WorldCat Identities

Ferreira, Sergio H.

Overview
Works: 18 works in 19 publications in 3 languages and 33 library holdings
Roles: Editor, Thesis advisor
Classifications: QP905, 615.108 S
Publication Timeline
Key
Publications about  Sergio H Ferreira Publications about Sergio H Ferreira
Publications by  Sergio H Ferreira Publications by Sergio H Ferreira
Most widely held works by Sergio H Ferreira
Anti-inflammatory drugs ( Book )
2 editions published in 1979 in German and English and held by 9 WorldCat member libraries worldwide
Inflammation ( Book )
1 edition published in 1978 in English and held by 7 WorldCat member libraries worldwide
Brazilian Journal of Medical and Biological Research 1981-2002 by Eduardo Moacyr Krieger ( )
1 edition published in 2003 in English and held by 2 WorldCat member libraries worldwide
Nitric oxide mediates the microbicidal activity of eosinophils by Sandra H. P Oliveira ( )
1 edition published in 1997 in English and held by 2 WorldCat member libraries worldwide
There are several experimental evidences that nitric oxide (NO) is involved in the microbicidal activity of macrophages against a number of intracellular pathogens including Leishmania major, Trypanosoma cruzi, Toxoplasma gondii. It is also well known that eosinophils (EO) have microbicidal activity against many parasites such as Schistosoma mansoni, Trichenella spiralis, T. cruzi and L. amazonensis. The purpose of this study was to investigate if NO is involved in the microbicidal activity of EO against L. major. Eosinophils harvested from peritoneal cavity of rats released spontaneously after 24 and 48 hr a small amount of nitrite. This release was enhanced by the treatment of cells with IFN-gamma (200 IU/ml). This release was blocked by addition of the NO synthase inhibitor, L-NIO (100-M) into the culture. To determine the leishmanicidal activity of eosinophils the parasites were incubated with activated eosinophils with IFN-gamma and the abiblity of surviving parasites to incorporate [3H] thymidine was evaluated. IFN-gamma-activated eosinophils were able to kill L. major and to release high levels of nitrite. The ability to destroy L. major and the release of NO were completely blocked by L-NIO. These results indicate that activated eosinophils release NO which is involved in the microbicidal activity of these cells against L. major. (AU)
Participation of interleukin-5, interleukin-8 and leukotriene B4 in eosinophil accumulation in two different experimental models by Sandra H. P Oliveira ( )
1 edition published in 1997 in English and held by 2 WorldCat member libraries worldwide
There are several experimental models descibing in vivo eosinophil (EO) migration, including injection of a large volume of saline (SAL) or Sephadex beads (SEP). The aim of this study was to investigate the mechanisms involved in the EO migration in these two models. Two consecutive injections of SAL given 48 hr apart, induced a selective recruitment of EO into peritoneal cavity of rats, which peaked 48 hr after the last injection. SEP, when injected, promoted EO accumulation in rats. The phenomenom was dose-related and peaked 48 hr after injection. To investigate the mediators involved in this process we showed that BW A4C, MK 886 and dexamethasone (DXA) inhibited the EO migration induced by SAL and SEP. To investigate the source of the EO chemotactic factor we showed that mast cells, macrophages (MO), but not lymphocytes, incubated in vitro in presence of SAL released a factor which induced EO migration. With SEP, only mast cells release a factor that induced EO migration, which was inhibited by BW A4C, MK 886 and DXA. Furthermore, the chemotactic activity of SAL-stimulated mast cells was inhibited by antisera against IL-5 and IL-8 (interleukin). SAL-stimulated MO were only inhibited by anti-IL-8 antibodies as well as SEP-stimulated mast cells. These results suggest that the EO migration induced by SAL may be dependent on resident mast cells and MO mediated by LTB4, IL-5 and IL-8. SEP-induced EO migration was dependent on mast cells and may be mediated by LTB4 and IL-8. Furthermore, IL-5 and IL-8 induced EO migration, which was also dependent on resident cells and mediated by LTB4. In conclusion, EO migration induced by SAL is dependent on mast cells and MO, whereas that induced by SEP is dependent on mast cells alone. Stimulated mast cells release LTB4, IL-5 and IL-8 while MO release LTB4 and IL-8. The IL-5 and and IL-8 release by the SAL or SEP-stimulated resident cells may act in an autocrine fashion, thus potentiating LTB4 release. (AU)
Características farmacológicas do fator hiperalgésico de macrófagos (FHM) e sua presença na resposta inflamatória aguda ( Book )
1 edition published in 1986 in Portuguese and held by 1 WorldCat member library worldwide
Estudo dos mediadores, perifericos da nocicepção inflamatoria em articulações estimuladas uma unica vez ou re-estimuladas by Carlos Rogerio Tonussi ( Book )
1 edition published in 1996 in Portuguese and held by 1 WorldCat member library worldwide
Fatores hiperalgésicos presentes no macrófago by Janetti Nogueira de Francischi ( Book )
1 edition published in 1982 in Portuguese and held by 1 WorldCat member library worldwide
Aspectos moleculares envolvidos na indução, desenvolvimento e bloqueio da hipernocicepção mecânica persistente by Daniela Sachs ( Book )
1 edition published in 2004 in Portuguese and held by 1 WorldCat member library worldwide
