WorldCat Identities

Belkaid, Yasmine

Overview
Works: 14 works in 17 publications in 1 language and 23 library holdings
Genres: Academic theses 
Roles: Author
Publication Timeline
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Most widely held works by Yasmine Belkaid
Mucosal immunity( Book )

2 editions published in 2014 in English and held by 6 WorldCat member libraries worldwide

Trypanosome lytic factor, as a component of innate immunity. Analysis of its anti-leishmanial effect by Marie Samanovic-Golden( )

1 edition published in 2009 in English and held by 5 WorldCat member libraries worldwide

We first showed that TLF accumulates within the phagolysosome of macrophages in vitro and reduces the number of parasites at an early stage of the infection, without activating the macrophages. We found that TLF forms pores directly in the plasma membrane of the parasite, when in acidic conditions that mimic the pH of the phagolysosome. Lastly, to investigate the physiological relevance of this observation we reconstituted lytic activity in vivo by generating mice that express the two main protein components of TLFs: human apolipoprotein L-I and haptoglobin-related protein. Both proteins were expressed in mice at levels equivalent to those found in humans and circulate within high-density lipoproteins. We found that TLF mice can ameliorate an infection with Leishmania by significantly reducing the pathogen burden
The development and maintenance of B cell responses to microbial challenge by Arielle Glatman Zaretsky( Book )

2 editions published in 2014 in English and held by 2 WorldCat member libraries worldwide

Humoral responses are a critical component of the immune system and antibodies play an important role in the response to many pathogens. The work presented in this thesis examines the development, maintenance, and regulation of antibody production. T follicular helper (TFH) cells have been shown to provide B cell help in germinal centers (GCs). However, infection with T. gondii results in a loss of splenic organization, including the GCs. Thus, studies were performed to evaluate this splenic disorganization and the effects of this process on antibody responses. Furthermore, experiments to better understand the development of TFH cells revealed that TFH cells can arise from CD4 + T cells that have committed to the Th2 lineage in response to SEA immunization. However, aberrant B cell response can lead to antibody-mediated autoimmune disease, thus studies were conducted to further elucidate regulatory mechanisms to control GC responses. These revealed that IL-27 can inhibit GC responses through effects on TFH cells and directly through B cells. Finally, antibody responses are maintained long term through long-lived plasma cells in the bone marrow. Analysis of the Treg population in the bone marrow demonstrates a role for these cells in maintaining plasma cells, a relationship that can be transiently disrupted as both populations are lost during infection. Collectively, these studies highlight developmental processes and regulatory mechanisms that support B cell responses
Defining interactions between lymphoid tissue-resident commensal bacteria and the host immune system by Thomas Chia Ting Fung( Book )

2 editions published in 2016 in English and held by 2 WorldCat member libraries worldwide

The mammalian gastro-intestinal tract is colonized by trillions of beneficial commensal bacteria that are essential for promoting normal host physiology. While the majority of commensal bacteria are found in the intestinal lumen, many species have also adapted to colonize different anatomical locations in the intestine including the surface of intestinal epithelial cells (IECs) and the interior of gut-associated lymphoid tissues. Distinct tissue localization of commensal bacteria permits unique interactions between these microbes and the mammalian immune system and collectively influences intestinal immune cell homeostasis. Conversely, dysregulated localization of commensal bacteria can lead to inappropriate activation of the immune system and is associated with numerous chronic infectious, inflammatory and metabolic diseases. Therefore, regulatory mechanisms that control proper anatomical containment of commensal bacteria are essential to maintain tissue homeostasis and limit pathology. Although the roles of luminal and epithelial-associated commensal bacteria on immune cell homeostasis have been extensively studied, how lymphoid tissue-resident commensals (LRC) modulate host immune responses is not well understood. Data in Chapter 2 will describe interactions between a genetically related family of LRCs that can colonize dendritic cells and induces lymphoid tissue-specific immune responses. Further, Chapter 3 will provide evidence that LRC-induced immune responses are mutually beneficial for itself and the host. Specifically, LRC-induced interleukin (IL)-22 enhances its own microbial colonization and LRC-induced IL-10 limits tissue inflammation during intestinal injury
Demystifying medicine 2016( Visual )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

