We then compared our previous behavioral and intracellular findings to the results of repeated aripiprazole, a novel D₂-like partial agonist antipsychotic, to determine if repeated D₂-like receptor agonist action is a clinically relevant pharmacological approach. As compared to previous PPI recovery and Delta FosB expression after repeated D₂-like agonist treatment, we found similar PPI recovery and Delta FosB expression after repeated aripiprazole treatment in rats. We can conclude that repeated D₂-like agonist treatment produces persistent PPI recovery through CREB phosphorylation and Delta FosB, which is necessary for PPI recovery. Furthermore, this pharmacological approach produces behavioral and intracellular changes similar to an effective novel antipsychotic. These findings suggest the underlying intracellular mechanism for sustained PPI recovery is clinically relevant and may be a potential target of therapeutic intervention to alleviate sensorimotor gating deficits, which are associated with cognitive symptoms of schizophrenia11ocn044276540file19991.00Maple, AmandaDigital Music Library : A Course Related Music Service of the Penn State University Libraries and Library Computing ServicesThis service provides Penn State students and instructors access to music being studied in courses at Penn State University. For each selection of music, you have the option of listening via the campus ethernet network at 112K or via dial-up modem at 28K (for use off campus)+-+1013835635+-+1013835635Thu Oct 16 15:25:20 EDT 2014batch6594