WorldCat Identities

Thoenen, H. (Hans)

Overview
Works: 31 works in 62 publications in 3 languages and 507 library holdings
Genres: Conference papers and proceedings 
Roles: Editor, Author, Contributor
Classifications: QP905, 615.78
Publication Timeline
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Most widely held works about H Thoenen
 
Most widely held works by H Thoenen
6-Hydroxydopamine and catecholamine neurons by Torbjörn Malmfors( Book )

12 editions published in 1971 in English and Dutch and held by 244 WorldCat member libraries worldwide

Neurodegenerative disorders : mechanisms and prospects for therapy by Dahlem Workshop on New Biological Approaches to Neurological Disorders: Pathogenesis and Treatment( Book )

8 editions published in 1991 in English and held by 90 WorldCat member libraries worldwide

Bildung und funktionelle Bedeutung adrenerger Ersatztransmitter by H Thoenen( Book )

10 editions published between 1969 and 2013 in German and held by 65 WorldCat member libraries worldwide

Die morphologische Beeinflussung der Struktur der Schilddrüse, insbesondere der Adenome, durch die Jodprophylaxe des Kropfes by H Thoenen( Book )

3 editions published in 1957 in German and held by 16 WorldCat member libraries worldwide

The role of fast transport in the nervous system by NRP Work Session( Book )

3 editions published in 1981 in English and held by 7 WorldCat member libraries worldwide

The role of fast transport in the nervous system by H Thoenen( Book )

1 edition published in 1981 in English and held by 3 WorldCat member libraries worldwide

Entwicklungsneurobiologie; von der deskriptiven Analyse zum molekularen Verständnis by H Thoenen( Book )

1 edition published in 1985 in German and held by 2 WorldCat member libraries worldwide

Die morphologische Beeinflussung der Struktur der Schilddrüse, insbesondere der Adenome, durch die Jodprophylaxe des Kropfes. Diss. med. Bern 1957 by H Thoenen( Book )

1 edition published in 1957 in German and held by 1 WorldCat member library worldwide

The Role of fast transport in the nervous system( Book )

1 edition published in 1982 in English and held by 1 WorldCat member library worldwide

Nerve growth factor in mouse and rat serum : correlation between bioassay and radioimmunoassay determinations( )

1 edition published in 1978 in English and held by 1 WorldCat member library worldwide

High levels of nerve growth factor (NGF) determined by competition radioimmunoassay do not agree with values obtained by bioassay. This discrepancy is illustrated here with rat and mouse serum as examples in which values up to 1000 ng/ml have been found by using competition radioimmunoassays. An explanation for the discordant results is presented: serum components bind NGF with an intermediate affinity (Kd = 10(-7) M) but with a very large capacity (up to 0.5 mg of NGF per ml of rat serum). The binding of 125I-labeled NGF to serum components competes with the binding to the solid-phase antibodies (Kd = 10(-9)M) present in limiting amounts, according to the principle of competition radioimmunoassays. Thus, less radioactivity is recovered bound to the antibodies and this gives the erroneous impression that NGF is present. To overcome this difficulty, a two-site radioimmunoassay has been developed which utilizes nonlimiting numbers of antibody binding sites. This assay provides a reliable determination of NGF levels in serum and it can be shown that in rat and mouse serum (either sex) there is less than 5 ng of NGF per ml, in agreement with the results of the bioassay
Subpopulations of cultured chick sympathetic neurones differ in their requirements for survival factors( )

1 edition published in 1981 in English and held by 1 WorldCat member library worldwide

Peripheral autonomic and sensory neurones derived from the neural crest will survive in vitro only if the culture medium is supplemented with specific factors (for review see ref. 1). For example, the nerve growth factor (NGF), although supporting the survival of sympathetic and spinal sensory neurons, is ineffective on parasympathetic neurones, whereas medium conditioned by chick heart cells (HCM) supports the survival of all three neuronal types. We showed previously that the requirements of cultured spinal sensory ganglion neurones for survival factors changed during development, and so provided a basis for the classification of such factors. We now demonstrate that cultured post-mitotic neurones from chick paravertebral sympathetic ganglia respond differentially to NGF, HCM and medium conditioned by C6 glioma cells (GCM). Thus, there three survival factors are functionally distinct in that they support the survival in culture of discrete subpopulations of sympathetic neurones. Those subpopulations responding to HCM and NGF are shown to differ not only in their requirements for survival factors but also in their contents of the cholinergic and adrenergic marker enzymes choline acetyltransferase (ChAT) and tyrosine hydroxylase (TH)
High K+-mediated survival of spinal sensory neurons depends on developmental stage( )

