WorldCat Identities

Beutler, Bruce

Overview
Works: 23 works in 59 publications in 2 languages and 1,166 library holdings
Genres: Filmed lectures  Nonfiction films 
Roles: Speaker, Editor, Author, Creator, Other
Publication Timeline
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Most widely held works about Bruce Beutler
 
Most widely held works by Bruce Beutler
Immunology, phenotype first : how mutations have new principles and pathways in immunology by Bruce Beutler( )

18 editions published between 2007 and 2010 in English and held by 604 WorldCat member libraries worldwide

This monograph deals with the impact of classical genetics in immunology, providing examples of how large immunological questions were solved, and new fields opened to analysis through the study of phenotypes, either spontaneous or induced. As broad as biology has become, there are those who dona (TM)t fully understand what the genetic approach is, and how it differs fundamentally from most of the methods available to natural scientists. They may hold the opinion that genetics has run its course since Mendel read his paper on peas in 1865. a oeWhy bother with classical genetics, a they may ask
Toll-like receptor family members and their ligands( Book )

9 editions published in 2002 in English and held by 269 WorldCat member libraries worldwide

The innate immune system is sometimes referred to as the "primitive" immune system. Perhaps this has dissuaded immunologists from analyzing it so energetically as they have analyzed the adaptive immune system during the past two decades. But while its phylogenetic origins are indeed ancient, and though it is "of the first type", there is nothing crude, nothing unsophisticated, and nothing "inferior" about innate immunity. On the contrary, the innate immune system has had time to achieve a level of refinement that is nothing short of dazzling, and a modicum of respect is at long last due
Tumor necrosis factors : the molecules and their emerging role in medicine( Book )

9 editions published between 1991 and 1992 in English and held by 216 WorldCat member libraries worldwide

Innate immune sensing and response by Bruce Beutler( Visual )

3 editions published in 2009 in English and held by 52 WorldCat member libraries worldwide

Immunology, Phenotype First by Bruce Beutler( )

1 edition published in 2008 in English and held by 8 WorldCat member libraries worldwide

This monograph deals with the impact of classical genetics in immunology. It provides examples of how large immunological questions were solved, and new fields opened to analysis through the study of phenotypes, either spontaneous or induced
Direct Detection of Microbial Infection Through Activation Coupling of the Toll-Like Receptors( Book )

2 editions published in 2004 in English and held by 2 WorldCat member libraries worldwide

We have utilized germline mutagenesis to dissect innate immune sensing and effector pathways, and have made a number of important findings related to the mechanism of TLR signal transduction. In particular, we were able to solve the molecular basis of MyD88-independent signaling. and to determine the cause of adjuvanticity (signaling via Trif and the production of type I interferons). Finally, our work has led to the first realization of the importance of the TLR9 -> MyD88 signaling axis and the TLR3 -> Trif signaling axis in responses to MCMV. These discoveries have important implications for the further study of innate resistance to both viral and bacterial infections, for the development of vaccines, and for the design of molecular sensors of infection
Kleinere Beiträge, Berichte und Dokumente : der Sitz der Organe der Gemeinschaft by B Beutler( )

1 edition published in 1983 in German and held by 1 WorldCat member library worldwide

Toll-like receptor family members and their ligands, with 31 figures and 5 tables( Book )

1 edition published in 2002 in English and held by 1 WorldCat member library worldwide

Mehr Macht durch Recht? : das Europäische Parlament vor dem Europäischen Gerichtshof by B Beutler( )

1 edition published in 1984 in German and held by 1 WorldCat member library worldwide

Diskussion der Stellung des Europäischen Parlaments in der Gemeinschaftsrechtsordnung. Beteiligung des Parlaments in Verfahren vor dem Gerichtshof. Rechtsprechung des EUGH zur Stellung des EP. Das Parlamentsbild in der Rechtsprechung des Gerichtshofes.--SCAD summary
How we sense microbes by Bruce Beutler( Visual )

1 edition published in 2007 in English and held by 1 WorldCat member library worldwide

(CIT): The Kinyoun Lecture The less you understand, the better forward genetics works, says Bruce Beutler, M.D., describing the technique he has used to unveil fundamental actions of the immune system. Forward genetics starts when scientists observe a novel trait or appearance in a mouse or other model organism, and then turn to the search for the responsible gene or genes. What this approach may tell us about how mammals detect infection is the topic of the 2007 Joseph J. Kinyoun lecture. Beutler, of The Scripps Research Institute (TSRI) in La Jolla, California, will present his lecture "How We Sense Microbes." At the core of immunology, notes Beutler, is the question of how we distinguish self from non-self. Ever since microbes were recognized as the cause of infectious disease, a corollary seemed obvious: plants, animals, and people must have ways to sense and respond to invading (non-self) microbes. For example, says Beutler, researchers observed decades ago that mammals react swiftly and dramatically to injections of what was originally called endotoxin a component of many bacterial cell walls now known to be a lipopolysaccharide (LPS). It was also observed years ago that some strains of mutant mice failed to react at all to LPS, adds Beutler, implying that the mice lacked a sensor. But the identity of the putative LPS sensor remained elusive, he says. In 1998, Beutler, who was then at the University of Texas, Southwestern, and his colleagues used forward genetics to explain the mutant animals inability to detect LPS. The researchers determined that the mice had mutations in the Lps gene, which eliminated the action of Toll-like receptor 4 (TLR4) protein and caused the mice to be insensitive to LPS. The finding, published in Science, was the first demonstration of an infection-sensing role for a mammalian TLR protein. The paper is regarded as a seminal contribution to understanding innate immunity. Bruce Beutler, M.D., Professor and Chairman of the Department of Genetics and Professor of Immunology, The Scripps Research Institute, La Jolla, CA
Der Schutz der Vertraulichkeit zwischen Anwalt und Mandanten im europäischen Recht by B Beutler( )

