WorldCat Identities

Benzer, Seymour

Overview
Works: 35 works in 51 publications in 5 languages and 3,195 library holdings
Genres: Interviews  History  Biography 
Roles: Thesis advisor, Honoree
Classifications: QL537.D76, 610.62
Publication Timeline
Key
Publications about  Seymour Benzer Publications about Seymour Benzer
Publications by  Seymour Benzer Publications by Seymour Benzer
posthumous Publications by Seymour Benzer, published posthumously.
Most widely held works by Seymour Benzer
Conversations in genetics. an oral history of our intellectual heritage in genetics ( Visual )
in English and held by 25 WorldCat member libraries worldwide
A collection of conversations with geneticists who have made major contributions to the conceptual foundations of modern genetics. Accomplished researchers reflect on their research achievements and describe the paths they took during various phases of their lives. Useful to those interested in the history of genetics and the evolution of scientific ideas
The history of neuroscience in autobiography ( Visual )
1 edition published in 2006 in English and held by 5 WorldCat member libraries worldwide
One of a series of archival interviews from the Society for Neuroscience featuring pinoeering neuroscientists. This segment focuses on Seymour Benzer and Horace Barlow
The fine structure of the gene by Seymour Benzer ( Book )
1 edition published in 1962 in English and held by 4 WorldCat member libraries worldwide
The Harvey lectures; delivered under the auspices of the Harvey society of New York, 1960-1961 by Seymour Benzer ( Book )
1 edition published in 1961 in English and held by 3 WorldCat member libraries worldwide
Conversations in Genetics an oral history of our intellectual heritage in genetics. Vol. 2. ( Visual )
1 edition published in 2004 in English and held by 2 WorldCat member libraries worldwide
A collection of conversations with geneticists who have made major contributions to the conceptual foundations of modern genetics. Accomplished researchers reflect on their research achievements and describe the paths they took during various phases of their lives. Useful to those interested in the history of genetics and the evolution of scientific ideas
Neurogenetics of drosophila by Alberto Ferrús ( Book )
2 editions published in 1992 in English and held by 2 WorldCat member libraries worldwide
Drosophila feeding behavior and demographic mechanisms of lifespan extension by Gil B Carvalho ( )
2 editions published in 2010 in English and held by 2 WorldCat member libraries worldwide
"Why do we age? Most organisms undergo senescence, a process involving progressive functional decline culminating in death, yet this widespread phenomenon remains largely mysterious. A number of genetic and environmental factors affect longevity, the best conserved and most widely studied of which is dietary restriction (DR), a reduction of nutrient intake short of malnutrition. Since nutrient ingestion determines lifespan, any factor affecting longevity - particular food components, genetic pathways or drugs - may do so indirectly, by altering feeding behavior. This is particularly true in Drosophila, which is normally kept in conditions where food is present in excess. Moreover, since DR is applied by aging flies on two different food concentrations - diluted media are associated with an extended lifespan - animals may alter their intake in response to the change in nutrient content. Since the medium is also the only water source, this compensatory feeding would result in changes in hydration, introducing a second experimental variable. Despite these issues, Drosophila feeding behavior has classically been ignored or superficially characterized in the context of aging research, partly due to the absence of appropriate methodology. We developed two complementary assays allowing long-term measurement of food intake. Using these techniques, we present the first characterization of real-time Drosophila feeding behavior. Our results reveal gender-specific feeding trends and show that mating stimulates female appetite via the seminal Sex Peptide. Additionally, we show that ingestion is dramatically affected by food dilution or dietary additives. Animals fed concentrated media restrict their intake and are chronically thirsty. We have found that lifespan extension by classical DR paradigms is abolished in the presence of ad libitum water, challenging the long-held assumption that DR affects longevity by altering nutrient intake. We characterize a new regime that robustly prolongs lifespan irrespective of water availability, and thus likely represents a more relevant model for mammalian DR. In contrast to previous claims, demographic analysis using this paradigm indicates that DR acts not by reducing the immediate risk of death, but by slowing the accumulation of age-related damage. Our findings directly challenge current views on the mechanistic basis of DR and have broad implications for the study of aging and nutrition in model organisms."
Role of Apolipoprotein D and its homologs, in normal and pathological aging, in Drosophila melanogaster by Julien A Muffat ( )
2 editions published in 2009 in English and held by 2 WorldCat member libraries worldwide
