WorldCat Identities

King, Mary Claire

Publication Timeline
.
Most widely held works about Mary Claire King
 
moreShow More Titles
fewerShow Fewer Titles
Most widely held works by Mary Claire King
The difference between us( Visual )

4 editions published between 2003 and 2007 in English and held by 63 WorldCat member libraries worldwide

A three part series exploring the history of race perceptions and behaviors towards races in the United States, within the context of recent scientific discoveries which have toppled the concept of biological race. Episode one follows students who sequence and compare their own DNA looking for a "race marker." It also looks at the history of racism in the U.S., the advent of stereotypes based on physical attributes attributed to races and somatotypes with particular reference to African Americans
The difference between us( Visual )

2 editions published between 2003 and 2013 in English and held by 39 WorldCat member libraries worldwide

A three part series exploring the history of race perceptions and behaviors towards races in the United States, within the context of recent scientific discoveries which have have toppled the concept of biological race. Episode one follows students who sequence and compare their own DNA looking for a "race marker." It also looks at the history of racism in the U.S., the advent of stereotypes based on physical attributes attributed to races and somatotypes with particular reference to African Americans
Abstracts of papers presented at the Cold Spring Harbor meeting on cancer cells : genetics and molecular biology of breast cancer, September 2-September 6, 1992 by Cold Spring Harbor, NY> Meeting on Cancer Cells Genetics and Molecular Biology of Breast Cancer. <1992( Book )

4 editions published in 1992 in English and held by 28 WorldCat member libraries worldwide

Abstracts of papers presented at the 2002 meeting on human origins & disease, October 30-November 3, 2002( Book )

1 edition published in 2002 in English and held by 16 WorldCat member libraries worldwide

Abstracts of papers presented at the 2008 meeting on personal genomes : October 9-October 12, 2008( Book )

1 edition published in 2008 in English and held by 11 WorldCat member libraries worldwide

Novel Functional Screen for New Breast Cancer Genes( Book )

6 editions published between 2003 and 2005 in English and held by 6 WorldCat member libraries worldwide

Genetic instability is a hallmark of tumor development. Mechanisms for maintenance of genomic stability are heterogeneous and identification of the genes responsible a critical goal of cancer biologists. The very large number of genetic alterations in breast tumors and genetic heterogeneity, even within a single breast tumor, strongly suggests that some mutator mechanism must be involved in breast tumorigenesis. Our hypothesis is that a mutator mechanism contributes to the development of breast cancer. However, since breast tumors do not display an obvious phenotype that signals the presence of a mutator defect (such as microsatellite instability), another scheme to identify defects in repair genes and their targets is necessary. Thus, our first objective is to use a novel yeast model system to identify genes that are previously unrecognized targets of mutator mechanisms and to determine whether these genes are altered in breast tumors. Our second objective is to identify genes that function as novel mutators in the yeast system then evaluate whether any are altered in breast tumors. The identification of mutator genes and their targets that contribute to the etiology of breast cancer will enhance our understanding of the genetic mechanisms involved in initiation and progress of disease. These genes will impact drug and biomarker discovery and ultimately, revolutionize patient care
Environmental and Lifestyle Influences on Breast Cancer Risk: Clues from Women with Inherited Mutations in BRCA1 and BRCA2( Book )

6 editions published between 1999 and 2001 in English and held by 6 WorldCat member libraries worldwide

This project aims to identify potentially preventable environmental influences on breast and ovarian cancer by focusing on a population of women with genetically inherited predisposition to the disease. This study is an extension of our ongoing research into the genetics of breast and ovarian cancer among women of Jewish ancestry in the New York City area. The IDEA project focuses on female relatives of breast cancer patients with confirmed mutations in BRCA 1 or BRCA2. Each relative provides a blood sample for mutation testing and completes an extensive questionnaire addressing epidemiologic factors in breast cancer risk. Not all women with inherited BRCA mutations develop breast or ovarian cancer, and among those who do, ages at cancer onset vary widely, even in families. As such, comparing the experiences and exposures of women with mutations who develop breast or ovarian cancer vs. women with the same mutations who remain cancer-free may identify factors that ameliorate or exacerbate risk in this group of very high-risk women. Risk factors identified among genetically predisposed women also may be generalized to women without inherited vulnerability to breast or ovarian cancer, since inherited cancer is virtually indistinguishable, clinically and biologically, from its noninherited counterpart
Protein polymorphisms in chimpanzee and human evolution by Mary-Claire King( )

2 editions published in 1973 in English and held by 5 WorldCat member libraries worldwide

Conversations in genetics. an oral history of our intellectual heritage in genetics( Visual )

2 editions published between 2003 and 2005 in English and held by 4 WorldCat member libraries worldwide

Arno G. Motulsky talks to Mary-Claire King about his work on the genetics of human disease
Genetic Alterations in Familial Breast Cancer: Mapping and Cloning Genes Other than BRCA1( Book )

