WorldCat Identities

Lauterbur, Paul C. 1929-2007

Overview
Works: 17 works in 31 publications in 2 languages and 607 library holdings
Genres: Conference proceedings 
Classifications: RC78.7.N83, 616.07548
Publication Timeline
Key
Publications about  Paul C Lauterbur Publications about Paul C Lauterbur
Publications by  Paul C Lauterbur Publications by Paul C Lauterbur
posthumous Publications by Paul C Lauterbur, published posthumously.
Most widely held works about Paul C Lauterbur
 
Most widely held works by Paul C Lauterbur
Principles of magnetic resonance imaging : a signal processing perspective by Zhi-Pei Liang ( Book )
14 editions published between 1999 and 2000 in English and held by 527 WorldCat member libraries worldwide
Development of Efficient Dynamic Magnetic Resonance Imaging Methods with Application to Breast Cancer Detection and Diagnosis ( )
2 editions published between 1996 and 1997 in English and held by 2 WorldCat member libraries worldwide
The goal of this predoctoral fellowship research project is to improve the temporal and spatial resolutions in dynamic contrast-enhanced magnetic resonance imaging of the breast by optimizing the Reduced-encoding Imaging by Generalized-series Reconstruction (RIGR) method. Specifically, we investigated the use of non-Fourier encoding for collecting the reduced encoding dynamic data sets. The conclusion from our study was that the current SVD encoding method biases the results towards reproducing the known features in the reference image and, therefore, is not appropriate for dynamic imaging applications. For that reason, we continue to acquire the dynamic data using Fourier encoding. Next, we incorporated dynamic information into the basis functions of the generalized-series model used by the RIGR algorithm. The TRIGR method resulted from incorporating information about the dynamic changes into the basis functions. Explicit edge constraints derived from the reference image were then used along with the contrast information from the dynamic data to inject dynamic information into the basis functions for both RIGR and TRIGR. Of these, the TRIGR method works better for contrast-enhanced imaging because the active reference image can be used for the edge extraction step
The design, syntheses, and physico-chemical studies of MRI contrast agents by Alan Kazunari Marumoto ( )
1 edition published in 1994 in English and held by 1 WorldCat member library worldwide
Magnetic Resonance Imaging (MRI) is a popular and powerful clinical diagnostic tool. The development of MRI contrast agents allows for even greater diagnostic ability. This thesis will address the design, syntheses and physico-chemical studies of two specific classes of MRI contrast agents: the DTPA bisamide macrocycles and the bile salt-like hepatobiliary targeted contrast agents. The DTPA bisamide macrocycles are synthesized from the condensation product of DTPA biscyclic-dianhydride with an appropriate 1,N-diaminoalkane. Physical properties such as metal binding and albumin binding as well as imaging studies, demonstrated that small DTPA bisamide macrocycles (15-18 member macrocycles) do not bind Gd(3+) as strongly as the linear DTPA derivatives. In addition, imaging studies demonstrated breast tumor and kidney enhancement. Nuclear Magnetic Resonance Dispersions (NMRD) were measured in hypotonic, isotonic, and hypertonic solutions with and without albumin present. The results of the NMRD coupled with the albumin binding studies indicate that the albumin associated Gd(3+)-complexes have higher relaxivity than the unbound Gd(3+) monochelates. This property appears to be weakly correlated with the lipophilicity of the chelates. The second class of contrast agents attempts to exploit the anion uptake receptors in the liver as a means of targeting agents to the liver and biliary tract. These compounds are synthesized from cholic acid derivatives. The cholic acid derivatives are modified to have a free primary amine. A DTPA chelate is attached to the free amide via an amide bond to form the bile-salt like contrast agents. MR imaging with these agents demonstrated liver enhancement in rats
Magnetic resonance diffusion imaging and spectral localization--new methods and their quantitative applications by Yihong Yang ( )
1 edition published in 1995 in English and held by 1 WorldCat member library worldwide
There has been a growing interest, in recent years, in the measurement of diffusion of water and metabolites in living systems by magnetic resonance (MR) techniques. Knowledge of the diffusion coefficients of the molecules can yield unique information about microstructure and function of tissue. We have developed a method for the measurement of anisotropic diffusion by MR projection reconstruction imaging, which is inherently insensitive to motion artifacts and can have higher signal-to-noise ratio compared with conventional Fourier transform imaging. Anisotropic diffusion of water in skeletal and smooth muscle has been investigated using this method. In addition, the water diffusion coefficient in rat uterus has been correlated to the hormonal level, which suggests that diffusion measurements on the human uterus may be useful in detecting endometrial pathology. We have also