WorldCat Identities

King, Mary Claire

Overview
Works: 27 works in 42 publications in 1 language and 529 library holdings
Genres: History  Conference proceedings  Interviews  Exhibition catalogs 
Roles: Author, Interviewee
Classifications: GN269, 305.800973
Publication Timeline
Key
Publications about  Mary Claire King Publications about Mary Claire King
Publications by  Mary Claire King Publications by Mary Claire King
Most widely held works about Mary Claire King
 
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Most widely held works by Mary Claire King
The difference between us ( Visual )
4 editions published between 2003 and 2007 in English and held by 80 WorldCat member libraries worldwide
A three part series exploring the history of race perceptions and behaviors towards races in the United States, within the context of recent scientific discoveries which have toppled the concept of biological race. Episode one follows students who sequence and compare their own DNA looking for a "race marker." It also looks at the history of racism in the U.S., the advent of stereotypes based on physical attributes attributed to races and somatotypes with particular reference to African Americans
The difference between us ( Visual )
2 editions published between 2003 and 2013 in English and held by 29 WorldCat member libraries worldwide
A three part series exploring the history of race perceptions and behaviors towards races in the United States, within the context of recent scientific discoveries which have have toppled the concept of biological race. Episode one follows students who sequence and compare their own DNA looking for a "race marker." It also looks at the history of racism in the U.S., the advent of stereotypes based on physical attributes attributed to races and somatotypes with particular reference to African Americans
Abstracts of papers presented at the Cold Spring Harbor meeting on cancer cells : genetics and molecular biology of breast cancer, September 2-September 6, 1992 by Cold Spring Harbor, NY> Meeting on Cancer Cells Genetics and Molecular Biology of Breast Cancer. <1992 ( Book )
2 editions published in 1992 in English and held by 26 WorldCat member libraries worldwide
Abstracts of papers presented at the 2002 meeting on human origins & disease, October 30-November 3, 2002 ( Book )
1 edition published in 2002 in English and held by 16 WorldCat member libraries worldwide
Abstracts of papers presented at the 2008 meeting on personal genomes: October 9-October 12, 2008 ( Book )
1 edition published in 2008 in English and held by 10 WorldCat member libraries worldwide
Genetic Alterations in Familial Breast Cancer: Mapping and Cloning Genes Other Than BRCAl ( )
4 editions published between 1995 and 1997 in English and held by 4 WorldCat member libraries worldwide
The purpose of this project is to identify genes responsible for inherited susceptibility to breast cancer in families. Two such genes have been cloned (BRCA1 and BRCA2), but the existence of families with many cases of breast cancer but no mutations in these genes suggests that other BRCA genes may exist. Using an integrated approach involving dissection of germline chromosomal rearrangements in women with very early onset breast cancer, coupled with linkage analysis in families, we are cloning the gene on chromosome 10q responsible for Cowden disease and possibly for breast cancer in the absence of other Cowden symptoms
Conversations in genetics. an oral history of our intellectual heritage in genetics ( Visual )
1 edition published in 2005 in English and held by 3 WorldCat member libraries worldwide
Arno G. Motulsky talks to Mary-Claire King about his work on the genetics of human disease
Environmental and Lifestyle Influences on Breast Cancer Risk: Clues From Women with Inherited Mutations in BRCA1 and BRCA2 ( )
2 editions published between 1999 and 2001 in English and held by 2 WorldCat member libraries worldwide
This project aims to identify potentially preventable environmental influences on breast and ovarian cancer by focusing on a population of women with genetically inherited predisposition to the disease. This is an extension of our ongoing research into the genetics of breast and ovarian cancer among Jewish women in the New York City area. The IDEA project centered on female relatives of breast cancer patients with confirmed mutations in BRCAl or BRCA2. Each relative provided a blood sample for mutation testing and completed an extensive questionnaire addressing epidemiologic factors in breast cancer risk. Among participants, inherited mutations in BRCAl and BRCA2 were more frequent in women with a younger breast cancer diagnosis and in women with a breast and/or ovarian cancer family history. Breast cancer risks increased over time among women with mutations, suggesting the influence of environmental factors. The experiences and exposures of women with mutations who did and did not develop breast or ovarian cancer were compared to identify factors that ameliorate or exacerbate risk in this high-risk group. These risk factors may be generalized to women without inherited vulnerability to breast or ovarian cancer, as inherited cancer is virtually indistinguishable, clinically and biologically, from its non inherited counterpart