4 editions published between 1996 and 1997 in English and held by 4 WorldCat member libraries worldwide

The purpose of this project was to identify genes responsible for inherited predisposition to breast cancer in families. The gene PTEN was successfully cloned by this project, and simultaneously by others (for a different reason) and proved to be such a gene. This project indicated that inherited mutations in PTEN predispose to breast cancer in women with the rare Cowden's syndrome. However, symptoms of that syndrome may be very subtle, so breast cancer may be the first sign to appear. Inherited mutations in PTEN predispose to multiple other cancers that may appear with breast cancer in these patients. Also, this project demonstrated the value of patients with germline translocations and breast cancer for the identification of tumor suppressor genes
Genetic Alterations in Familial Breast Cancer: Mapping and Cloning Genes Other Than BRCAl( )

3 editions published between 1995 and 1998 in English and held by 3 WorldCat member libraries worldwide

The purpose of this project was to identify genes responsible for inherited predisposition to Breast cancer in families. The gene PTEN was successfully cloned by this project, and simultaneously by others (for a different reason) and proved to be such a gene. This project indicated that inherited mutations in PTEN predispose to breast cancer in women with the rare Cowden's syndrome. However, symptoms of that syndrome may be very subtle, so breast cancer may be the first sign to appear. Inherited mutations in PTEN predispose to multiple other cancers that may appear with breast cancer in these patients. Also, this project demonstrated the value of patients with germline translocations and breast cancer for the identification of tumor suppressor genes
Her-2 : the making of herceptin, a revolutionary treatment for breast cancer by Robert Bazell( Book )

2 editions published in 1998 in English and held by 3 WorldCat member libraries worldwide

Two years after she underwent a mastectomy and chemotherapy, Barbara Bradfield's aggressive breast cancer had recurred and spread to her lungs. The outlook was grim. Then she took part in Genentech's clinical trials for a new drug. Five years later she remains cancer free. This is the biography of Her-2, Herceptin, the drug that provoked dramatic responses in Barbara and other women in the trials that offers promise for hundreds of thousands of women
Psychiatric epidemiology : searching for the causes of mental disorders by Evelyn J Bromet( Book )

1 edition published in 2006 in English and held by 2 WorldCat member libraries worldwide

"Searching for the causes of mental disorders is as exciting as it is complex. The relationship between pathophysiology and its overt manifestations is exceedingly intricate, and often the causes of a disorder are elusive at best. This book is an invaluable resource for anyone trying to track these causes, whether they be clinical researchers, public health practitioners, or psychiatric epidemiologists-in-training. Uniting theory and practice in very clear language, it makes a wonderful contribution to both epidemiologic and psychiatric research. Rather than attempting to review the descriptive epidemiology of mental disorders, this book gives a much more dynamic exposition of the thinking and techniques used to establish it." "Starting out by tracing the brief history of psychiatric epidemiology, the book describes the study of risk factors as causes of mental disorders. Subsequent sections discuss approaches to investigation of biologic, genetic, and social causes and the statistical analysis of study results. The book concludes by following some of the problems involved in the search for genetic causes of mental disorders, and more complex causal relationships."--Résumé de l'éditeur
Gene(sis) : contemporary art explores human genomics : public programs, April-May 2002( Visual )

1 edition published in 2002 in English and held by 1 WorldCat member library worldwide

Gene(sis): Contemporary Art Explores Human Genomics is a major traveling exhibition that showcases powerful new artwork created in direct response to recent developments in human genomics. This research is having an enormous impact on artistic practice, providing new tools, processes, materials, and issues for consideration. Organized by the Henry Art Gallery, Gene(sis) seeks to bridge art and science by elucidating technical advances for a lay audience and examining ethical issues raised by genomic research. Recognizing the complexity that these new opportunities present, curator Robin Held developed the exhibition during three years of on-going dialogue with geneticists, artists, science historians, medical ethicists, and art historians. In the spirit of fostering dialogue across disciplines, an extensive array of public programming is slated at each tour venue in conjunction with the exhibition. Gene(sis) seeks to encourage public discourse and deeper understanding of genomics and its potential impact on our everyday lives.--Exhibition Web site
Mary Claire King( Visual )

1 edition published in 1996 in English and held by 1 WorldCat member library worldwide

