WorldCat Identities

Shapiro, Charles L.

Works: 3 works in 15 publications in 1 language and 71 library holdings
Roles: Editor
Publication Timeline
Most widely held works by Charles L Shapiro
New directions in breast cancer : research and therapeutics( Book )

8 editions published in 1994 in English and held by 62 WorldCat member libraries worldwide

Late effects of treatment and survivorship issues in early-stage breast carcinoma( Book )

2 editions published in 2003 in English and held by 6 WorldCat member libraries worldwide

The Effect of COX-2 Inhibitors on the Aromatase Gene (CYP19) Expression in Human Breast Cancer( Book )

5 editions published between 2002 and 2006 in English and held by 2 WorldCat member libraries worldwide

Aromatase (CYP-l9) is responsible for estrogen biosynthesis within breast tumor tissue Aromatase and cyclooxygenase-2 (COX-2) are both overexpressed in human breast cancer, and increased levels of prostaglandin (PG) activates the CYPl9 promotor and increases gene expression We hypothesize that celecoxib, a selective COX-2 inhibitor, will decrease PG, decrease the expression of CYPl9, and reduce estrogen biosynthesis within tumor tissue To test this hypothesis, in DOD grant # DAMDl7-0l-0589, tumor tissue will be collected from breast cancer patients at the initial diagnosis, and again at the definitive surgery (lumpectomy or mastectomy) for breast cancer In the 10-14 day internal before the definitive surgery, patients will receive celecoxib and tissue samples collected before and after treatment with celecoxib will be evaluated for gene expression of COX-2 and CYP19 If our hypothesis is correct, then expression of the CYPl9 gene will decrease in response to celecoxib This study will provide preliminary data to a) support a mechanism whereby COX-2 inhibitors decrease estrogen production within breast tumors by decreasing CYPl9 expression; and b) provide the rationale for initiating larger chemoprevention and therapeutic trials of COX-2 inhibitors in high risk and breast cancer patients
Audience Level
Audience Level
  Kids General Special  
Audience level: 0.71 (from 0.69 for New direct ... to 0.96 for The Effect ...)

Associated Subjects
English (15)