WorldCat Identities

Agre, Peter 1949-

Overview
Works: 18 works in 40 publications in 1 language and 1,057 library holdings
Genres: Conference papers and proceedings 
Roles: Editor, Author, Contributor, Other
Classifications: QP552.C34, 572.69
Publication Timeline
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Most widely held works by Peter Agre
Aquaporins( Book )

5 editions published in 2001 in English and held by 172 WorldCat member libraries worldwide

Aquaporins summarizes the present knowledge in this expanding field of research, starting with the structural analysis of water channel proteins. Subsequent chapters begin with mammalian aquaporins, examining physiology and pathophysiology, analysis of knock-out model animals, and the regulation of aquaporin function. Also covered is the distribution and regulation of aquaporins in plants and the function of water and glycerol channels in microbial systems
Red blood cell membranes : structure, function, clinical implications( Book )

5 editions published in 1989 in English and held by 168 WorldCat member libraries worldwide

Protein blood group antigens of the human red cell : structure, function, and clinical significance( Book )

4 editions published in 1992 in English and held by 133 WorldCat member libraries worldwide

Aquaporins by Eric Beitz( Book )

8 editions published between 2008 and 2009 in English and held by 74 WorldCat member libraries worldwide

The aquaporin field has matured at an exceptionally fast pace and we are at the verge to develop serious strategies to therapeutically modulate aquaporin function directly or via regulatory networks. Key prerequisites are available today: i. a considerable (and growing) number of aquaporin crystal structures for the rational design of inhibitory molecules, ii. elaborate molecular dynamics simulation techniques for theoretical analyses of selectivity mechanisms and docking experiments, iii. comprehensive data on aquaporin immunohistochemistry, iv. aquaporin knockout animals for physiological studies, and v. assay systems for compound library screenings. The structure of this volume on aquaporins follows the points laid out above and thus covers the developments from basic research to potential pharmacological use. Situated between pharmacology textbooks and recent scientific papers this book provides a timely overview for readers from the fundamental as well as the applied disciplines
Brain water homeostasis( Book )

3 editions published in 2004 in English and held by 3 WorldCat member libraries worldwide

Maryland LISP reference manual by Philip Agre( Book )

2 editions published in 1978 in English and held by 3 WorldCat member libraries worldwide

Aquaporin water channels : from transfusion medicine to malaria by Peter Agre( Visual )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

(CIT): NIH Director's Wednesday Afternoon Lecture Series Biochemical analysis of the Rhesus blood group antigen led to the serendipitous discovery of AQP1, the first molecular water channel. Found throughout nature, aquaporin water channels confer high water permeability to cell membranes. AQP1 has been characterized biophysically, and the atomic structure of AQP1 is known. Identification of the Colton blood group antigen on the extracellular domain of AQP1 allowed identification of rare individuals who are AQP1-null and manifest a subclinical form of nephrogenic diabetes insipidus. Thirteen homologous proteins exist in humans. Some transport only water (aquaporins); others transport water plus glycerol (aquaglyceroporins). These proteins are required for generation of physiological fluids (urine, cerebrospinal fluid, aqueous humor, sweat, saliva, and tears). Involvement of aquaporins in multiple clinical states is becoming recognized--renal concentration, fluid retention, blindness, skin hydration, brain edema, thermal stress, glucose homeostasis, malaria, and even arsenic poisoning. Aquaporins are particularly important in plant biology. This information now provides the challenge of developing new technologies to manipulate aquaporins for clinical or agricultural benefits
Progress on the structure and function of aquaporin 1( )

1 edition published in 1998 in English and held by 1 WorldCat member library worldwide

Life exists in water as universal solvent, and cells need to deal with its influx and efflux. Nature has accomplished the almost impossible, creating membrane channels with both a high flux and a high specificity for water. The first water channel was discovered in red blood cell membranes. Today known as aquaporin-1, this channel was found to be closely related to the major integral protein (MIP)1 of the eye lens. Cloning and sequencing of numerous related proteins of the MIP family revealed the widespread occurrence of such channels, suggesting an essential physiological function. Their structures hold the clues to the remarkable water channel activity, as well as to the arrangement of transmembrane segments in general. Recent medium-resolution three-dimensional electron microscopic studies determined a tetrameric complex with six tilted transmembrane helices per monomer. The helices within each monomer surround a central density formed by two interhelical loops implicated by mutagenesis in the water channel function. A combination of sequence analysis and assignment of the observed densities to predicted helices provides a basis for speculation on the nature of the water course through the protein. In particular, four highly conserved polar residues, E142-N192-N76-E17, are proposed to form a chain of key groups involved in the pathway of water flow through the channel
Aquaporin water channels by Peter Agre( )

