WorldCat Identities

Esteller, Manel

Overview
Works: 13 works in 52 publications in 4 languages and 1,273 library holdings
Genres: Handbooks and manuals  Documentary films 
Roles: Author, Editor, Interviewee
Publication Timeline
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Most widely held works by Manel Esteller
DNA methylation, epigenetics, and metastasis by Manel Esteller( )

15 editions published in 2005 in English and held by 705 WorldCat member libraries worldwide

"This book provides a broad and rich outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. It describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour. It also provides a comprehensive insightful look at the molecular players involved in DNA methylation, histone modification and chromatin remodelling complexes causing epigenetic lesions linked to the metastasic phenotypes."--Jacket
Epigenetics in biology and medicine by Manel Esteller( Book )

14 editions published between 2008 and 2009 in English and held by 279 WorldCat member libraries worldwide

"Anomalous epigenetic patterns touch many areas of study including biomedical, scientific, and industrial. With perspectives from international experts, this resource offers an all-inclusive overview of epigenetics, which bridge DNA information and function by regulating gene expression without modifying the DNA sequence itself."--Jacket
DNA methylation : approaches, methods, and applications by Manel Esteller( Book )

12 editions published between 2004 and 2005 in English and held by 273 WorldCat member libraries worldwide

"The book is a state-of-the-art reference for understanding the role DNA methylation plays in human disease, particularly cancer. Written by leaders in the field, this compilation of articles outlines the best techniques to address questions concerning the cytosine methylation status of genomic DNA. It includes concepts, experimental models, and clinical uses of demethylating agents. The book also provides a balance between articles clarifying methodological details and general review chapters that offer broad biological perspectives on DNA methylation." "Covering fundamental theory, technologies, and applications, DNA Methylation: Approaches, Methods, and Applications presents the most current research on using DNA methylation to decipher the pathways involved in human disease. This is an invaluable handbook for researchers and clinicians interested in genetics and molecular biology, particularly epigenetic therapies and gene silencing."--Jacket
DNA Methylation, Epigenetics and Metastasis by Manel Esteller( )

1 edition published in 2005 in English and held by 5 WorldCat member libraries worldwide

DNA Methylation, Epigenetics and Metastasis by Manel Esteller( )

1 edition published in 2005 in Undetermined and held by 2 WorldCat member libraries worldwide

Epigenetyka nowotworu by Manel Esteller( )

1 edition published in 2008 in Polish and held by 1 WorldCat member library worldwide

Què hi ha més enllà del genoma? : epigenètica en la salut i la malatia : acte acadèmic 2016, Monestir de Montserrat by Manel Esteller( Book )

1 edition published in 2017 in Catalan and held by 1 WorldCat member library worldwide

Obesity and menopause modify the epigenomic profile of breast cancer( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Abstract : Obesity is a high risk factor for breast cancer. This relationship could be marked by a specific methylome. The current work was aimed to explore the impact of obesity and menopausal status on variation in breast cancer methylomes. Data from Infinium 450K array-based methylomes of 64 breast tumors were coupled with information on BMI and menopausal status. Additionally, DNA methylation results were validated in 18 non-tumor and 81 tumor breast samples. Breast tumors arising in either pre- or postmenopausal women stratified by BMI or menopausal status alone were not associated with a specific DNA methylation pattern. Intriguingly, the DNA methylation pattern identified in association with the high-risk group (postmenopausal women with high BMI (>25) and premenopausal women with normal or low BMI < 25) exclusively characterized by hypermethylation of 1287 CpG sites as compared with the low-risk group. These CpG sites included the promoter region of fourteen protein-coding genes of which CpG methylation over the ZNF577 promoter region represents the top scoring associated event. In an independent cohort, the ZNF577 promoter methylation remained statistically significant in association with the high-risk group. Additionally, the impact of ZNF577 promoter methylation on mRNA expression levels was demonstrated in breast cancer cell lines after treatment with a demethylating agent (5-azacytidine). In conclusion, the epigenome of breast tumors is affected by a complex interaction between BMI and menopausal status. The ZNF577 methylation quantification is clearly relevant for the development of novel biomarkers of precision therapy in breast cancer
Aposta per la salut! : pensant en el futur, raons per ser optimista by Manel Esteller( Book )

