WorldCat Identities

Szostak, Jack W.

Overview
Works: 20 works in 32 publications in 3 languages and 228 library holdings
Genres: Educational films  Internet videos  History  Biography  Nonfiction films 
Roles: Editor, Author
Classifications: PN1997, 576.83
Publication Timeline
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Most widely held works about Jack W Szostak
 
Most widely held works by Jack W Szostak
The origins of life : a subject collection from Cold Spring Harbor perspectives in biology by David W Deamer( Book )

8 editions published in 2010 in English and held by 204 WorldCat member libraries worldwide

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive account of the environment of the early Earth and the mechanisms by which the organic molecules present may have self-assembled to form replicating material such as RNA and other polymers. The contributors examine the energetic requirements for this process and focus in particular on the essential role of semi-permeable compartments in containment of primitive genetic systems
Nobel Minds 2009( Visual )

2 editions published in 2010 in English and held by 5 WorldCat member libraries worldwide

Host introduces several topics for discussion including United States President, Barack Obama receiveing the Noble Peace Prize, global warming/integrity of science, and practical applications of their discoveries
Combinatorial chemistry( Book )

3 editions published in 1997 in English and held by 4 WorldCat member libraries worldwide

Specific binding of a synthetic oligonucleotide to the yeast iso-1 cytochrome c̲ mRNA and gene by Jack W Szostak( Book )

3 editions published in 1977 in English and held by 3 WorldCat member libraries worldwide

Life on earth : fresh clues hint at how the first living organisms arose from inanimate matter by Jack W Szostak( )

1 edition published in 2009 in English and held by 1 WorldCat member library worldwide

In vitro evolution of a self-alkylating ribozyme by Charles Wilson( Book )

1 edition published in 1995 in English and held by 1 WorldCat member library worldwide

Jak chemię zamienić na biologię by Jack W Szostak( )

1 edition published in 2009 in Polish and held by 1 WorldCat member library worldwide

Jak powstało życie na Ziemi by Alonso Ricardo( )

1 edition published in 2009 in Polish and held by 1 WorldCat member library worldwide

El origen de la vida by Alonso Ricardo( )

1 edition published in 2009 in Spanish and held by 1 WorldCat member library worldwide

Life on Earth by Alonso Ricardo( Book )

1 edition published in 2009 in Undetermined and held by 1 WorldCat member library worldwide

Fatty Acid/Phospholipid Blended Membranes: A Potential Intermediate State in Protocellular Evolution( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Abstract: Prior to the evolution of membrane proteins, intrinsic membrane stability and permeability to polar solutes are essential features of a primitive cell membrane. These features are difficult to achieve simultaneously in model protocells made of either pure fatty acid or phospholipid membranes, raising the intriguing question of how the transition from fatty acid to phospholipid membranes might have occurred while continuously supporting encapsulated reactions required for genomic replication. Here, the properties of a blended membrane system composed of both oleic acid (OA), a monoacyl fatty acid, and 1‐palmitoyl‐2‐oleoyl‐ sn ‐glycero‐3‐phosphocholine (POPC), a diacyl phospholipid are described. This hybrid vesicle system exhibits high stability to divalent cations (Mg 2+ ), while simultaneously maintaining its permeability to small charged molecules such as nucleotides and divalent ions such as Mg 2+ . This combination of features facilitates key reactions expected to occur during a transition from primitive to modern cells, including nonenzymatic RNA replication, and is also compatible with highly evolved functions such as the ribosomal translation of a protein. The observations support the hypothesis that the early transition from fatty acid to phospholipid membranes could be accomplished through intermediate states in which membranes are composed of amphiphile mixtures, and do not require protein transporters. Abstract : The initial transition from fatty acid membranes (gray) to phospholipid membranes (purple) in primitive cells may have been facilitated by the properties of membranes composed of both amphiphiles. Such hybrid membranes achieve high stability to divalent cations while maintaining permeability to small charged molecules, thus allowing critical chemical reactions to proceed within primitive cells
A DNA metalloenzyme with DNA ligase activity by Bernard Cuenoud( Book )