(CIT): Demystifying Medicine is an annual course from January to May designed to help bridge the gap between advances in biology and their application to major human diseases. The course includes presentation of patients, pathology, diagnosis, and therapy in the context of major disease problems and current research, primarily directed toward Ph.D. students, fellows, and staff. All are invited.For more information go to <a href='https://demystifyingmedicine.od.nih.gov/'>https://demystifyingmedicine.od.nih.gov/
Demystifying medicine. role in nutrition, metabolism, and inflamation by Yasmine Belkaid( Visual )

1 edition published in 2014 in English and held by 1 WorldCat member library worldwide

The primary shield : role of our microbes in heath and diseases( Visual )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

(CIT): NIH Director's Wednesday Afternoon Lecture Series The microbiota plays a fundamental role in the induction, education and function of the host immune system. In return, the host immune system has evolved multiple means by which to maintain its symbiotic relationship with the microbiota. The maintenance of this dialogue allows the induction of protective responses to pathogens and the utilization of regulatory pathways involved in the sustained tolerance to innocuous antigens. The ability of microbes to set the immunological tone of tissues, both locally and systemically, requires tonic sensing of microbes and complex feedback loops between innate and adaptive components of the immune system. Dr. Belkaid will discuss some of the dominant mediators of these interactions and discuss emerging themes associated with our current understanding of the immunological dialogue between the host and its microbiota in health and diseases. Dr. Belkaid work explores the field of immune regulation and has defined fundamental mechanisms that regulate tissue homeostasis and host immune responses. Her work uncovered key roles for the commensal microbiota and dietary factors in the maintenance of tissue immunity and protection to pathogens
Aberrant host defense against Leishmania major in the absence of SLPI( )

1 edition published in 2014 in English and held by 1 WorldCat member library worldwide

Control of Treg induction and function by microbes by Yasmine Belkaid( Visual )

1 edition published in 2010 in English and held by 1 WorldCat member library worldwide

(CIT): The Mucosal Immunology Unit's current work proposes that targeting host regulatory mechanisms will both uncover and unleash potent effector functions against parasites. To address these issues, they are focusing their research on one dermal parasite (Leishmania major) and three gastrointestinal pathogens, Cryptosporidium, and Microsporidium and Toxoplasma spp. Using these pathogens they are exploring the role, origin mechanism of action, and antigen presenting cell requirement of Treg that accumulate at sites of infection
Forging durable host-microbe interactions : role of foxp3 positive treg by Yasmine Belkaid( Visual )

1 edition published in 2008 in English and held by 1 WorldCat member library worldwide

Functional education of monocytes during infection by Michael Horne Askenase( Book )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Tissue-infiltrating Ly6Chi monocytes play important protective roles during infection, including inflammatory cytokine secretion and pathogen killing. Here we show that during acute gastrointestinal infection with the protozoan parasite Toxoplasma gondii, recruited monocytes not only contributed to parasite control, but also regulated pathologic immune responses to commensal microbes via secretion of the lipid mediator prostaglandin E2 (PGE2). Priming of monocytes for regulatory function preceded systemic inflammation and was initiated prior to bone marrow egress. Natural killer (NK) cell-derived IFN-? promoted a regulatory program in monocyte progenitors during development. Early bone marrow NK cell activation was controlled by systemic IL-12 produced by Batf3-dependent dendritic cells (DC) in the mucosal-associated lymphoid tissue (MALT). This work challenges the paradigm that monocyte function is dominantly imposed by local signals following tissue recruitment, and instead proposes a sequential model of differentiation in which monocytes are pre-emptively educated during development in the bone marrow to promote their tissue-specific function
Role of regulatory T cells in chronic infection by Yasmine Belkaid( Visual )

1 edition published in 2002 in English and held by 1 WorldCat member library worldwide

Protection against cutaneous leishmaniasis resulting from bites of uninfected sand flies by Shaden Kamhawi( )

1 edition published in 2000 in English and held by 0 WorldCat member libraries worldwide

CD4+CD25+ regulatory T cells control leishmania major persistence and immunity by Yasmine Belkaid( )

1 edition published in 2002 in English and held by 0 WorldCat member libraries worldwide

 
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Audience level: 0.81 (from 0.72 for The develo ... to 1.00 for Protection ...)

Alternative Names
Yasmine Belkaid algerisch-amerikanische Immunologin

Yasmine Belkaid American immunologist

Languages
English (17)