WorldCat Identities

Sakaguchi, Shimon

Works: 14 works in 29 publications in 3 languages and 255 library holdings
Roles: Editor, Author, Creator
Publication Timeline
Most widely held works by Shimon Sakaguchi
Regulatory T cells by Alexander Rudensky( )

15 editions published between 2006 and 2014 in English and held by 241 WorldCat member libraries worldwide

Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future. This volume focuses on regulatory T-cells. * Contributions from leading authorities and industry experts * Informs and updates on all the latest developments in the field
Gan to men'eki : gan men'eki ryōhō no mekanizumu kaimei to rinshō eno tenkai( Book )

2 editions published in 2015 in Japanese and held by 2 WorldCat member libraries worldwide

Naturally arising CD4+ regulatory T cells in immunologic self-tolerance and immune regulation by Shimon Sakaguchi( Visual )

1 edition published in 2003 in English and held by 1 WorldCat member library worldwide

(CIT): The Immunology Interest Group (IIG) organizes activities designed to promote information exchange and interactions among NIH scientists interested in the field of immunology, broadly defined. Interactions are facilitated via weekly meetings on current topics as well as an annual Immunology Retreat. For more information, visit The Immunology Interest Group
Immunological reviews. Regulatory T cells( Book )

1 edition published in 2006 in English and held by 1 WorldCat member library worldwide

Regulatory T cells and immune tolerance( )

in English and held by 1 WorldCat member library worldwide

Seigyosei tī saibō men eki ōtō o fu ni seigyo suru( Book )

1 edition published in 2002 in Japanese and held by 1 WorldCat member library worldwide

Tokushū men'eki ōtō no fu no seigyo men'eki kōjōsei no iji to shikkan chiryō eno ōyō( Book )

1 edition published in 2013 in Japanese and held by 1 WorldCat member library worldwide

Autoimmunity( Book )

1 edition published in 2005 in English and held by 1 WorldCat member library worldwide

Molecular control of regulatory T cell development and function( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Highlights: Foxp3 + Treg cells possess distinct transcriptional and epigenetic landscapes. Treg cell development is guided by gradual setup of an enhancer landscape. Foxp3 expression and DNA hypomethylation stabilizes Treg cells in the periphery. Defects in various stages of Treg cell life are associated with autoimmunity. Abstract : Treg cells expressing the transcription factor Foxp3 are essential for immunological tolerance and homeostasis. Recent genome-wide studies have revealed that Foxp3 + natural Treg cells possess a number of unique transcriptional and epigenetic features, which appear to be acquired along the course of Treg cell development and maintained throughout their lifespan. These studies also provide novel insights into how genomic variations contribute to genetic susceptibility to human autoimmune diseases by affecting Treg cell development and function
Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Abstract : Objective: The intestinal microbiota is involved in the pathogenesis of arthritis. Altered microbiota composition has been demonstrated in patients with rheumatoid arthritis (RA). However, it remains unclear how dysbiosis contributes to the development of arthritis. The aim of this study was to investigate whether altered composition of human intestinal microbiota in RA patients contributes to the development of arthritis. Methods: We analyzed the fecal microbiota of patients with early RA and healthy controls, using 16S ribosomal RNA−based deep sequencing. We inoculated fecal samples from RA patients and healthy controls into germ‐free arthritis‐prone SKG mice and evaluated the immune responses. We also analyzed whether the lymphocytes of SKG mice harboring microbiota from RA patients react with the arthritis‐related autoantigen 60S ribosomal protein L23a (RPL23A). Results: A subpopulation of patients with early RA harbored intestinal microbiota dominated by Prevotella copri ; SKG mice harboring microbiota from RA patients had an increased number of intestinal Th17 cells and developed severe arthritis when treated with zymosan. Lymphocytes in regional lymph nodes and the colon, but not the spleen, of these mice showed enhanced interleukin‐17 (IL‐17) responses to RPL23A. Naive SKG mouse T cells cocultured with P copri −stimulated dendritic cells produced IL‐17 in response to RPL23A and rapidly induced arthritis. Conclusion: We demonstrated that dysbiosis increases sensitivity to arthritis via activation of autoreactive T cells in the intestine. Autoreactive SKG mouse T cells are activated by dysbiotic microbiota in the intestine, causing joint inflammation. Dysbiosis is an environmental factor that triggers arthritis development in genetically susceptible mice
Minimum Information about T Regulatory Cells a Step toward Reproducibility and Standardization by Anke Fuchs( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety of autoimmune and allergic diseases as well as posttransplant complications. Nevertheless, current manufacturing of Tregs as a cellular medicinal product varies between different laboratories, which in turn hampers precise comparisons of the results between the studies performed. While the number of clinical trials testing Tregs is already substantial, it seems to be crucial to provide some standardized characteristics of Treg products in order to minimize the problem. We have previously developed reporting guidelines called minimum information about tolerogenic antigen-presenting cells, which allows the comparison between different preparations of tolerance-inducing antigen-presenting cells. Having this experience, here we describe another minimum information about Tregs (MITREG). It is important to note that MITREG does not dictate how investigators should generate or characterize Tregs, but it does require investigators to report their Treg data in a consistent and transparent manner. We hope this will, therefore, be a useful tool facilitating standardized reporting on the manufacturing of Tregs, either for research purposes or for clinical application. This way MITREG might also be an important step toward more standardized and reproducible testing of the Tregs preparations in clinical applications
Siły pokojowe układu odpornościowego by Zoltán Fehérvári( )

1 edition published in 2006 in Polish and held by 1 WorldCat member library worldwide

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Audience level: 0.61 (from 0.54 for Autoimmuni ... to 0.99 for Siły pokoj ...)

Regulatory T cells
Alternative Names
Sakaguchi, Shimon

Shimon Sakaguchi

Shimon Sakaguchi Japanese physician, university teacher and immunologist

Shimon Sakaguchi Japans arts

Сакагути, Симон

サカグチ, シモン