1 edition published in 1995 in English and held by 1 WorldCat member library worldwide

Learning about the origin of life from efforts to design an artificial cell by Jack W Szostak( Visual )

1 edition published in 2007 in English and held by 1 WorldCat member library worldwide

(CIT): The complexity of modern biological life has long made it difficult to understand how life could emerge spontaneously from the chemistry of the early earth. The key to resolving this mystery lies in the simplicity of the earliest living cells. Through our efforts to synthesize extremely simple artificial cells, we hope to discover plausible pathways for the transition from chemical evolution to Darwinian evolution. We view the two key components of a primitive cell as a self-replicating nucleic acid genome, and a self-replicating boundary structure. I will discuss recent experimental progress towards the synthesis of self-replicating nucleic acid and membrane vesicle systems, and the implications of these experiments for our understanding of the origin of life. Dr. Szostak is an Investigator of the Howard Hughes Medical Institute, Professor of Genetics at Harvard Medical School, and the Alex Rich Distinguished Investigator in the Dept. of Molecular Biology and the Center for Computational and Integrative Biology at Massachusetts General Hospital. His current research interests are in the laboratory synthesis of self-replicating systems, the origin of life, and applied evolutionary chemistry. He and his colleagues have developed in vitro selection as a tool for the isolation of rare functional RNA, DNA and protein molecules from large pools of random sequences. His laboratory has used in vitro selection and directed evolution to isolate and characterize numerous nucleic acid sequences with specific ligand binding and catalytic properties. For this work, Dr. Szostak was awarded, along with Dr. Gerald Joyce, the 1994 National Academy of Sciences Award in Molecular Biology and the 1997 Sigrist Prize from the University of Bern. Dr. Szostak is a member of the National Academy of Sciences, and a Fellow of the New York Academy of Sciences and the American Academy of Arts and Sciences. In 2000, Dr. Szostak was awarded the Medal of the Genetics Society of America, and in 2006 Dr. Szostak shared the Albert Lasker Basic Medical Research Award with Elizabeth Blackburn and Carol Greider. For more information, visit http://www.hhmi.org/research/investigators/szostak.html The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide
Functional proteins from a random-sequence library by Anthony D Keefe( )

1 edition published in 2001 in English and held by 0 WorldCat member libraries worldwide

In vitro evolution suggests multiple origins for the hammerhead ribozyme by Kourosh Salehi-Ashtiani( )

1 edition published in 2001 in English and held by 0 WorldCat member libraries worldwide

Artificial chromosomes by Andrew Wood Murray( Book )

1 edition published in 1987 in English and held by 0 WorldCat member libraries worldwide

RNA gets a grip on translation by Jack W Szostak( )

1 edition published in 2002 in English and held by 0 WorldCat member libraries worldwide

 
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The origins of life : a subject collection from Cold Spring Harbor perspectives in biology
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Alternative Names
Jack Szostak ahli biologi asal Polandia

Jack Szostak American biologist

Jack Szostak Amerikaans bioloog

Jack Szostak US-amerikanischer Molekularbiologe

Jack Szostak usona biologo

Jack W. Szostak

Jack W. Szostak biologo canadese

Jack William Szostak

Jack William Szostak kanadai-amerikai molekuláris biológus

Szostak, Jack W.

Джак Шостак

Джек Шостак

Джэк Шостак

Шостак, Джек

Ջեկ Շոստակ

ג'ק שוסטק

جاك زوستاك

جک ژوستاک

جیک زوستاک

جیک ڈبلیو. سزوسٹک

जैक शॉस्तक

জ্যাক সজটাক

ஜாக் சோஸ்டாக்

ജാക്ക്. ഡബ്ല്യൂ. ഷോസ്റ്റാക്ക്

잭 쇼스택

ジャック・W・ショスタク

杰克·绍斯塔克

傑克·索斯塔克

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