WorldCat Identities

Pollack, Alan 1946-

Overview
Works: 13 works in 48 publications in 3 languages and 849 library holdings
Genres: Fiction  Miscellanea  Documentary films 
Roles: Author
Classifications: QA613.6, 514.7
Publication Timeline
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Most widely held works by Alan Pollack
Differential topology by Victor Guillemin( Book )

28 editions published between 1974 and 2014 in English and Undetermined and held by 821 WorldCat member libraries worldwide

Topología diferencial by Victor Guillemin( Book )

3 editions published in 2003 in Spanish and held by 4 WorldCat member libraries worldwide

Hypofractionation : scientific concepts and clinical experiences( Book )

1 edition published in 2011 in English and held by 3 WorldCat member libraries worldwide

The Molecular Mechanism of the Supra-Additive Response of Prostate Cancer to Androgen Ablation and Radiotherapy( Book )

3 editions published between 1999 and 2001 in English and held by 2 WorldCat member libraries worldwide

The main objectives of the proposal are to measure the molecular changes induced by androgen ablation and radiotherapy, to relate these changes to the supra-additive apoptotic response of androgen ablation plus radiation, and to use these data to develop a gene therapy strategy. Prostate cancer is the most common cancer in men, yet our understanding of the interaction of androgen ablation and radiation at the molecular level is severely lacking. The proposed project will define the role of the key proteins in the apoptotic pathway, p53, bax, and bcl-2. Considerable progress has been made on two fronts: first, characterization of pretreatment biomarker levels in human prostate cancers and second, the development of a gene therapy strategy using adenoviral-p53 and adenoviral E2F. In the latter studies, these vectors have been found to sensitize both LNCaP and PC3 cells to radiation, and preliminary data with Ad5-p53 suggest an added benefit when androgen ablation is added. Some delays have been encountered in measurement of biomarker level changes in LNCaP cells cultured in androgen deprived medium. The problems with the system have been resolved and this analysis is now underway. The immediate significance of these studies is that two gene therapy strategies have been developed and a clinical trial written to test the feasibility, morbidity and efficacy of this approach. The significance of the androgen ablation mechanism/biomarker studies will be manifest at the end of next year
Bibun isō kikagaku( Book )

2 editions published in 1998 in Japanese and held by 2 WorldCat member libraries worldwide

Anachronism( Visual )

1 edition published in 2004 in English and held by 1 WorldCat member library worldwide

Anachronism playing card collection includes collecitable cards from combat games where great warriors are pitted against each other in one-on-one battle to the death. Cf. Noble Knight Games. Each card has a brief description of the warrior or item
Yaetzer hurrah! : thoughts of sin : bassoon solo by Alan Pollack( )

1 edition published in 1977 and held by 1 WorldCat member library worldwide

Visions from the edge : the art of science fiction( Visual )

1 edition published in 2005 in English and held by 1 WorldCat member library worldwide

Five science fiction artists discuss the process of their art
Prostate cancer management : trends in practice( Recording )

1 edition published in 2009 in English and held by 1 WorldCat member library worldwide

Trapped by James Alan Gardner( Book )

1 edition published in 2002 in English and held by 1 WorldCat member library worldwide

"Strange things are happening on a backwater world called Earth."--Cover
Sensitization of Prostate Cancer Cells to Androgen Deprivation and Radiation via Manipulation of the MDM2 Pathway( Book )

4 editions published between 2004 and 2006 in English and held by 1 WorldCat member library worldwide

Androgen deprivation (AD) is a common treatment for prostate cancer, yet the mechanisms of action are poorly understood. Radiotherapy (RT) is also often used in the treatment of localized disease and AD+RT in more high risk cases. Our results indicate that MDM2 is central to prostate cancer response to AD, RT, and AD+RT. Our data establish that by reducing the expression of MDM2 with an antisense oligonucleotide (AS-MDM2) the apoptotic response of LNCaP cells in vitro to AD, RT, and AD+RT is increased. The enhancements in apoptosis translated into gains in overall cell death (measured by clonogenic assay) . These interactions were reduced in LNCaP-MST cells that overexpressed MDM2. Preliminary findings in vivo indicate that AS-MDM2 sensitizes LNCaP cells to AD; the experiments are still in progress. We have also found that MDM2 overexpression was evident in 48% of a cohort of locally advanced men treated on Radiation Therapy Oncology Group protocol 86-10, correlated with Gleason score and was associated with a trend for increased distant metastasis. MDM2 is a promising target for enhancing prostate cancer response to AD, RT, and AD+RT, which could potentially impact men with virtually any stage of disease
Localized prostate cancer : maximizing outcomes( Recording )

1 edition published in 2005 in English and held by 0 WorldCat member libraries worldwide

 
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Audience level: 0.54 (from 0.29 for Trapped / ... to 1.00 for Localized ...)

Differential topology
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