developed a method for localized diffusion measurement with efficient acquisition in arbitrarily-shaped regions. Experiments on phantoms and biological tissues have been performed using this method. The SLIM (spectral localization by imaging) technique was developed in this group in collaboration with a group at the University of Chicago. This technique has many advantages over the existing spectral localization techniques for in vivo studies. We have applied this technique to the quantitative analysis of regional phosphorus metabolite levels on human brain. The concentrations of the phosphorus metabolites have been measured in regions of human brain, such as cerebrum, cerebellum plus brain stem, and white and grey matter. In order to investigate the reliability of the SLIM technique in in vivo applications, we have developed a Bloch equation-based simulation method to carry out analyses on the combined effects of unavoidable experimental non-idealities and compartmental heterogeneity. For quantitative analysis in surface coil experiments, we have developed an optimized method for flip angle mapping by multiple echo imaging. The flip angle profile obtained from this method was used for compensation of signal intensity variations caused by the inhomogeneous B$sb1$ field. Finally, we have developed a method to measure spatially localized 2D correlation spectroscopy (SLIM COSY), which could provide localized in vivo COSY spectra in regions of interest
Nossa Capa= Our Magazine Cover by Paul C Lauterbur ( )
1 edition published in 2004 in English and held by 1 WorldCat member library worldwide
Applications of slim (spectral localization by imaging) localization technique by Haak Il Lee ( )
1 edition published in 1990 in English and held by 1 WorldCat member library worldwide
Because of the intrinsic inhomogeneity in the composition of living systems, applications of nuclear magnetic resonance spectroscopy (MRS) to the biological system require techniques that can discriminate signals according to their spatial origins and detect signals only from the operator-designated regions. These techniques are called localization techniques. Many techniques have been proposed for the localization of signals and some of them have been widely accepted for clinical applications. The ideal localization technique can be characterized as one which can provide spectrum (or spectra) simultaneously from any arbitrarily-shaped region (or regions) of interest in 2 or 3 spatial dimensions within a reasonable amount of experimental time. All the localization techniques that have been suggested so far are quite limited in their abilities compared to the requirements in the above ideal conditions. The Spectral Localization by IMaging (SLIM) technique that has been recently developed by this research group in collaboration with a group at the Univ. of Chicago has proved to very effective in obtaining localized spectra from regions of interest of any shape within a short time compared with other methods. This SLIM technique was first described for the proton spectroscopy of water and fat in 2D slices. We have made SLIM a more useful localization technique by showing it has many applications including (a) 4D $sp{31}$P SLIM with 3D proton images, (b) SLIM with water suppression techniques, (c) SLIM with a surface coil, (d) SLIM with an adiabatic pulse, (e) SLIM with a projection reconstruction technique. Finally, the potential sources of error, which come from deviations from the original assumptions, were analyzed experimentally
Risonanza magnetica nucleare per immagini in medicina ( Book )
1 edition published in 1983 in Italian and held by 1 WorldCat member library worldwide
Constrained image reconstruction and spin tagging techniques for functional MR imaging by Sudeep Chandra ( )
1 edition published in 1994 in English and held by 1 WorldCat member library worldwide
Magnetic Resonance Imaging (MRI) holds enormous potential for exploring the functional centers of a living brain in vivo. Among the MRI techniques a number of different approaches have provided initial success. The focus of this work is on applications of constrained image processing techniques for accelerated data acquisition in many different areas of MRI that have the promise to be useful in dynamic functional studies. In addition, some new variations of spin tagging techniques have been developed that might be useful in the future to study small micromotions in vivo such as microcirculation in capillaries
Nuclear magnetic resonance microscopy : new theoretical and technical developments by Xiaohong Zhou ( )
1 edition published in 1992 in English and held by 1 WorldCat member library worldwide
