WorldCat Identities

King, Mary Claire

Overview
Works: 30 works in 54 publications in 1 language and 533 library holdings
Genres: History  Conference papers and proceedings  Nonfiction films  Interviews  Television interviews  Nonfiction television programs  Television series  Academic theses 
Roles: Author, Interviewee, Speaker
Classifications: RC280.B8, 616.9944906
Publication Timeline
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Most widely held works about Mary Claire King
 
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Most widely held works by Mary Claire King
The difference between us( Visual )

4 editions published between 2003 and 2007 in English and held by 68 WorldCat member libraries worldwide

A three part series exploring the history of race perceptions and behaviors towards races in the United States, within the context of recent scientific discoveries which have have toppled the concept of biological race. Episode one follows students who sequence and compare their own DNA looking for a "race marker." It also looks at the history of racism in the U.S., the advent of stereotypes based on physical attributes attributed to races and somatotypes with particular reference to African Americans
The difference between us( Visual )

2 editions published between 2003 and 2013 in English and held by 38 WorldCat member libraries worldwide

First in a three-part series exploring the history of race perceptions and behaviors towards races in the United States, within the context of recent scientific discoveries which have have toppled the concept of biological race. This segment follows a dozen students, including Black athletes and Asian American string players, who sequence and compare their own DNA looking for a "race marker." Also looks at the history of racism in the U.S., the advent of stereotypes based on physical attributes attributed to races and somatotypes with particular reference to African Americans
Abstracts of papers presented at the Cold Spring Harbor meeting on cancer cells : genetics and molecular biology of breast cancer, September 2-September 6, 1992 by Cold Spring Harbor, NY> Meeting on Cancer Cells Genetics and Molecular Biology of Breast Cancer. <1992( Book )

4 editions published in 1992 in English and held by 29 WorldCat member libraries worldwide

Abstracts of papers presented at the 2002 meeting on human origins & disease, October 30-November 3, 2002( Book )

1 edition published in 2002 in English and held by 16 WorldCat member libraries worldwide

Abstracts of papers presented at the 2008 meeting on personal genomes : October 9-October 12, 2008( Book )

1 edition published in 2008 in English and held by 11 WorldCat member libraries worldwide

Protein polymorphisms in chimpanzee and human evolution by Mary-Claire King( )

2 editions published in 1973 in English and held by 5 WorldCat member libraries worldwide

Conversations in genetics. an oral history of our intellectual heritage in genetics( Visual )

1 edition published in 2005 in English and held by 3 WorldCat member libraries worldwide

Arno G. Motulsky talks to Mary-Claire King about his work on the genetics of human disease
Environmental and Lifestyle Influences on Breast Cancer Risk: Clues From Women with Inherited Mutations in BRCA1 and BRCA2( Book )

6 editions published between 1999 and 2001 in English and held by 3 WorldCat member libraries worldwide

This project aims to identify potentially preventable environmental influences on breast and ovarian cancer by focusing on a population of women with genetically inherited predisposition to the disease. This is an extension of our ongoing research into the genetics of breast and ovarian cancer among Jewish women in the New York City area. The IDEA project centered on female relatives of breast cancer patients with confirmed mutations in BRCAl or BRCA2. Each relative provided a blood sample for mutation testing and completed an extensive questionnaire addressing epidemiologic factors in breast cancer risk. Among participants, inherited mutations in BRCAl and BRCA2 were more frequent in women with a younger breast cancer diagnosis and in women with a breast and/or ovarian cancer family history. Breast cancer risks increased over time among women with mutations, suggesting the influence of environmental factors. The experiences and exposures of women with mutations who did and did not develop breast or ovarian cancer were compared to identify factors that ameliorate or exacerbate risk in this high-risk group. These risk factors may be generalized to women without inherited vulnerability to breast or ovarian cancer, as inherited cancer is virtually indistinguishable, clinically and biologically, from its non inherited counterpart
Genetic Alterations in Familial Breast Cancer: Mapping and Cloning Genes Other Than BRCAl( Book )

4 editions published between 1996 and 1997 in English and held by 2 WorldCat member libraries worldwide