1 edition published in 2014 in Catalan and held by 1 WorldCat member library worldwide

L'endemà( Visual )

1 edition published in 2014 in Catalan and held by 1 WorldCat member library worldwide

Documental que pretende responder con rigor a la pregunta sobre cómo se viviría en una Cataluña independiente y cómo debería ser ese nuevo país mediante entrevistas con más de cuarenta expertos que analizan algunos de los principales interrogantes que plantea el proceso soberanista. A la vez proyecta un hilo argumental dramatizado que transcurre paralelo a dichas intervenciones y que protagonizan cuatro jóvenes actores
VAV3 mediates resistance to breast cancer endocrine therapy by Helena Aguilar( )

1 edition published in 2014 in English and held by 1 WorldCat member library worldwide

INTRODUCTION: Endocrine therapies targeting cell proliferation and survival mediated by estrogen receptor alpha (ERalpha) are among the most effective systemic treatments for ERalpha-positive breast cancer. However, most tumors initially responsive to these therapies acquire resistance through mechanisms that involve ERalpha transcriptional regulatory plasticity. Here, we identify VAV3 as a critical component in this process. METHODS: A cell-based chemical compound screen was carried out to identify therapeutic strategies against resistance to endocrine therapy. Binding to ERalpha was evaluated by molecular docking analyses, an agonist fluoligand assay, and short-hairpin (sh) RNA-mediated protein depletion. Microarray analyses were performed to identify altered gene expression. Western blot of signaling and proliferation markers and shRNA-mediated protein depletion in viability and clonogenic assays were performed to delineate the role of VAV3. Genetic variation in VAV3 was assessed for association with the response to tamoxifen. Immunohistochemical analyses of VAV3 were carried out to determine the association with therapy response and different tumor markers. An analysis of gene expression association with drug sensitivity was carried out to identify a potential therapeutic approach based on differential VAV3 expression. RESULTS: The compound YC-1 was found to comparatively reduce the viability of cell models of acquired resistance. This effect was probably not due to activation of its canonical target (soluble guanylyl cyclase) but instead a result of binding to ERalpha. VAV3 was selectively reduced upon exposure to YC-1 or ERalpha depletion and, accordingly, VAV3 depletion comparatively reduced the viability of cell models of acquired resistance. In the clinical scenario, germline variation in VAV3 was associated with response to tamoxifen in Japanese breast cancer patients (rs10494071 combined P value = 8.4 x 10-4). The allele association combined with gene expression analyses indicated that low VAV3 expression predicts better clinical outcome. Conversely, high nuclear VAV3 expression in tumor cells was associated with poorer endocrine therapy response. Based on VAV3 expression levels and the response to erlotinib in cancer cell lines, targeting EGFR signaling may be a promising therapeutic strategy. CONCLUSIONS: This study proposes VAV3 as a biomarker and rationale signaling target to prevent and/or overcome resistance to endocrine therapy in breast cancer
Epigenética e hipermetilación( Book )

1 edition published in 2011 in Spanish and held by 1 WorldCat member library worldwide

 
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DNA methylation, epigenetics, and metastasis DNA Methylation, Epigenetics and Metastasis
Covers
Epigenetics in biology and medicineDNA methylation : approaches, methods, and applicationsDNA Methylation, Epigenetics and Metastasis
Alternative Names
Esteller Badosa, Manel 1968-

Esteller Badosa, Manuel 1968-

Esteller i Badosa, Manel 1968-

Manel Esteller

Manel Esteller Catalan geneticist and medical doctor

Manel Esteller científico español

Manel Esteller genetista i metge català

Manel Esteller Spaans klinische genetica

Languages