WorldCat Identities

Schmid, Sandra Louise

Overview
Works: 5 works in 11 publications in 1 language and 101 library holdings
Roles: Editor, Author
Publication Timeline
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Most widely held works by Sandra Louise Schmid
Endocytosis : a subject collection from Cold Spring Harbor perspectives in biology( Book )

4 editions published in 2014 in English and held by 95 WorldCat member libraries worldwide

In vitro reconstitution and characterization of uncoating ATPase : an enzyme that catalyzes the release of clathrin from coated vesicles and empty cages by Sandra Louise Schmid( )

4 editions published in 1985 in English and held by 3 WorldCat member libraries worldwide

Coats, collars, and accessories : the elegance of the cell's endocytic machinery by Sandra Louise Schmid( Visual )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Sandra Schmid, Ph. D., Professor and Chair of the Department of Cell Biology at UT Southwestern Medical Center, is considered by her colleagues as a transformative thinker during a time of unprecedented change -- both in her field and in the world of science. Dr. Schmid discussed her dynamic field of study -- endocytosis -- during the President's Lecture Series on April 30, 2015
Guidelines for a successful postdoc experience at TSRI by Sandra Louise Schmid( Visual )

1 edition published in 2008 in English and held by 1 WorldCat member library worldwide

Protecting your borders : regulated entry into the cell by Sandra Louise Schmid( Visual )

1 edition published in 2010 in English and held by 1 WorldCat member library worldwide

(CIT): Cells communicate with their environment and with other cells through their plasma membranes (PM). The major selective pathway for internalization from the plasma membrane is clathrin-mediated endocytosis (CME), which involves the assembly of clathrin coated pits (CCPs) that package cargo molecules, invaginate and pinch off into the cytosol forming clathrin coated vesicles (CCVs). CME governs key cellular processes, including uptake of nutrients, regulation of surface signaling receptors, recycling of synaptic vesicles, and remodeling of PM transporters to control serum homeostasis. Given its importance to cell and organismal physiology, CME is tightly regulated. We have used quantitative total internal reflection fluorescence microscopy to study CCP dynamics in living cells and identified an endocytosis "checkpoint" that is sensitive to cargo content and regulated by the GTPase dynamin. Dynamin also catalyzes the membrane fission event leading to CCV formation. We have reconstituted dynamin-catalyzed vesicle formation from fluid supported bilayers with excess membrane reservoir (SUPER) templates to gain insight into the mechanisms governing membrane fission. Further insights come from structural studies on the dynamin GTPase domain. Together, these in vivo and in vitro approaches provide evidence that dynamin plays a dual role in CME, functioning at early stages to regulate CCV formation and at later stages to directly mediate membrane fission. Supported by NIH GM42455, GM73165, MH61345 The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide
 
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.64 (from 0.17 for Coats, col ... to 0.96 for Protecting ...)

Languages
English (11)