The purpose of this project was to identify genes responsible for inherited predisposition to breast cancer in families. The gene PTEN was successfully cloned by this project, and simultaneously by others (for a different reason) and proved to be such a gene. This project indicated that inherited mutations in PTEN predispose to breast cancer in women with the rare Cowden's syndrome. However, symptoms of that syndrome may be very subtle, so breast cancer may be the first sign to appear. Inherited mutations in PTEN predispose to multiple other cancers that may appear with breast cancer in these patients. Also, this project demonstrated the value of patients with germline translocations and breast cancer for the identification of tumor suppressor genes
Novel Functional Screen for New Breast Cancer Genes( Book )

4 editions published between 2003 and 2005 in English and held by 1 WorldCat member library worldwide

All cells are subject to continual DNA damage. For this reason, elaborate pathways have been developed to monitor DNA damage and to coordinate cell cycle progression with DNA repair. To date, over 70 genes involved in DNA damage surveillance and repair have been identified (Wood, Mitchell et al. 2001). These genes include those involved in mismatch repair, homologous recombination, non-homologous end joining, and signaling cascades that respond to DNA damage. However, only a few of these genes have been shown to be associated with breast tumor development. The very large number of genetic alterations in breast tumors, and genetic heterogeneity even within a single breast tumor, strongly suggest that other repair genes must play a role in breast tumorigenesis
Genomics of inherited bone marrow failure and myelodysplasia by Michael Yu Zhang( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Bone marrow failure and myelodysplastic syndromes (BMF/MDS) are disorders of impaired blood cell production with increased leukemia risk. BMF/MDS may be acquired or inherited, a distinction critical for treatment selection. Currently, diagnosis of these inherited syndromes is based on clinical history, family history, and laboratory studies, which directs the ordering of genetic tests on a gene-by-gene basis. However, despite extensive clinical workup and serial genetic testing, many cases remain unexplained. We sought to define the genetic etiology and pathophysiology of unclassified bone marrow failure and myelodysplastic syndromes. First, to determine the extent to which patients remained undiagnosed due to atypical or cryptic presentations of known inherited BMF/MDS, we developed a massively-parallel, next-generation DNA sequencing assay to simultaneously screen for mutations in 85 BMF/MDS genes. Querying 71 pediatric and adult patients with unclassified BMF/MDS using this assay revealed 8 (11%) patients with constitutional, pathogenic mutations in GATA2, RUNX1, DKC1, or LIG4. All eight patients lacked classic features or laboratory findings for their syndromes. These data suggest that the current clinical practice of directed testing of individual genes failed to diagnose patients with cryptic disease presentations and inform the integration of broad genetic screening into the diagnostic workup of BMF/MDS. In cases where broad screening of known genes failed to identify an inherited cause, we sought to discover new genes responsible for inherited BMF/MDS. We identified kindreds with unclassified disease presenting in multiple family members and sequenced the complete coding regions of their genomes (exome). In a family with low blood counts and malignancy, we discovered a novel germline heterozygous mutation in the transcription factor ETV6 segregating with the disease phenotype. The mutant protein is defective in transcriptional regulation, inhibits wild-type ETV6 in a dominant negative manner, and impairs hematopoiesis when expressed in human hematopoietic stem cells. Together, our studies provide new methodologies and genetic associations to enhance the diagnosis of inherited BMF/MDS
The genetic mapping of human breast cancer( Visual )

1 edition published in 1991 in English and held by 1 WorldCat member library worldwide

The top half of the poster is a graphic design in orange, gray, and purple. The date (Dec. 19, 1991), time, and location of the lecture are given as well as the affiliation of the speaker with the School of Public Health, University of California, Berkeley. Lectures scheduled from Sept. 19, 1991 through May 27, 1992 are also listed
Breast and ovarian cancer risks due inherited mutation in BRCA1 and BRCA2 by Mary-Claire King( )

1 edition published in 2003 in English and held by 1 WorldCat member library worldwide

Her-2 : the making of herceptin, a revolutionary treatment for breast cancer by Robert Bazell( Book )

1 edition published in 1998 in English and held by 1 WorldCat member library worldwide