Protein polymorphisms in chimpanzee and human evolution by Mary-Claire King ( Book )
1 edition published in 1973 in English and held by 2 WorldCat member libraries worldwide
Novel Functional Screen for New Breast Cancer Genes ( )
2 editions published between 2004 and 2005 in English and held by 2 WorldCat member libraries worldwide
Genetic instability is a hallmark of tumor development. Mechanisms for maintenance of genomic stability are heterogeneous and identification of the genes responsible a critical goal of cancer biologists. The very large number of genetic alterations in breast tumors and genetic heterogeneity, even within a single breast tumor, strongly suggests that some mutator mechanism must be involved in breast tumorigenesis. Our hypothesis is that a mutator mechanism contributes to the development of breast cancer. However, since breast tumors do not display an obvious phenotype that signals the presence of a mutator defect (such as microsatellite instability), another scheme to identify defects in repair genes and their targets is necessary. Thus, our first objective is to use a novel yeast model system to identify genes that are previously unrecognized targets of mutator mechanisms and to determine whether these genes are altered in breast tumors. Our second objective is to identify genes that function as novel mutators in the yeast system then evaluate whether any are altered in breast tumors. The identification of mutator genes and their targets that contribute to the etiology of breast cancer will enhance our understanding of the genetic mechanisms involved in initiation and progress of disease. These genes will impact drug and biomarker discovery and ultimately, revolutionize patient care
Formation of chimeric genes by copy number variation as a mutational mechanism in schizophrenia by Caitlin Fields Rippey ( )
1 edition published in 2013 in English and held by 1 WorldCat member library worldwide
Chimeric genes are caused by structural genomic rearrangements that fuse together portions of two different genes to create a novel gene. Chimeras may differ from their parent genes in localization, regulation, or function. We screened 122 individuals with schizophrenia and 120 controls for germline rearrangements anywhere in the genome leading to chimeras. Three cases and zero controls harbored such events: fusions of MATK to ZFR2, of DNAJA2 to NETO2, and of MAP3K3 to DDX42. Each fusion produces a stable protein when exogenously expressed in cultured cells. Temporal expression data indicate that the parent genes of all three chimeras are expressed in the brain during development. We detected the chimeric transcripts of DNAJA2-NETO2 and MAP3K3-DDX42 in patient lymphoblasts; parent genes of the MATK-ZFR2 chimera are expressed only in the brain. Formation of chimeras involved loss of critical domains of parent genes. Subcellular localizations of DNAJA2-NETO2 and MAP3K3-DDX42 are dramatically altered compared to their parent genes. The MATK-ZFR2 chimera includes a novel, frame-shifting splice variant of the previously uncharacterized ZFR2 gene. In contrast with the nuclear localization of full-length ZFR2, frameshifted ZFR2 localizes preferentially to dendritic branch sites, and its chimera is predicted to be highly overexpressed during development. Germline chimeric mutations in schizophrenia provide a new model for functional interpretation of structural variation in human illness, and implicate new genes and pathways in schizophrenia pathogenesis
The genetic mapping of human breast cancer ( Visual )
1 edition published in 1991 in English and held by 1 WorldCat member library worldwide
The top half of the poster is a graphic design in orange, gray, and purple. The date (Dec. 19, 1991), time, and location of the lecture are given as well as the affiliation of the speaker with the School of Public Health, University of California, Berkeley. Lectures scheduled from Sept. 19, 1991 through May 27, 1992 are also listed
Identifying new genes for inherited breast cancer by exome sequencing by Cailyn Helen Spurrell ( Book )
1 edition published in 2013 in English and held by 1 WorldCat member library worldwide
Breast cancer is the most common cancer among American women and family history is an important risk factor for its occurrence. More than 20 genes have been identified with inherited mutations that lead to significantly increased risk of breast cancer. However, most familial breast cancer is not explained by mutations in these genes. The goal of this project was to identify additional breast cancer genes by exome sequencing. In order to select families for gene discovery, we first screened families for mutations in all known breast cancer genes using targeted capture and massively parallel sequencing (BROCA). Families that remained unsolved after screening with BROCA were evaluated by exome sequencing. Germline DNA of 144 subjects with breast cancer from 54 high incidence families was sequenced. All truncating mutations shared by at least two affected persons in a family were genotyped in all participating members of that family in order to evaluate co-segregation with cancer. Rare truncating mutations co-segregating with breast and ovarian cancer were detected in ATR, CHEK1, and GEN1, each in one of the 54 families. ATR is recruited to sites of DNA damage; ATR