WorldCat Identities

Wieschaus, Eric F.

Works: 12 works in 17 publications in 3 languages and 85 library holdings
Genres: History  Biography  Documentary films 
Roles: Author
Classifications: QL470.D7, 576.509
Publication Timeline
Most widely held works by Eric F Wieschaus
SuperFly : a history of genetics( Visual )

3 editions published between 2002 and 2009 in English and held by 69 WorldCat member libraries worldwide

With two thirds of the same DNA as our own and a two-week breeding cycle, Drosophila melanogaster, or the fruit fly, is an ideal lab specimen. Using specialized photography, 3-D animation, and graphics, this program tells the story of the fruit fly's role in the history of genetics. Dramatizations recap Thomas Morgan's groundbreaking experiments at Columbia University. Nobel laureate Professor Eric Wieschaus of Princeton University, Professor Tim Tully of Cold Spring Harbor Laboratory and Professor Mike Levine of the University of California, Berkeley, and other scientists discuss ongoing research
Clonal analysis of early development in Drosophila melanogaster by Eric F Wieschaus( Book )

3 editions published between 1974 and 1975 in English and held by 3 WorldCat member libraries worldwide

Understanding reproductive aging regulation and mechanisms using a Caenorhabditis elegans model by Shijing Luo( Book )

1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide

To find the mechanisms of how the two pathways regulate oocyte quality, we performed microarrays comparing wild-type with TGF-beta Sma/Mab or IIS mutant oocytes, and comparing young with old wild-type oocytes. We found that several molecular functions are critical for C. elegans oocyte quality maintenance, such as chromosome segregation, cell cycle, and DNA damage response. These transcriptional analyses revealed that the TGF-beta Sma/Mab regulation of reproductive aging is separable from its control of body size, and that IIS regulates reproductive and somatic aging through distinct mechanisms. Additionally, the gene effectors associated with oocyte quality are conserved between C. elegans and humans, suggesting that the molecular mechanisms underlying their oocyte quality control are similar. Therefore our study may also provide insights into understanding the fundamental mechanisms of oocyte quality maintenance in humans
Quantitative Analysis of Signaling Pathways: Imaging and Modeling of the Terminal Patterning System of the Drosophila Embryo by Yoosik Kim( Book )

1 edition published in 2011 in English and held by 2 WorldCat member libraries worldwide

The experimental work in my dissertation demonstrates that this is indeed the case. Using the early Drosophila embryo as an experimental system, I have shown that the level of MAPK substrates can influence the activation status of this enzyme and its ability to distribute its activity among multiple substrates. In the first part of my thesis, I used a combination of genetic and imaging approaches to show that the spatial pattern of MAPK activation in the early embryo exhibits a striking asymmetry (Chapter 2 and Chapter 3). My subsequent genetic experiments revealed that this asymmetry is due to the spatially non-uniform distribution of the MAPK substrates that compete both among themselves and with the regulators of MAPK for access to this enzyme (Chapter 3 and Chapter 4). I have developed a chemical kinetics theory of the observed substrate competition effect and successfully tested this theory in vivo, using a large number of mutants in the MAPK pathway (Chapter 4). Finally, I was able to demonstrate that MAPK substrate competition is biologically significant and play a key role in the regulation of gene expression and cell differentiation in the embryo (Chapter 5 and Chapter 6). Going beyond the early Drosophila embryo, I propose that enzyme substrate competition is an important regulatory strategy in biomolecular networks where enzymes, such as MAPK, interact with their multiple regulators and substrates
Patterns of development( Visual )

2 editions published in 1987 in Catalan and English and held by 2 WorldCat member libraries worldwide

Studies the patterns of gene action during the earliest stages of development
From long-term gradients to local cell shape changes : how the Drosophila embryo controls its morphogenesis( Visual )

1 edition published in 2003 in English and held by 1 WorldCat member library worldwide

(Producer) Reviews what is known about gradients and cell determinants in Drosophila and focuses on current studies that investigate the cell biological mechanisms that use those gradients to the subsequent changes in cell morphology
Zygotic transcription and the control of embryonic development in Drosophila by Eric F Wieschaus( Visual )

1 edition published in 1997 in English and held by 1 WorldCat member library worldwide

Eric Wieschaus : [biographical note] by Eric F Wieschaus( )

1 edition published in 1996 in English and held by 1 WorldCat member library worldwide

From molecular patterns to morphogenesis : the lessons from Drosophila : Nobel lecture, December 8, 1995 by Eric F Wieschaus( )

1 edition published in 1996 in English and held by 1 WorldCat member library worldwide

Patrones de desarrollo( Visual )

1 edition published in 1987 in Spanish and held by 1 WorldCat member library worldwide

Los científicos han identificado un pequeño número de genes estudiando la mutación genética en la mosca de la fruta. Estudio de la expresión genética de estos genes mediante la hibridación in vitro, técnica que pone de manifiesto en qué segmento de un embrión es activo un gen
Audience Level
Audience Level
  Kids General Special  
Audience level: 0.31 (from 0.20 for SuperFly : ... to 0.99 for Wieschaus, ...)

Alternative Names
Eric F. Wieschaus ahli biologi asal Amerika Serikat

Eric F. Wieschaus Amerikaans bioloog

Eric F. Wieschaus amerikai genetikus, embriológus

Eric F. Wieschaus US-amerikanischer Biochemiker und Nobelpreisträger für Medizin

Eric Francis Wieschaus

Eric Frank Wieschaus

Eric Wieschaus biologo statunitense

Wieschaus, Eric Frank 1947-

Ерік Вішаус

Эрик Вишаус

Эрык Вішаўс

אריק פ. וישהאוס

إريك فيشاوس

ارک ایف. وسچاوس

اریک فرانسیس ویشوس زیست‌شناس آمریکایی

ایرک ویچاس

এরিক এফ উইস্কাস

에릭 F. 위샤우스