WorldCat Identities

Baldwin, Thomas O.

Overview
Works: 18 works in 58 publications in 1 language and 1,192 library holdings
Genres: Conference proceedings 
Roles: Editor
Classifications: QP601, 574.192508 S
Publication Timeline
Key
Publications about  Thomas O Baldwin Publications about Thomas O Baldwin
Publications by  Thomas O Baldwin Publications by Thomas O Baldwin
Most widely held works by Thomas O Baldwin
Molecular chaperones by G. H Lorimer ( Book )
13 editions published in 1998 in English and held by 522 WorldCat member libraries worldwide
The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 285 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. Key Features * Catalysts of Protein Folding: Protein Disulfide Isomerases, Cis-trans Peptidyl Prolyl Isomerases * Accessory Proteins: Chaperonins, Cochaperonins, Pap Proteins, Sec Proteins * Physical methods for investigation of interactions between chaperones and their substances * Cotranslational protein folding, cell-free protein synthesis and associated methods
Bioluminescence and chemiluminescence by Miriam M Ziegler ( Book )
24 editions published between 1978 and 2000 in English and held by 361 WorldCat member libraries worldwide
Since the publication of Bioluminescence and Chemiluminescence, Part B, genes have been cloned that encode luciferases from an array of bioluminescent organisms, novel applications of these genes have been developed, and much has been learned of the fundamental chemistry, biochemistry, structural biology, and biophysics of these intriguing enzymes. New strategies for application of chemiluminescence technology have been developed and refined, promising to further reduce the need to use radioisotopes in basic research and clinical laboratory settings. Methods for detection of low levels of ligh
Chemical aspects of enzyme biotechnology : fundamentals by IUCCP Symposium on Chemical Aspects of Enzyme Biotechnology: Fundamentals Texas A & M University ( Book )
6 editions published between 1990 and 1991 in English and held by 155 WorldCat member libraries worldwide
Applications of enzyme biotechnology by IUCCP Symposium on Applications of Enzyme Biotechnology Texas A & M University ( Book )
1 edition published in 1991 in English and held by 134 WorldCat member libraries worldwide
Methods of enzymology. V.305 Bioluminescence and chemiluminescence ( Book )
1 edition published in 2000 in English and held by 1 WorldCat member library worldwide
Methods in enzymology. ( Book )
1 edition published in 2000 in English and held by 1 WorldCat member library worldwide
Chemical aspects of enzyme biotechnology : fundamentals : 8th Annual symposium : Papers ( Book )
1 edition published in 1991 in English and held by 1 WorldCat member library worldwide
Methods in enzymology ( Book )
1 edition published in 1998 in English and held by 1 WorldCat member library worldwide
Applications of enzyme biotechnology : 9th Annual symposium : Papers ( Book )
1 edition published in 1991 in English and held by 1 WorldCat member library worldwide
Bioluminescence and Chemiluminescence, Part C. Volume 305, Methods in Enzymology ( )
1 edition published in 2000 in English and held by 1 WorldCat member library worldwide
Structural studies on bullfrog hemoglobin by Thomas O Baldwin ( Book )
1 edition published in 1971 in English and held by 1 WorldCat member library worldwide
Bacterial Luciferase: Determination of the Structure by X-Ray Diffraction ( )
1 edition published in 1994 in English and held by 1 WorldCat member library worldwide
This project was focused on determination of the three-dimensional structure of bacterial luciferase. The structure of the enzyme is of fundamental importance to the understanding of the catalytic mechanism and the mode of interaction of the enzyme with accessory proteins, and is essential to future plans to develop biosensor technologies. In the course of this project, numerous crystallization trials were carried out and conditions were refined that permitted high resolution data to be collected and interpreted. In collaboration with Dr. Ivan Rayment of the University of Wisconsin, data have been collected from native crystals and 3 derivatives at 2.8 A. Higher resolution data are being collected at this time, and we fully expect to have a high resolution structure within the next few months, certainly by the end of the calendar year 1994. We have also developed crystallization protocols for several mutant luciferases. Structural analysis of the mutant luciferases should enable us to locate the active site in the three-dimensional structure of the wild-type enzyme, permit mechanistic interpretation of numerous experiments that have been reported over the past ca. 25 years, and assist us in designing the next generation of mutant enzymes to test hypotheses regarding the mechanism of light production by this intriguing and important enzyme
Structural and Functional Studies of Bioluminescent Proteins (an AASERT Grant) ( )
1 edition published in 1997 in English and held by 1 WorldCat member library worldwide
This grant provided support between September 1993 and August 1996 for the dissertation research of several predoctoral students. Highlights of their collective accomplishments include: (a) participating in the crystallization and analysis of the high resolution structures of the bacterial luciferase Alpha Beta heterodimer and the Beta2 homodimer, (b) elucidation of a detailed kinetic mechanism for the folding and assembly of the luciferase subunits, (c) use of spectroscopic techniques and mutant enzymes to probe the active site and subunit interface of bacterial luciferase, and (d) characterization by genetic methods of the role of the LuxR transcriptional activator protein in density-dependent control of gene expression
Luminescence-Based Biosensor Systems ( )
1 edition published in 1997 in English and held by 1 WorldCat member library worldwide
Progress has been made in two related areas during the period of this grant. In the area of luminescence-based biosensor systems, we have developed sensitive methods to detect antibiotics in biological materials and foods using bioluminescence. We believe that our methods can be automated and applied to the rapid detection of antibiotics in biological fluids, food sources, and other materials. In related studies, the crystal structure of bacterial luciferase has been determined at 2.4 A resolution. This accomplishment represents a major step forward in our effort to understand this enzyme and how it works, including the details of its folding. Knowledge of the structure is crucial also to efforts to derivatize the enzyme for development of new generation biosensor systems
 
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Alternative Names
Baldwin, Thomas Oakley.
Languages
English (58)
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