1 edition published in 2003 in English and held by 1 WorldCat member library worldwide

Current topics in membranes( Book )

2 editions published in 2001 in English and held by 1 WorldCat member library worldwide

Aquaporins summarizes the present knowledge in this expanding field of research, starting with the structural analysis of water channel proteins. Subsequent chapters begin with mammalian aquaporins, examining physiology and pathophysiology, analysis of knock-out model animals, and the regulation of aquaporin function. Also covered is the distribution and regulation of aquaporins in plants and the function of water and glycerol channels in microbial systems
Handbook of experimental pharmacology( Book )

1 edition published in 2009 in English and held by 1 WorldCat member library worldwide

Opening doors worldwide through medical science by Peter Agre( Visual )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

(CIT): The major lesson I learned from a four-decade career in medical science is that we have a unique opportunity to make the world a better place. As a Johns Hopkins faculty member, our research group discovered the aquaporin water channels that facilitate the movement of water across cell membranes. This led to multiple international collaborations including studies with renal physiologists in Denmark, neuroscientists in Norway, structural biologists in Switzerland and Japan, and field workers in Africa. While the practical value of these discoveries is just emerging, valuable new preventive strategies and treatments for multiple disorders are anticipated, including renal failure, brain edema, blindness, wound healing, and infectious diseases. In addition to achievements in the laboratory and clinic, the human contacts we have developed have proven useful to address serious infringements of human rights and may even open doors to countries isolated by ideology or repressive regimes
Aquaporins (Handbook of experimental pharmacology ; v. 190) by Peter Agre( Book )

1 edition published in 2009 in Undetermined and held by 1 WorldCat member library worldwide

Aquaporin water channels--from atomic structure to clinical medicine( )

1 edition published in 2002 in English and held by 1 WorldCat member library worldwide

The water permeability of biological membranes has been a longstanding problem in physiology, but the proteins responsible for this remained unknown until discovery of the aquaporin 1 (AQP1) water channel protein. AQP1 is selectively permeated by water driven by osmotic gradients. The atomic structure of human AQP1 has recently been defined. Each subunit of the tetramer contains an individual aqueous pore that permits single-file passage of water molecules but interrupts the hydrogen bonding needed for passage of protons. At least 10 mammalian aquaporins have been identified, and these are selectively permeated by water (aquaporins) or water plus glycerol (aquaglyceroporins). The sites of expression coincide closely with the clinical phenotypes--ranging from congenital cataracts to nephrogenic diabetes insipidus. More than 200 members of the aquaporin family have been found in plants, microbials, invertebrates and vertebrates, and their importance to the physiology of these organisms is being uncovered
The importance of aquaporin water channel protein structures( )

1 edition published in 2000 in English and held by 1 WorldCat member library worldwide

The history of the water channel and recent structural and functional analyses of aquaporins are reviewed. These ubiquitous channels are important for bacteria, plants and animals, exhibit a pronounced sequence homology and share functional as well as structural similarities. Aquaporins allow water or small specific solutes to pass unhindered, but block the passage of ions to prevent dissipation of the transmembrane potential. Besides advances in structure determination, recent experiments suggest that many of these channels are regulated by pH variations, phosphorylation and binding of auxiliary proteins
Aquaporin water channels : from atomic structure to clinical medicine( Visual )

1 edition published in 2005 in English and held by 1 WorldCat member library worldwide

Infrastructure and institutional change in the networked university by Peter Agre( Book )

1 edition published in 1999 in English and held by 0 WorldCat member libraries worldwide

 
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AquaporinsCurrent topics in membranes
Alternative Names
Agre, P. 1949-

Agre, Peter C.

Agre, Peter Courtland 1949-

Peter Agre Amerikaans moleculair bioloog en Nobelprijswinnaar

Peter Agre amerykański, biochemik

Peter Agre biologo statunitense

Peter Agre Nobel Prize winner in chemistry, Distinguished Eagle Scout

Peter Agre quimico, profesor y biólogo molecular

Peter Agre US-amerikanischer Molekularbiologe und Nobelpreisträger für Chemie

Peter Courtland Agre

Питер Агре

Питър Агре

Пітер Егр

Пітэр Эгр

Эгр, Питер

פיטר אגרה

بيتر أغري

پیتر آگره

پیتەر ئەگری

پیٹر اگری

پیٹر ایجر

पीटर एग्रे

পিটার অ্যাগর Nobel Prize winner in chemistry, Distinguished Eagle Scout

ピーター・アグレ

彼得·阿格雷

Languages
English (39)

Covers
Red blood cell membranes : structure, function, clinical implicationsAquaporinsCurrent topics in membranesHandbook of experimental pharmacology