Demonstramos anteriormente que injeções intraplantares diárias, por 14 dias, de prostaglandina 'E IND. 2' ('PGE IND. 2') ou dopamina, induzem um processo hipernociceptivo que persiste por até 30 dias após a suspensão da administração dessas substâncias, fenômeno denominado hipernocicepção mecânica persistente (HMP). A HMP é inibida pela administração de dipirona ou N-metil morfina sendo restaurada por 'PGE IND. 2' ou dopamina, em baixas doses. No presente trabalho investigamos os mecanismos intracelulares envolvidos na indução, manutenção e bloqueio da HMP. Demonstramos que o processo de indução da HMP é mediado por AMPc visto que a administração, por 14 dias, de DbcAMP (análogo do AMPc) ou a co-administração de rolipram (inibidor de fosfodiesterase tipo 4) + 'PGE IND. 2' (baixa doses), assim como a administração em dose única de toxina da cólera (induz estimulação persistente de adenilato ciclase, AC) induziram HMP. Embora o AMPc esteja envolvido na indução da HMP este não participa da manutenção da HMP isto porque o SQ22536 (inibidor de AC) não alterou a HMP instalada. Por outro lado os tratamentos com inibidores de proteinoquinase A e C inibiram a HMP instalada. Portanto, concluímos que o AMPc participa da indução da HMP pela 'PGE IND. 2', no entanto, a manutenção da HMP não depende da persistente ativação da AC, mas é dependente da ativação de proteinoquinase A e C. Investigando a participação de canais de sódio ('Na P
Do fator potenciacao da bradicinina (BPF) aos inibidores da ECA by S. H Ferreira ( )
1 edition published in 1998 in Portuguese and held by 1 WorldCat member library worldwide
Handbook of experimental pharmacology ( Book )
1 edition published in 1979 in English and held by 1 WorldCat member library worldwide
Neurônio aferente primário : uma unidade funcional integrando a periferia e a medula espinal by Luiz Fernando Ferrari ( Book )
1 edition published in 2004 in Portuguese and held by 1 WorldCat member library worldwide
A administração de drogas via intratecal visa a verificação de efeitos sobre os neurônios da medula espinal, considerados pertencentes ao sistema nervoso central. Porém, drogas injetadas por essa via penetram no espaço subaracnóide e a possibilidade de exercerem efeitos em outras estruturas presentes neste espaço, envolvidas pela membrana aracnóide, como as raízes aferentes e os gânglios da raiz dorsal (GRDs), não pode ser descartada. Neste contexto, o presente estudo objetivou primeiramente verificar os locais atingidos por drogas administradas no espaço subaracnóide por meio de injeções intratecais (i.t.) do corante biológico Azul de Pontamina nos volumes correspondentes aos usados em experimentos farmacológicos, 10 e 20'mü'l. Após acesso cirúrgico, foi observado que, em ambos os volumes, substâncias administradas via intratecal podem atingir não somente a medula espinal, mas diretamente as raízes aferentes primárias e os gânglios da raiz dorsal. Além disso, a difusão do corante em direção rostral atingindo, em alguns casos, estruturas superiores como o cerebelo, também foi verificada. Assim, a partir destes dados, levantamos a possibilidade de que drogas administradas via intratecal podem exercer efeitos tanto sobre os neurônios aferentes primários através dos GRDs e raízes aferentes quanto em neurônios de segunda ordem, situados rostralmente em relação aos primeiros, o que pode influenciar a interpretação de resultados de expe
Participação do neurônio aferente primário na antinocicepção de agonistas opióides administrados por via intraplantar e intratecal by Mani Indiana Funez ( Book )
1 edition published in 2004 in Portuguese and held by 1 WorldCat member library worldwide
Na tentativa de dissociar efeitos analgésicos de efeitos indesejados dos opióides algumas estratégias têm sido estudadas, dentre elas síntese de agonistas específicos para os subtipos de receptores ou ainda agonistas que não sejam capazes de cruzar a barreira hematoencefálica além da administração destas drogas por vias alternativas. Neste contexto, este estudo objetivou 1) identificar o possível efeito antinociceptivo de agonistas opióides capa ('capa'), o U50488 e o ICI204448 (o qual não cruza a barreira hematoencefálica), administrados por via intraplantar (ipl) ou intratecal (it); 2) confirmar sua especificidade; 3) comparar seus efeitos com os efeitos da morfina; 4) também investigar a participação da via metabólica L -arginina/NO/GMPc nos efeitos antinociceptivos de agonistas 'capa' (ipl ou it) e da morfina (it) e 5) investigar a contribuição do neurônio aferente primário para o efeito antinociceptivo de opióides administrados it. Para a realização de nossos protocolos experimentais utilizamos um modelo de hipernocicepção mecânica induzida por 'PGE IND. 2' em patas de ratos que mimetiza hiperalgesia inflamatória em humanos. As injeções ipl ou it de morfina (0.7-6 ug) e agonistas 'capa', em doses que não afetam o comportamento locomotor dos animais (10-40 ug), induziram antinocicepção significativa. O efeito destes agonistas foi restrito ao sítio de injeção, visto que não se observou efeito antinociceptivo nas patas contralater
Handbook of experimental pharmacology ( Book )
1 edition published in 1978 in English and held by 1 WorldCat member library worldwide
Medicamentos a partir de plantas medicinais no Brasil ( Book )
1 edition published in 1998 in Portuguese and held by 1 WorldCat member library worldwide
Handbuch der experimentellen Pharmakologie by B. B Brodie ( Book )
1 edition published in 1979 in English and held by 1 WorldCat member library worldwide
Handbuch der experimentellen Pharmakologie / Handbook of experimental pharmacology ( Book )
in English and held by 0 WorldCat member libraries worldwide
Nimesulide : a multifactorial therapeutic approach to the inflammatory process? : a 7-year clinical experience : proceedings of the International Congress on Nimesulide held in Berlin, October 1-3, 1992 by International Congress on Nimesulide ( Book )
1 edition published in 1993 in English and held by 0 WorldCat member libraries worldwide
 
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Alternative Names
Ferreira, Sérgio Henrique 1934-
Languages
English (10)
Portuguese (8)
German (1)