WorldCat Identities

Michel, T.

Overview
Works: 7 works in 16 publications in 3 languages and 30 library holdings
Genres: Juvenile works  Fiction 
Roles: Author, Contributor, Composer, Arranger
Publication Timeline
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Most widely held works by T Michel
A Will and a way. : Tales translated from the German of T. Michel and Aug. Moritz. by T Michel( Book )

10 editions published between 1859 and 1867 in English and held by 15 WorldCat member libraries worldwide

Schützenhaus in Basel : Gesellschaftshaus E.E. Gesellschaft der Feuerschützen by Th Michel( Book )

1 edition published in 1963 in German and held by 9 WorldCat member libraries worldwide

Targeting and translocation of endothelial nitric oxide synthase by T Michel( )

1 edition published in 1999 in English and held by 2 WorldCat member libraries worldwide

This review explores advances in our understanding of the intracellular regulation of the endothelial isoform of nitric oxide synthase (eNOS) in the context of its dynamically regulated subcellular targeting. Nitric oxide (NO) is a labile molecule, and may play important biological roles both within the cell in which it is synthesized and in its interactions with nearby cells and molecules. The localization of eNOS within the cell importantly influences the biological role and chemical fate of the NO produced by the enzyme. eNOS, a Ca2+/calmodulin-dependent enzyme, is subject to a complex pattern of intracellular regulation, including co- and post-translational modifications and interactions with other proteins and ligands. In endothelial cells and cardiac myocytes eNOS is localized in specialized plasmalemmal signal-transducing domains termed caveolae; acylation of the enzyme by the fatty acids myristate and palmitate is required for targeting of the protein to caveolae. Targeting to caveolae facilitates eNOS activation following receptor stimulation. In resting cells, eNOS is tonically inhibited by its interactions with caveolin, the scaffolding protein in caveolae. However, following agonist activation, eNOS dissociates from caveolin, and nearly all the eNOS translocates to structures within the cell cytosol; following more protracted incubations with agonists, most of the cytosolic enzyme subsequently translocates back to the cell membrane. The agonist-induced internalization of eNOS is completely abrogated by chelation of intracellular Ca2+. These rapid receptor-mediated effects are seen not only for "classic" eNOS agonists such as bradykinin, but also for estradiol, indicating a novel non-genomic role for estrogen in eNOS activation. eNOS targeting to the membrane is labile, and is subject to receptor-regulated Ca2+-dependent reversible translocation, providing another point for regulation of NO-dependent signaling in the vascular endothelium. (Au)
Le Maire d'Eu. Chanson, paroles de Vatout. (1842.) Air local, arrangé pour piano par T. Michel by T Michel( )

1 edition published in 1915 in Undetermined and held by 1 WorldCat member library worldwide

Workshop on molecular biology and pathophysiology of nitric oxide( Book )

1 edition published in 1995 in English and held by 1 WorldCat member library worldwide

Material reconstruction with the Medipix2 detector with CdTe sensor( )

1 edition published in 2013 in English and held by 1 WorldCat member library worldwide

 
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.79 (from 0.61 for A Will and ... to 0.99 for Targeting ...)

Languages
English (13)

German (1)

French (1)