1 edition published in 1982 in German and held by 1 WorldCat member library worldwide

From TNF to TLRs : how the innate immune system senses infection by Bruce Beutler( Visual )

1 edition published in 2013 in English and held by 1 WorldCat member library worldwide

Infections comprise the strongest selective pressure operating on our species, and indeed, since multicellular life evolved, unicellular organisms have challenged their integrity. A system for discriminating self from non-self arose in pre-Cambrian times and was transmitted into all vertebrate lines, into some insects, and into some plants. The Toll-like receptors (TLRs) of mammals directly recognize conserved structures from bacteria, viruses, and fungi, initiating a powerful inflammatory response. The prototypic example was Toll-like receptor 4 (TLR4), which was found to be the membrane-spanning subunit of the receptor for lipopolysaccharide (LPS, once known as 'endotoxin'). A total of 10 TLRs have been found to function in humans, each recognizing a specific subset of molecules of microbial origin. Moreover, the signaling pathways used by TLRs have been deciphered in considerable detail. If TLR signaling is abolished by mutations, a state of immunocompromise results, because immune responses are not initiated in a timely manner. However, under certain conditions, endogenous molecules may trigger TLR activation and cause sterile inflammatory or autoimmune diseases
Der Beitritt Grossbritanniens zur Europäischen Gemeinschaft by B Beutler( )

1 edition published in 1975 in German and held by 1 WorldCat member library worldwide

Sensing infection : toll-like receptors & the genetic analysis of mammalian innate immunity( Visual )

1 edition published in 2006 in English and held by 1 WorldCat member library worldwide

Microbes, 'Merican mice, and French flies : how your resistome recognizes and fights infection by Bruce Beutler( Visual )

1 edition published in 2013 in English and held by 1 WorldCat member library worldwide

How exactly do insects thousands of miles away in Europe and rodents studied for years in an American laboratory intersect to provide the secrets of how the immune system senses infection and fights back? Bruce A. Beutler, M.D., accomplished pioneering research at UT Southwestern that helped explain some age-old medical puzzles, including: "How do we 'know' when we have an infection? What are the receptors that alert us? How do we discriminate self from nonself, and why does the immune system sometimes attack our own cells and tissues?" While at the Medical Center, the Nobel Laureate successfully identified the family of Toll-like receptors that enable mammals to sense infection and to launch a powerful inflammatory response. Dr. Beutler's talk will include details of how his research on mice converged with French scientist Dr. Jules A. Hoffman's studies in flies to reveal the fundamental framework by which creatures sense infection
Forward genetic analysis of mammalian immunity by Owen M Siggs( )

1 edition published in 2012 in English and held by 1 WorldCat member library worldwide

These include genes encoding the following proteins: the inactive rhomboid protease iRhom2, which is specifically required for the secretion of tumour necrosis factor alpha; the hypothetical phospholipid flippase ATP11C, required for B cell development in the adult bone marrow; the folliculin-interacting protein FNIP1, also required for B cell development; and the zinc finger transcription factor ZBTB1, essential for the development of all lymphocyte lineages. These findings uncover new entry points for the understanding of mammalian immunity, and highlight the value of mouse forward genetics in the understanding of mammalian phenomena in general
How mammals sense infection : toll-like receptors and the genetic analysis of innate immunity by Bruce Beutler( Visual )

1 edition published in 2006 in English and held by 1 WorldCat member library worldwide

Innate immune sensing and response by Bruce Beutler( Book )

1 edition published in 2009 in English and held by 1 WorldCat member library worldwide

 
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Immunology, phenotype first : how mutations have new principles and pathways in immunology
Covers
Toll-like receptor family members and their ligandsToll-like receptor family members and their ligands, with 31 figures and 5 tables
Alternative Names
Beutler, B.

Beutler, Bruce Alan 1957-

Bruce A. Beutler

Bruce Alan Beutler

Bruce Beutler

Bruce Beutler American immunologist and geneticist

Bruce Beutler americký imunolog a genetik

Bruce Beutler Amerikaans arts

Bruce Beutler amerikanischer Immunologe und Genetiker

Bruce Beutler amerykański immunolog i genetyk

Bruce Beutler biologo statunitense

Bruce Beutler dokter asal Amerika Serikat

Brus Bojtler

Brüs Bötler

Brūss Betlers

Brussius Beutler

Брус Бётлер

Брус Бойтлер

Брус Бојтлер

Брюс Бётлер

ברוס בויטלר

ברוס בויטלר אימונולוג וגנטיקאי אמריקאי

بروس بوتلر

بروس بویتلر

بروس بٹلر

بروس بیوٹلر

ব্রুশ বিউটলার

புரூஸ் பொய்ட்லர்

บรูซ เอ. บีทเลอร์

브루스 보이틀러

ブルース・ボイトラー

布鲁斯·博伊特勒

布魯斯·比尤特勒

Languages
English (52)

German (4)