Host Marcia Alvar speaks with Mary-Claire King, Professor of Medicine and Genetics at the University of Washington, and a nationally known breast-cancer researcher. She is also known for her medical and political work in Chile, Argentina and El Salvador. In 1990, she demonstrated that a single gene is responsible for early-onset breast cancer
Genomics of inherited bone marrow failure and myelodysplasia by Michael Yu Zhang( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Bone marrow failure and myelodysplastic syndromes (BMF/MDS) are disorders of impaired blood cell production with increased leukemia risk. BMF/MDS may be acquired or inherited, a distinction critical for treatment selection. Currently, diagnosis of these inherited syndromes is based on clinical history, family history, and laboratory studies, which directs the ordering of genetic tests on a gene-by-gene basis. However, despite extensive clinical workup and serial genetic testing, many cases remain unexplained. We sought to define the genetic etiology and pathophysiology of unclassified bone marrow failure and myelodysplastic syndromes. First, to determine the extent to which patients remained undiagnosed due to atypical or cryptic presentations of known inherited BMF/MDS, we developed a massively-parallel, next-generation DNA sequencing assay to simultaneously screen for mutations in 85 BMF/MDS genes. Querying 71 pediatric and adult patients with unclassified BMF/MDS using this assay revealed 8 (11%) patients with constitutional, pathogenic mutations in GATA2, RUNX1, DKC1, or LIG4. All eight patients lacked classic features or laboratory findings for their syndromes. These data suggest that the current clinical practice of directed testing of individual genes failed to diagnose patients with cryptic disease presentations and inform the integration of broad genetic screening into the diagnostic workup of BMF/MDS. In cases where broad screening of known genes failed to identify an inherited cause, we sought to discover new genes responsible for inherited BMF/MDS. We identified kindreds with unclassified disease presenting in multiple family members and sequenced the complete coding regions of their genomes (exome). In a family with low blood counts and malignancy, we discovered a novel germline heterozygous mutation in the transcription factor ETV6 segregating with the disease phenotype. The mutant protein is defective in transcriptional regulation, inhibits wild-type ETV6 in a dominant negative manner, and impairs hematopoiesis when expressed in human hematopoietic stem cells. Together, our studies provide new methodologies and genetic associations to enhance the diagnosis of inherited BMF/MDS
The genetic mapping of human breast cancer( Visual )

1 edition published in 1991 in English and held by 1 WorldCat member library worldwide

The top half of the poster is a graphic design in orange, gray, and purple. The date (Dec. 19, 1991), time, and location of the lecture are given as well as the affiliation of the speaker with the School of Public Health, University of California, Berkeley. Lectures scheduled from Sept. 19, 1991 through May 27, 1992 are also listed
Genomic analysis of breast and ovarian cancer( Visual )

1 edition published in 2005 in English and held by 1 WorldCat member library worldwide

Genetics of human breast cancer by Mary-Claire King( Recording )

1 edition published in 1994 in English and held by 1 WorldCat member library worldwide

Formation of chimeric genes by copy number variation as a mutational mechanism in schizophrenia by Caitlin Fields Rippey( )

1 edition published in 2013 in English and held by 1 WorldCat member library worldwide

Chimeric genes are caused by structural genomic rearrangements that fuse together portions of two different genes to create a novel gene. Chimeras may differ from their parent genes in localization, regulation, or function. We screened 122 individuals with schizophrenia and 120 controls for germline rearrangements anywhere in the genome leading to chimeras. Three cases and zero controls harbored such events: fusions of MATK to ZFR2, of DNAJA2 to NETO2, and of MAP3K3 to DDX42. Each fusion produces a stable protein when exogenously expressed in cultured cells. Temporal expression data indicate that the parent genes of all three chimeras are expressed in the brain during development. We detected the chimeric transcripts of DNAJA2-NETO2 and MAP3K3-DDX42 in patient lymphoblasts; parent genes of the MATK-ZFR2 chimera are expressed only in the brain. Formation of chimeras involved loss of critical domains of parent genes. Subcellular localizations of DNAJA2-NETO2 and MAP3K3-DDX42 are dramatically altered compared to their parent genes. The MATK-ZFR2 chimera includes a novel, frame-shifting splice variant of the previously uncharacterized ZFR2 gene. In contrast with the nuclear localization of full-length ZFR2, frameshifted ZFR2 localizes preferentially to dendritic branch sites, and its chimera is predicted to be highly overexpressed during development. Germline chimeric mutations in schizophrenia provide a new model for functional interpretation of structural variation in human illness, and implicate new genes and pathways in schizophrenia pathogenesis
 
moreShow More Titles
fewerShow Fewer Titles
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.33 (from 0.17 for DNA / ... to 0.96 for Genetic Al ...)

Her-2 : the making of herceptin, a revolutionary treatment for breast cancer
Covers
Psychiatric epidemiology : searching for the causes of mental disorders
Alternative Names
Mary-Claire King ahli biologi asal Amerika Serikat

Mary-Claire King Amerikaans biologe

Mary-Claire King genetista statunitense

Mary-Claire King US-amerikanische Genetikerin

Мері-Клер Кінг

Мэри Кинг

מארי-קלייר קינג

ماري كينغ

مری کلر کینق

مری کلر کینگ

瑪莉-克萊爾·金

Languages
English (60)