Two years after she underwent a mastectomy and chemotherapy, Barbara Bradfield's aggressive breast cancer had recurred and spread to her lungs. The outlook was grim. Then she took part in Genentech's clinical trials for a new drug. Five years later she remains cancer free. This is the biography of Her-2, Herceptin, the drug that provoked dramatic responses in Barbara and other women in the trials that offers promise for hundreds of thousands of women
Mary Claire King( Visual )

1 edition published in 1996 in English and held by 1 WorldCat member library worldwide

Host Marcia Alvar speaks with Mary-Claire King, Professor of Medicine and Genetics at the University of Washington, and a nationally known breast-cancer researcher. She is also known for her medical and political work in Chile, Argentina and El Salvador. In 1990, she demonstrated that a single gene is responsible for early-onset breast cancer
Mapping human history by Mary-Claire King( )

1 edition published in 2002 in English and held by 1 WorldCat member library worldwide

Formation of chimeric genes by copy number variation as a mutational mechanism in schizophrenia by Caitlin Fields Rippey( )

1 edition published in 2013 in English and held by 1 WorldCat member library worldwide

Chimeric genes are caused by structural genomic rearrangements that fuse together portions of two different genes to create a novel gene. Chimeras may differ from their parent genes in localization, regulation, or function. We screened 122 individuals with schizophrenia and 120 controls for germline rearrangements anywhere in the genome leading to chimeras. Three cases and zero controls harbored such events: fusions of MATK to ZFR2, of DNAJA2 to NETO2, and of MAP3K3 to DDX42. Each fusion produces a stable protein when exogenously expressed in cultured cells. Temporal expression data indicate that the parent genes of all three chimeras are expressed in the brain during development. We detected the chimeric transcripts of DNAJA2-NETO2 and MAP3K3-DDX42 in patient lymphoblasts; parent genes of the MATK-ZFR2 chimera are expressed only in the brain. Formation of chimeras involved loss of critical domains of parent genes. Subcellular localizations of DNAJA2-NETO2 and MAP3K3-DDX42 are dramatically altered compared to their parent genes. The MATK-ZFR2 chimera includes a novel, frame-shifting splice variant of the previously uncharacterized ZFR2 gene. In contrast with the nuclear localization of full-length ZFR2, frameshifted ZFR2 localizes preferentially to dendritic branch sites, and its chimera is predicted to be highly overexpressed during development. Germline chimeric mutations in schizophrenia provide a new model for functional interpretation of structural variation in human illness, and implicate new genes and pathways in schizophrenia pathogenesis
Conversations in genetics( Visual )

1 edition published in 2003 in English and held by 1 WorldCat member library worldwide

Recorded on February 28, 2003, at the University of Washington, Seattle, WA., Mary-Claire King, American Cancer Society Professor of Medicine and Genome Sciences at University of Washington talks to Arno G. Motulsky, Professor Emeritus of Medicine and Genome Sciences, University of Washington. Motulsky is a founding father of Medical Genetics and Pharmacogenetics. His innovative work in red cell genetics demonstrated the role of G6PD enzyme deficiency in protection against malaria, and the successful use of marrow transplantation in treatment ofhereditary red cell disease in outbred mice. His landmark studies on the association of lipid disorders with coronary heart disease with Joseph Goldstein, and on the detection of subtle variants having altered colour perception with Samir Deeb, created important paradigms for understanding the genetics of complex human traits. Motulsky's prescient establishment of one of the first academic units to train medical geneticists and co-authorship of now classic textbooks in human genetics, continue to have a majror impact on the field
Genetics of human breast cancer by Mary-Claire King( Recording )

1 edition published in 1994 in English and held by 1 WorldCat member library worldwide

Genomic analysis of breast and ovarian cancer( Visual )

1 edition published in 2005 in English and held by 1 WorldCat member library worldwide

 
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Her-2 : the making of herceptin, a revolutionary treatment for breast cancer
Alternative Names
Mary-Claire King American geneticist

Mary-Claire King Amerikaans biologe

Mary-Claire King genetista statunitense

Mary-Claire King US-amerikanische Genetikerin

מארי-קלייר קינג

مری کلر کینگ

Languages
English (50)

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