1 edition published in 1987 in English and held by 1 WorldCat member library worldwide

Elevated concentrations of K+ (35 mM) have previously been shown to support the survival of most embryonic chick sympathetic neurons in vitro (Wakade et al., Exp cell res 144 (1983) 377, [23]) and to be interchangeable with nerve growth factor (NGF) as a survival-promoting agent for these cells (Wakade & Thoenen, Neurosci lett 45 (1984) 71 [21]). In the present study, we show that dorsal root ganglion (DRG) neurons from embryonic day 6 do not survive in the presence of high K+, although both NGF and brain-derived neurotrophic factor (BDNF) each support the survival of more than 50% of the cells at this developmental stage. At E6, high K+ appears to have a cytotoxic effect on BDNF-dependent neurons, and there is also considerable inhibition of neurite outgrowth. At a later developmental stage (E12), high K+ supports the survival of about 40% of DRG cells. This subpopulation of neurons is distinct from that supported by NGF (as evidenced by the additivity of these two agents), but partially overlaps with that supported by BDNF (i.e., the two agents are less than additive). At E12, only approx. 20% of the cells can be supported by either NGF or BDNF, with the rest depending exclusively on one or the other of these factors. This is in contrast to the situation at E6, where there is considerable overlap between NGF- and BDNF-dependent populations
Six-Hydroxydopamine and catecholamine neurons. Editors: T. Malmfors and H. Thoenen by Torbjörn Malmfors( Book )

1 edition published in 1971 in English and held by 1 WorldCat member library worldwide

Purification of a new neurotrophic factor from mammalian brain( )

1 edition published in 1982 in English and held by 1 WorldCat member library worldwide

We report the purification from pig brain of a factor supporting the survival of, and fibre outgrowth from, cultured embryonic chick sensory neurons. The purified factor migrates as one single band, mol. wt. 12 300, on gel electrophoresis in the presence of sodium dodecylsulphate (SDS) and is a basic molecule (pI greater than or equal to 10.1). Approximately 1 microgram factor was isolated from 1.5 kg brain. The final degree of purification was estimated to be 1.4 X 10(6)-fold, and the specific activity 0.4 ng/ml/unit, which is similar to that of nerve growth factor (NGF) using the same assay system. This factor is the first neurotrophic factor to be purified since NGF, from which it is clearly distinguished because it has different antigenic and functional properties
Neurosciences Research Program bulletin( Book )

1 edition published in 1981 in English and held by 1 WorldCat member library worldwide

Physiology of nerve growth factor( )

1 edition published in 1980 in English and held by 1 WorldCat member library worldwide

Different factors from the central nervous system and periphery regulate the survival of sensory neurones( )

1 edition published in 1986 in English and held by 1 WorldCat member library worldwide

Work on nerve growth factor has established that the survival of developing vertebrate neurones depends on the supply of a neurotrophic factor from their target field. The discovery of several new neurotrophic factors has raised the possibility that neurones which innervate multiple target fields require several different neurotrophic factors for survival. Here we show that two distinct neurotrophic factors, one in the central nervous system (CNS) and the other in skeletal muscle, promote the survival of proprioceptive neurones in culture. At saturating concentrations, either factor alone supported most neurones and there was no additional survival in the presence of both factors, but at subsaturating concentrations the combined effect was additive. The neurotrophic activity of each factor was greatest during the period of natural neuronal death. Our results demonstrate that each cultured proprioceptive neurone responds to two distinct neurotrophic factors present in its respective central and peripheral target fields, and suggest that these factors cooperate in regulating survival during development
6-hydroxydopamine and catecholamine neurons, eds: T. malmfors( Book )

in English and held by 1 WorldCat member library worldwide

Catecholamines by H. K. F Blaschko( )

1 edition published in 1972 in English and held by 0 WorldCat member libraries worldwide

 
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Neurodegenerative disorders : mechanisms and prospects for therapy
Languages
English (36)

German (15)

Dutch (1)

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