This dissertation describes some new developments in the theory, instrumentation and applications of nuclear magnetic resonance (NMR) microscopy. The purpose of this study is to theoretically analyze resolution limits in NMR microscopy and develop experimental techniques to achieve the highest possible spatial resolution for a variety of biomedical applications. In the theoretical analysis, resolution limits due to linewidth broadening, unbounded diffusion and signal-to-noise ratio were evaluated for both projection reconstruction and Fourier transform imaging techniques. The results indicate that projection reconstruction gives a higher signal-to-noise ratio and requires a smaller magnetic field gradient to overcome the resolution limit due to linewidth broadening. Experimentally, three-dimensional projection reconstruction techniques were employed to achieve the optimal spatial resolution with isotropic voxels. Using a custom-built NMR microscope, isotropic voxels as small as (6.4 $mu m)sp3$ were achieved on phantoms and tissue specimens. With this resolution, we have investigated the natural contrast phenomenon in fixed human brain tissue from the putamen and correlated the microscopic NMR images with the optical micrographs. Results obtained from this study clearly demonstrate that tissue structures, such as fiber tracts and capillary blood vessels, are well resolved in NMR images with endogenous $Tsb2$ contrast. Correlation between the microscopic NMR images and optical micrographs greatly assisted in the interpretations of the complicated tissue structures. We have also studied the effect of a contrast agent (dextran magnetite) on microscopic NMR images of fresh rat liver and spleen tissues and shown the importance of contrast agents in detecting microscopic tissue structures. To extend NMR microscopy to in vivo studies, an instrument using surface RF coils was developed. Performance of a set of surface coils spanning from 6 mm to 43 mm were theoretically evaluated and experimentally verified on phantoms with the same sample-loss as tissues. Both theoretical and experimental results indicate that isotropic resolution of the order of (50 $mu m)sp3$ is possible in the regions close to the surface ($sim2 cm)$ of an object under in vivo conditions. Several technical problems in NMR microscopy, including gradient-induced vibrations, slow motion, magnetic susceptibility artifacts, and extra echoes, were also discussed and solutions to minimize these problems were proposed and tested
Magnetic resonance contrast-enhancing agents whose effects are altered by electric fields by Shachar Frank ( )
1 edition published in 1993 in English and held by 1 WorldCat member library worldwide
The membrane potential is an important property of many cells and organelles. Changes in the potential of membranes control or accompany numerous biological processes including information transfer in neuronal networks. Magnetic resonance imaging (macroscopic and microscopic) is essentially a non-invasive 3-dimensional imaging modality and could record changes in membrane potential if they were accompanied by changes in water proton relaxation rates in the vicinity of the membrane, and thus become a powerful tool for studying neuronal activity and, ultimately, understanding how the brain functions. With that in mind, contrast-enhancing agents whose effects are changed by electric fields, similar in function to voltage sensitive dyes, were developed. It may also be possible to develop magnetic resonance contrast agents that respond to changes in temperature, pH, light, or concentrations of certain ions and molecules, as all these changes in the environment are known to induce volume phase transitions in some polyelectrolyte gels. A polyelectrolyte gel, sodium polyacrylate, that undergoes a volume phase transition when an electric field is applied, was modified in such a way as to make it magnetic by the incorporation of small superparamagnetic iron oxide particles into the polymer's network. A suspension of magnetic gel microparticles that shrunk when an electric field was applied also showed an increase in the transverse relaxation rate of the water. A similar change occurred when the magnetic gel microparticles were put in a 10% red blood cell suspension and the cells were hyperpolarized by adding valinomycin. These experiments should be extended to excitable cells, both in vitro and in vivo, including MRI experiments. Although the work concentrated on superparamagnetic-contrast agents, some preliminary work was carried out on Gd$sp{3+}$-bound (paramagnetic) polyelectrolyte gel microparticles which showed a small decrease in the relaxation rate when an electric field was applied. The mechanisms for the changes in relaxation rates that accompany the changes in size of the magnetic gel microparticles are not fully understood. Both long range effects of the magnetized gel microparticles on diffusing water molecules, and local changes within the shrinking or swelling gel microparticle can be important contributors
NMR imaging and spectroscopy ( Visual )
1 edition published in 1983 in English and held by 1 WorldCat member library worldwide
Dr. Lauterbur lectures on his work in nuclear magnetic resonance in medicine in conjunction with spectroscopy
Design and analysis of microcoils for NMR microscopy by Timothy L Peck ( Book )
1 edition published in 1995 in English and held by 1 WorldCat member library worldwide
ZEUGAMATOGRAPHY NUCLEAR MAGNETIC RESONANCE ( Recording )
1 edition published in 1979 in English and held by 0 WorldCat member libraries worldwide
 
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Alternative Names
Lauterbur, Paul Christian, 1929-2007
Languages
English (30)
Italian (1)
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