WorldCat Identities

Prescott, Stephen

Overview
Works: 3 works in 3 publications in 1 language and 13 library holdings
Classifications: N5220.M67,
Publication Timeline
Key
Publications about  Stephen Prescott Publications about Stephen Prescott
Publications by  Stephen Prescott Publications by Stephen Prescott
Most widely held works by Stephen Prescott
Here I stand : essays in honor of Dr. Paige Patterson ( Book )
1 edition published in 2000 in English and held by 6 WorldCat member libraries worldwide
The Dali adventure by Salvador Dali Museum ( Visual )
1 edition published in 1991 in English and held by 6 WorldCat member libraries worldwide
This is "an intimate portrayal of the recollections of A. Reynolds and Eleanor Morse about the genius, Salvador Dali."
The Role of Prostaglandins in the Growth of Breast Epithelial Cells ( Book )
1 edition published in 1998 in English and held by 1 WorldCat member library worldwide
Dietary fatty acids have been implicated as risk factors in breast carcinogenesis and our work, as well as that of others, has shown that they are regulators of the growth of breast epithelial cells. This project studied how linoleic acid and its metabolites stimulate the growth of breast epithelial cells. We found that this fatty acid causes induction of cyclooxygenase-2 by increasing transcription, and that this, in turn, generates products that stimulate growth. Linoleic acid and the products exert these action by binding to a target receptor, PPAR, which serves as a transcription factor that binds to an element in the promoter of the COX-2 gene, a mechanism identified for the first time in this project. We also discovered that the level of expression of COX-2 is controlled by the efficiency of translation of the mRNA and have shown that several proteins specifically mediate the effect. In summary, this project has determined the mechanism by which fatty acids stimulate the proliferation of breast cells, a process that offers the potential for intervention either by dietary manipulation or by chemoprevention using inhibitors of COX-2
 
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.32 (from 0.23 for The Dali a ... to 1.00 for The Role o ...)
Languages
English (3)