phosphorylates CHEK1 in response to DNA damage, leading to a halt in cell cycle progression; GEN1 is an endonuclease that resolves Holliday junctions. Like BRCA1 and BRCA2, all three candidate genes function in biological pathways related to homologous recombination repair. In order to identify additional mutations in these three genes, unrelated women with breast cancer or ovarian cancer and controls were evaluated with high-throughput targeted sequencing approaches including BROCA custom capture and Molecular Inversion Probes (MIPs). Public databases were also reviewed. In ATR, truncating mutations were identified in 4 of 2544 cases and 3 of 7652 controls (P = 0.049). In CHEK1 truncating mutations were identified in 5 of 2544 cases and 1 of 7652 controls (P = 0.004). In GEN1, truncating mutations were identified in 2 of 1717 cases and 3 of 7652 controls (P = 0.21). This study suggests new candidate genes for inherited predisposition to breast cancer while also demonstrating the challenges facing gene discovery for this complex disease
Mary Claire King ( Visual )
1 edition published in 1996 in English and held by 1 WorldCat member library worldwide
Host Marcia Alvar speaks with Mary-Claire King, Professor of Medicine and Genetics at the University of Washington, and a nationally known breast-cancer researcher. She is also known for her medical and political work in Chile, Argentina and El Salvador. In 1990, she demonstrated that a single gene is responsible for early-onset breast cancer
Genomic analysis of breast and ovarian cancer ( Visual )
1 edition published in 2005 in English and held by 1 WorldCat member library worldwide
Conversations in genetics ( Visual )
1 edition published in 2003 in English and held by 1 WorldCat member library worldwide
Recorded on February 28, 2003, at the University of Washington, Seattle, WA., Mary-Claire King, American Cancer Society Professor of Medicine and Genome Sciences at University of Washington talks to Arno G. Motulsky, Professor Emeritus of Medicine and Genome Sciences, University of Washington. Motulsky is a founding father of Medical Genetics and Pharmacogenetics. His innovative work in red cell genetics demonstrated the role of G6PD enzyme deficiency in protection against malaria, and the successful use of marrow transplantation in treatment ofhereditary red cell disease in outbred mice. His landmark studies on the association of lipid disorders with coronary heart disease with Joseph Goldstein, and on the detection of subtle variants having altered colour perception with Samir Deeb, created important paradigms for understanding the genetics of complex human traits. Motulsky's prescient establishment of one of the first academic units to train medical geneticists and co-authorship of now classic textbooks in human genetics, continue to have a majror impact on the field
Novel Functional Screen for New Breast Cancer Genes ( )
1 edition published in 2003 in English and held by 1 WorldCat member library worldwide
All cells are subject to continual DNA damage. For this reason, elaborate pathways have been developed to monitor DNA damage and to coordinate cell cycle progression with DNA repair. To date, over 70 genes involved in DNA damage surveillance and repair have been identified (Wood, Mitchell et al. 2001). These genes include those involved in mismatch repair, homologous recombination, non-homologous end joining, and signaling cascades that respond to DNA damage. However, only a few of these genes have been shown to be associated with breast tumor development. The very large number of genetic alterations in breast tumors, and genetic heterogeneity even within a single breast tumor, strongly suggest that other repair genes must play a role in breast tumorigenesis
Gene(sis) contemporary art explores human genomics : public programs, April-May 2002 ( Visual )
1 edition published in 2002 in English and held by 1 WorldCat member library worldwide
Gene(sis): Contemporary Art Explores Human Genomics is a major traveling exhibition that showcases powerful new artwork created in direct response to recent developments in human genomics. This research is having an enormous impact on artistic practice, providing new tools, processes, materials, and issues for consideration. Organized by the Henry Art Gallery, Gene(sis) seeks to bridge art and science by elucidating technical advances for a lay audience and examining ethical issues raised by genomic research. Recognizing the complexity that these new opportunities present, curator Robin Held developed the exhibition during three years of on-going dialogue with geneticists, artists, science historians, medical ethicists, and art historians. In the spirit of fostering dialogue across disciplines, an extensive array of public programming is slated at each tour venue in conjunction with the exhibition. Gene(sis) seeks to encourage public discourse and deeper understanding of genomics and its potential impact on our everyday lives.--Exhibition Web site
Genetics of human breast cancer by Mary-Claire King ( Recording )
1 edition published in 1994 in English and held by 1 WorldCat member library worldwide
 
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Audience level: 0.39 (from 0.00 for Environmen ... to 1.00 for Genetic Al ...)
Languages
English (41)