WorldCat Identities

King, Mary Claire

Overview
Works: 27 works in 42 publications in 1 language and 543 library holdings
Genres: History  Conference proceedings  Interviews  Exhibition catalogs 
Roles: Interviewee
Classifications: GN269, 305.800973
Publication Timeline
Key
Publications about  Mary Claire King Publications about Mary Claire King
Publications by  Mary Claire King Publications by Mary Claire King
Most widely held works about Mary Claire King
 
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Most widely held works by Mary Claire King
The difference between us ( Visual )
4 editions published between 2003 and 2007 in English and held by 89 WorldCat member libraries worldwide
A three part series exploring the history of race perceptions and behaviors towards races in the United States, within the context of recent scientific discoveries which have toppled the concept of biological race. Episode one follows students who sequence and compare their own DNA looking for a "race marker." It also looks at the history of racism in the U.S., the advent of stereotypes based on physical attributes attributed to races and somatotypes with particular reference to African Americans
The difference between us ( Visual )
2 editions published between 2003 and 2013 in English and held by 31 WorldCat member libraries worldwide
A three part series exploring the history of race perceptions and behaviors towards races in the United States, within the context of recent scientific discoveries which have have toppled the concept of biological race. Episode one follows students who sequence and compare their own DNA looking for a "race marker." It also looks at the history of racism in the U.S., the advent of stereotypes based on physical attributes attributed to races and somatotypes with particular reference to African Americans
Abstracts of papers presented at the Cold Spring Harbor meeting on cancer cells : genetics and molecular biology of breast cancer, September 2-September 6, 1992 by Cold Spring Harbor, NY> Meeting on Cancer Cells Genetics and Molecular Biology of Breast Cancer. <1992 ( Book )
2 editions published in 1992 in English and held by 26 WorldCat member libraries worldwide
Abstracts of papers presented at the 2002 meeting on human origins & disease, October 30-November 3, 2002 ( Book )
1 edition published in 2002 in English and held by 16 WorldCat member libraries worldwide
Abstracts of papers presented at the 2008 meeting on personal genomes: October 9-October 12, 2008 ( Book )
1 edition published in 2008 in English and held by 10 WorldCat member libraries worldwide
Genetic Alterations in Familiar Breast Cancer: Mapping and Cloning Genes Other than BRCAl ( )
4 editions published between 1995 and 1997 in English and held by 4 WorldCat member libraries worldwide
The purpose of this project was to identify genes responsible for inherited predisposition to breast cancer in families. The gene PTEN was successfully cloned by this project, and simultaneously by others (for a different reason) and proved to be such a gene. This project indicated that inherited mutations in PTEN predispose to breast cancer in women with the rare Cowden's syndrome. However, symptoms of that syndrome may be very subtle, so breast cancer may be the first sign to appear. Inherited mutations in PTEN predispose to multiple other cancers that may appear with breast cancer in these patients. Also, this project demonstrated the value of patients with germline translocations and breast cancer for the identification of tumor suppressor genes
Conversations in genetics. an oral history of our intellectual heritage in genetics ( Visual )
1 edition published in 2005 in English and held by 3 WorldCat member libraries worldwide
Arno G. Motulsky talks to Mary-Claire King about his work on the genetics of human disease
Environmental and Lifestyle Influences on Breast Cancer Risk: Clues From Women with Inherited Mutations in BRCA1 and BRCA2 ( )
2 editions published between 1999 and 2001 in English and held by 2 WorldCat member libraries worldwide
Women with inherited mutations in BRCAl or BRCA2 have significantly elevated risks of breast cancer. However, not all women with inherited BRCAl or BRCA2 mutations develop breast or ovarian cancer, and among those who do, ages at cancer onset vary widely even within the same family. If a woman with a BRCAl or BRCA2 mutation remains free of breast cancer for many years, it is possible that her status is due to chance, to modifying genes segregating in some families, or to environmental factors that influence risk. In this project, we evaluate environmental and lifestyle factors that could influence the impact of mutations in BRCA I and BRCA2 on disease risk. It is possible that such co-factors identified among genetically predisposed women may be generalized to women who have not inherited predisposition to breast or ovarian cancer, because clinically and biologically, inherited cancer is virtually indistinguishable from its far more common, non-inherited counterpart
Novel Functional Screen for New Breast Cancer Genes ( )
2 editions published between 2004 and 2005 in English and held by 2 WorldCat member libraries worldwide
Genetic instability is a hallmark of tumor development. Mechanisms for maintenance of genomic stability are heterogeneous and identification of the genes responsible a critical goal of cancer biologists. The very large number of genetic alterations in breast tumors and genetic heterogeneity, even within a single breast tumor, strongly suggests that some mutator mechanism must be involved in breast tumorigenesis. Our hypothesis is that a mutator mechanism contributes to the development of breast cancer. However, since breast tumors do not display an obvious phenotype that signals the presence of a mutator defect (such as microsatellite instability), another scheme to identify defects in repair genes and their targets is necessary. Thus, our first objective is to use a novel yeast model system to identify genes that are previously unrecognized targets of mutator mechanisms and to determine whether these genes are altered in breast tumors. Our second objective is to identify genes that function as novel mutators in the yeast system then evaluate whether any are altered in breast tumors. The identification of mutator genes and their targets that contribute to the etiology of breast cancer will enhance our understanding of the genetic mechanisms involved in initiation and progress of disease. These genes will impact drug and biomarker discovery and ultimately, revolutionize patient care
Protein polymorphisms in chimpanzee and human evolution by Mary-Claire King ( Book )
1 edition published in 1973 in English and held by 2 WorldCat member libraries worldwide
