WorldCat Identities

Cuervo, Ana Maria

Overview
Works: 18 works in 19 publications in 2 languages and 62 library holdings
Genres: Academic theses 
Roles: Author, Speaker
Publication Timeline
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Most widely held works by Ana Maria Cuervo
Protein homeostasis during aging by Ana Maria Cuervo( Visual )

1 edition published in 2016 in English and held by 39 WorldCat member libraries worldwide

Chaperone-mediated autophagy and cancer by Maria Kon( )

1 edition published in 2011 in English and held by 2 WorldCat member libraries worldwide

Chemical modulation of chaperone-mediated autophagy by novel retinoic acid derivatives by Jaime Anguiano( )

1 edition published in 2013 in English and held by 2 WorldCat member libraries worldwide

The physiological effects of stress and aging on chaperone-mediated autophagy by Roberta Kiffin( )

1 edition published in 2010 in English and held by 2 WorldCat member libraries worldwide

Restoration of chaperone-mediated autophagy in aging mice by Cong Zhang( Book )

1 edition published in 2008 in English and held by 2 WorldCat member libraries worldwide

Pathophysiological relevance of chaperone-mediated autophagy by Ashish C Massey( Book )

1 edition published in 2007 in English and held by 2 WorldCat member libraries worldwide

Lisosomas : algo mas que vertederos celulares by Ana Maria Cuervo( )

2 editions published in 1997 in Spanish and held by 2 WorldCat member libraries worldwide

Regulation of chaperone-mediated autophagy by Susmita Kaushik( Book )

1 edition published in 2009 in English and held by 2 WorldCat member libraries worldwide

Did you remember to take out the trash? : your cells sure did! by Ana Maria Cuervo( Visual )

1 edition published in 2014 in English and held by 1 WorldCat member library worldwide

(CIT): Wednesday Afternoon Lecture Series The Annual Margaret Pittman Lecture The lecture honors Dr. Margaret Pittman, NIH"s first female lab chief, who made significant contributions to microbiology and vaccine development, particularly in the areas of pertussis and tetanus, during her long career at NIAID. Dr. Ana Maria Cuervo, Professor and Co-director of the Institute of Aging Research, Albert Einstein College of Medicine, will deliver the Wednesday Afternoon Lecture Series (WALS) annual Margaret Pittman Lecture on March 19. Dr. Cuervo is a leader in the field of protein degradation in relation to the biology of aging, and currently studies the role of protein-degradation in aging and age-related disorders, with an emphasis on neurodegeneration. Autophagy is an essential catabolic cellular process that assures the maintenance of the cellular energetic balance as wells as an efficient removal of any intracellular damaged structure. In this talk, Dr. Cuervo will focus on selective forms of autophagy and describe her lab"s recent advances on the identification of new molecular effectors and regulators for these pathways, the physiological role, and their changes in aging and age-related metabolic disorders and neurodegenerative diseases such as Parkinson, Alzheimer and Huntington disease. She will also present some of her lab"s genetic and chemical efforts to modulate autophagy to enhance the cellular defense against stress
Protein homeostasis during aging by Ana Maria Cuervo( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Chaperone-mediated autophagy : tales from an old "picky" broom by Ana Maria Cuervo( Visual )

1 edition published in 2008 in English and held by 1 WorldCat member library worldwide

(CIT): Cells count on surveillance systems to handle protein alterations. Malfunctioning of these systems contribute in large extend to the abnormal accumulation of those altered proteins in cells and tissues in numerous diseases and in aging. Our studies have focused primarily in one of the cellular systems for protein removal, chaperone-mediated autophagy (CMA), which mediates selective targeting of cytosolic proteins to lysosomes for their degradation. CMA is active in most mammalian cell types but its activity varies depending on cellular conditions. Maximal activation of CMA is attained during stresses such as nutritional stress, mild-oxidative stress or toxin exposure. Degradation by CMA requires the presence of a targeting motif in the substrate protein, a set of cytosolic and lysosomal chaperones and a receptor protein at the lysosomal membrane. Blockage of CMA in culture cells diminishes their ability to adapt to most types of stresses and promotes formation of protein aggregates. Using this model, we have revealed a cross-talk among different removal systems, since in response to diminished CMA activity cells activate other forms of autophagy that compensate for CMA failure, but renders them susceptible to stress. CMA activity declines with age and in some age-related pathologies such as Parkinson"s disease. We have identified the reason for the decline in CMA function with age as a decrease in the levels of the lysosomal receptor that mediates substrate translocation. Our group is currently developing different approaches aimed to restore normal CMA activity in old rodents. These models would help us evaluate the importance of maintaining proper protein removal until advanced ages, and, on light of the observed cross-talk among autophagic pathways, the effect that repairing one autophagic pathway may have on the functioning of the others. The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. For more information, visit http://www.aecom.yu.edu/cuervo
Lipid kinase P14K111B preserves lysosomal identity by Sunandini Sridhar( Book )

1 edition published in 2012 in English and held by 1 WorldCat member library worldwide

Interplay between Parkinson's disease proteins and chaperone-mediated autophagy by Samantha J Orenstein Hutten( )

1 edition published in 2013 in English and held by 1 WorldCat member library worldwide

Characterization of the lysosomal translocation complex for chaperone-mediated autophagy by Urmi Bandyopadhyay( Book )

1 edition published in 2008 in English and held by 1 WorldCat member library worldwide

Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy by Sooyeon Lee( Book )

1 edition published in 2011 in English and held by 1 WorldCat member library worldwide

The robust accumulation of abnormally large number of autophagic vesicles (AVs) in grossly enlarged "dystrophic" neurites represent the most abundant neuropathology in the AD brain. The highly disproportionate accumulation of protein-laden AVs within dystrophic swellings implicates dysfunction in the autophagic pathway and particularly of lysosomal degradation. In this thesis, I explore the mechanism and functional implications of impaired autophagic/lysosomal degradation for autophagic vesicles accumulation. In primary cortical neurons, lysosomal cysteine protease inhibition by leupeptin treatment or lysosomal acidic protease inhibitor bafilomycin, but not rapamycin-induced activation, reduced the mobility of autophagosomes and late endosomal/lysosomal compartments, without impairments in mitochondria or early endosome transport. Proteolysis inhibition also resulted in the formation of dystrophic axon swellings containing selective endo-lysosome/AV cargoes that were similar to those previously described in AD brain. The selective transport defects of specific vesicular cargoes by lysosomal system dysfunction--as shown to be marked in AD--provides a possible basis for the selective accumulation of these same cargoes in dystrophic neurites in AD brain
Effect of blockage of chaperone-mediated autophacy in vivo by Jaime Laurel Schneider( Book )

1 edition published in 2014 in English and held by 1 WorldCat member library worldwide

The role of selective autophagy on TAU clearance by Benjamin Caballero Bendixsen( Book )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Impaired degradation of mutant, -synuclein by chaperone-mediated autophagy by Ana Maria Cuervo( )

1 edition published in 2004 in English and held by 0 WorldCat member libraries worldwide

 
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Audience level: 0.66 (from 0.52 for Protein ho ... to 1.00 for Impaired d ...)

Alternative Names
Ana María Cuervo bioquímica catalana

Ana María Cuervo bioquímica española

Ana María Cuervo Spaans wetenschapster

Ana María Cuervo Spanish scientist and biochemist

Languages