"The free radical theory of aging is probably the most enduring one to date. It stipulates that, in the process of normal cellular function, in particular due to oxygen-based respiration, reactive oxygen species are formed. These constantly put a strain on the cell, damaging lipids in the membranes, causing protein aggregation and loss-of-function, or mutations in the genome. Over time, this accumulated damage overcomes the repair potential of a given cell, and scaled up to an entire organism, results in the deterioration seen in normal aging. Under these assumptions, age-related pathologies are only an acceleration of the process in a given tissue, leading to the emergence of the pathology over the noise of normal aging. In the past decade, invertebrates such as Drosophila melanogaster and C. elegans have provided invaluable insight into these processes and the canonical pathways that regulate them. This success is owed in part to the power of the genetic tools available, to their relatively short lifespans, and to the wide arrays of phenotypes that can be studied. We set out to study a particular protein, Glaz, whose overexpression enables fruitflies to live 30% longer than normal. This protein was identified as a hit from a screen looking at an accelerated aging paradigm, placing fruitflies in 100% oxygen. While an interesting protein in its own right, it was through its homology with mammalian Apolipoprotein D (ApoD), that our interest was truly piqued. ApoD and its homologs turn out to be fascinating proteins, upregulated by various stresses and in age-related diseases such as cancers and Alzheimer's. We showed, in our model organism of choice, that this upregulation is part of a beneficial stress response. Understanding and harnessing its functions can only help provide therapeutic approaches for a wide range of disorders."
Seymour Benzer Horace Barlow by H. B Barlow ( Visual )
1 edition published in 2005 in English and held by 2 WorldCat member libraries worldwide
One of a series of archival interviews from the Society for Neuroscience featuring pioneering neuroscientists. This segment focuses on Seymour Benzer and Horace Barlow
A Change From Nonsense to Sense in Genetic Code, By Seymour Benzer and Sewell P. Champe by Seymour Benzer ( Book )
1 edition published in 1962 in English and held by 1 WorldCat member library worldwide
Three varieties of human hæmoglobin D by Seymour Benzer ( Book )
1 edition published in 1958 in English and held by 1 WorldCat member library worldwide
Translational control mediates lifespan extension due to dietary restriction in Drosophila by Brian M Zid ( Book )
1 edition published in 2008 in English and held by 1 WorldCat member library worldwide
Genetic dissection of behavior by Seymour Benzer ( Book )
1 edition published in 1973 in English and held by 1 WorldCat member library worldwide
The Harvey lectures. Series 56 : 1960-1961 by Seymour Benzer ( Book )
1 edition published in 1961 in English and held by 1 WorldCat member library worldwide
Conversations in genetics ( Visual )
1 edition published in 2001 in English and held by 1 WorldCat member library worldwide
Recorded on November 9, 2001, in the Kerckhoff Library at the California Institute of Technology, Pasadena, CA., David Anderson, Roger W. Sperry Professor of Biology and Investigator, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA., talks to Seymour Benzer, James G. Boswell Professor of Neuroscience, Emeritus (Active), California Institute of Technology. Benzer's experiments in genetics have had extraordinarily far-reaching consequences in modern biology. His groudbreaking studies on fine structure mapping of the T4 rII locus defined the concept of the gene for the first tim in terms that could be related to DNA, and led the way to understanding the genetic code, gene organisation and regulation. His prescient work on behavioural genetics in flies opened the new field of neurogenetics. The discovery of genes governing circadian rhythms, chemo- and phototaxis, courtship, and learning and memory demonstrated the feasibility of direct systematic investigation of the genetic control of behaviour by mutational analysis. Benzer is an icon in genetics. Rarely has a scientific investigator made contributions that have impacted diverse areas so dramatically. He has received numerous awards for his work including the Lasker Award, the Wolf Prize, the Bower Award, and the Crafoord Prize
Identification and isolation of genes that code for formamidine receptors and formamidine sensitivity in Drosophila : Final report, Project no. I-884-85 by United States-Israel Binational Agricultural Research and Development Fund ( Book )
1 edition published in 1990 in English and held by 1 WorldCat member library worldwide
Oral history interview with Seymour Benzer by Seymour Benzer ( )
1 edition published in 1983 in English and held by 1 WorldCat member library worldwide
Mainly a discussion of Benzer's years at Purdue University during World War II and his transition from physics to biology. Major topics include his educational background; his work during the war on high back voltage diodes; his relationship with Karl Lark-Horovitz; his decision to work in biology and his first few years as a biologist
Photoelectric effects in germanium : contractor's report by Seymour Benzer ( Book )
1 edition published in 1945 in English and held by 1 WorldCat member library worldwide
Identification and isolation of genes that code for formamidine receptors and formamidine sensitivity in Drosophila by Yadin Dudai ( Book )
1 edition published in 1990 in English and held by 1 WorldCat member library worldwide
Talking with Seymour Benzer ( Visual )
1 edition published in 2001 in English and held by 1 WorldCat member library worldwide
Seymour Benzer évoque avec David Anderson ses travaux sur la structure du gène du phage, le code génétique et la génétique du comportement chez la Drosophile
 
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Languages
English (42)
Japanese (2)
Chinese (1)
Swedish (1)
German (1)
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