Genetics of human breast cancer by Mary-Claire King ( Recording )
1 edition published in 1994 in English and held by 1 WorldCat member library worldwide
Novel Functional Screen for New Breast Cancer Genes ( )
1 edition published in 2003 in English and held by 1 WorldCat member library worldwide
All cells are subject to continual DNA damage. For this reason, elaborate pathways have been developed to monitor DNA damage and to coordinate cell cycle progression with DNA repair. To date, over 70 genes involved in DNA damage surveillance and repair have been identified (Wood, Mitchell et al. 2001). These genes include those involved in mismatch repair, homologous recombination, non-homologous end joining, and signaling cascades that respond to DNA damage. However, only a few of these genes have been shown to be associated with breast tumor development. The very large number of genetic alterations in breast tumors, and genetic heterogeneity even within a single breast tumor, strongly suggest that other repair genes must play a role in breast tumorigenesis
Genetics and molecular biology of breast cancer : Meeting on cancer cells : Abstracts and programme ( Book )
1 edition published in 1992 in English and held by 1 WorldCat member library worldwide
Formation of chimeric genes by copy number variation as a mutational mechanism in schizophrenia by Caitlin Fields Rippey ( )
1 edition published in 2013 in English and held by 1 WorldCat member library worldwide
Chimeric genes are caused by structural genomic rearrangements that fuse together portions of two different genes to create a novel gene. Chimeras may differ from their parent genes in localization, regulation, or function. We screened 122 individuals with schizophrenia and 120 controls for germline rearrangements anywhere in the genome leading to chimeras. Three cases and zero controls harbored such events: fusions of MATK to ZFR2, of DNAJA2 to NETO2, and of MAP3K3 to DDX42. Each fusion produces a stable protein when exogenously expressed in cultured cells. Temporal expression data indicate that the parent genes of all three chimeras are expressed in the brain during development. We detected the chimeric transcripts of DNAJA2-NETO2 and MAP3K3-DDX42 in patient lymphoblasts; parent genes of the MATK-ZFR2 chimera are expressed only in the brain. Formation of chimeras involved loss of critical domains of parent genes. Subcellular localizations of DNAJA2-NETO2 and MAP3K3-DDX42 are dramatically altered compared to their parent genes. The MATK-ZFR2 chimera includes a novel, frame-shifting splice variant of the previously uncharacterized ZFR2 gene. In contrast with the nuclear localization of full-length ZFR2, frameshifted ZFR2 localizes preferentially to dendritic branch sites, and its chimera is predicted to be highly overexpressed during development. Germline chimeric mutations in schizophrenia provide a new model for functional interpretation of structural variation in human illness, and implicate new genes and pathways in schizophrenia pathogenesis
The genetic mapping of human breast cancer ( Visual )
1 edition published in 1991 in English and held by 1 WorldCat member library worldwide
The top half of the poster is a graphic design in orange, gray, and purple. The date (Dec. 19, 1991), time, and location of the lecture are given as well as the affiliation of the speaker with the School of Public Health, University of California, Berkeley. Lectures scheduled from Sept. 19, 1991 through May 27, 1992 are also listed
Conversations in genetics ( Visual )
1 edition published in 2003 in English and held by 1 WorldCat member library worldwide
Recorded on February 28, 2003, at the University of Washington, Seattle, WA., Mary-Claire King, American Cancer Society Professor of Medicine and Genome Sciences at University of Washington talks to Arno G. Motulsky, Professor Emeritus of Medicine and Genome Sciences, University of Washington. Motulsky is a founding father of Medical Genetics and Pharmacogenetics. His innovative work in red cell genetics demonstrated the role of G6PD enzyme deficiency in protection against malaria, and the successful use of marrow transplantation in treatment ofhereditary red cell disease in outbred mice. His landmark studies on the association of lipid disorders with coronary heart disease with Joseph Goldstein, and on the detection of subtle variants having altered colour perception with Samir Deeb, created important paradigms for understanding the genetics of complex human traits. Motulsky's prescient establishment of one of the first academic units to train medical geneticists and co-authorship of now classic textbooks in human genetics, continue to have a majror impact on the field
Genomic analysis of breast and ovarian cancer ( Visual )
1 edition published in 2005 in English and held by 1 WorldCat member library worldwide
Mary Claire King ( Visual )
1 edition published in 1996 in English and held by 1 WorldCat member library worldwide
Host Marcia Alvar speaks with Mary-Claire King, Professor of Medicine and Genetics at the University of Washington, and a nationally known breast-cancer researcher. She is also known for her medical and political work in Chile, Argentina and El Salvador. In 1990, she demonstrated that a single gene is responsible for early-onset breast cancer
Gene(sis) contemporary art explores human genomics : public programs, April-May 2002 ( Visual )
1 edition published in 2002 in English and held by 1 WorldCat member library worldwide
Gene(sis): Contemporary Art Explores Human Genomics is a major traveling exhibition that showcases powerful new artwork created in direct response to recent developments in human genomics. This research is having an enormous impact on artistic practice, providing new tools, processes, materials, and issues for consideration. Organized by the Henry Art Gallery, Gene(sis) seeks to bridge art and science by elucidating technical advances for a lay audience and examining ethical issues raised by genomic research. Recognizing the complexity that these new opportunities present, curator Robin Held developed the exhibition during three years of on-going dialogue with geneticists, artists, science historians, medical ethicists, and art historians. In the spirit of fostering dialogue across disciplines, an extensive array of public programming is slated at each tour venue in conjunction with the exhibition. Gene(sis) seeks to encourage public discourse and deeper understanding of genomics and its potential impact on our everyday lives.--Exhibition Web site
 
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Audience Level
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  Kids General Special  
Audience level: 0.39 (from 0.00 for Environmen ... to 1.00 for Genetic Al ...)
Languages
English (41)