WorldCat Identities

Grubbs, Robert H.

Overview
Works: 115 works in 176 publications in 3 languages and 548 library holdings
Genres: Handbooks, manuals, etc 
Roles: Editor, Thesis advisor, Author, Honoree, Contributor
Classifications: QD305.H7, 660.299
Publication Timeline
Key
Publications about  Robert H Grubbs Publications about Robert H Grubbs
Publications by  Robert H Grubbs Publications by Robert H Grubbs
Most widely held works by Robert H Grubbs
Handbook of metathesis ( Book )
10 editions published in 2003 in English and held by 277 WorldCat member libraries worldwide
Metathesis in natural product synthesis strategies, substrates and catalysts by Janine Cossy ( Book )
5 editions published between 2010 and 2011 in English and held by 26 WorldCat member libraries worldwide
Emphasizing the impact of metathesis in natural product synthesis through the different types of key reactions, this is a comprehensive view of a hot topic. Written by top international authors, this ready reference is clearly structured and packed with important information, including representative experimental procedures for practical applications. A real must-have for anyone working in natural product synthesis
Applications in polymer synthesis ( Book )
3 editions published in 2003 in English and German and held by 24 WorldCat member libraries worldwide
Applications in organic synthesis ( Book )
3 editions published in 2003 in English and German and held by 22 WorldCat member libraries worldwide
Catalyst development ( Book )
3 editions published in 2003 in English and German and held by 22 WorldCat member libraries worldwide
Handbook of metathesis ( Book )
2 editions published in 2003 in English and held by 4 WorldCat member libraries worldwide
Handbook of metathesis ( Book )
2 editions published in 2003 in English and held by 4 WorldCat member libraries worldwide
Handbook of metathesis ( Book )
2 editions published in 2003 in English and held by 4 WorldCat member libraries worldwide
Handbook of metathesis ( )
1 edition published in 2003 in English and held by 3 WorldCat member libraries worldwide
New materials for biological applications prepared by olefin metathesis reactions by Heather Dawn Maynard ( )
2 editions published in 2001 in English and held by 3 WorldCat member libraries worldwide
With the advent of well-defined ruthenium olefin metathesis catalysts that are highly active and stable to a variety of functional groups, the synthesis of complex organic molecules and polymers is now possible; this is reviewed in Chapter 1. The majority of the rest of this thesis describes the application of these catalysts towards the synthesis of novel polymers that may be useful in biological applications and investigations into their efficacy. A method was developed to produce polyethers by metathesis, and this is described in Chapters 2 and 3. An unsaturated 12-crown-4 analog was made by template- directed ring-closing metathesis (RCM) and utilized as a monomer for the synthesis of unsaturated polyethers by ring-opening metathesis polymerization (ROMP). The yields were high and a range of molecular weights was accessible. In a similar manner, substituted polyethers with various backbones were synthesized: polymers with benzo groups along the backbone and various concentrations of amino acids were prepared. The results from in vitro toxicity tests of the unsubstituted polyethers are considered. The conditions necessary to synthesize polynorbornenes with pendent bioactive peptides were explored as illustrated in Chapter 4. First, the polymerization of various norbornenyl monomers substituted with glycine, alanine or penta(ethylene glycol) is described. Then, the syntheses of polymers substituted with peptides GRGD and SRN, components of a cell binding domain of fibronectin, using newly developed ruthenium initiators are discussed. In Chapter 5, the syntheses of homopolymers and a copolymer containing GRGDS and PHSRN, the more active forms of the peptides, are described. The ability of the polymers to inhibit human dermal fibroblast cell adhesion to fibronectin was assayed using an in vitro competitive inhibition assay, and the results are discussed. It was discovered that the copoymer substituted with both GRGDS and PHSR peptides was more active than both the GRGDS-containing homopolymer and the GRGDS free peptide. Historically, one of the drawbacks to using metathesis is the removal of the residual ruthenium at the completion of the reaction. Chapter 6 describes a method where the water soluble tris(hydroxymethyl)phosphine is utilized to facilitate the removal of residual ruthenium from RCM reaction products
Selectivity, activity, and stability of ruthenium-carbene based olefin metathesis initiators by Michael Ulman ( )
2 editions published in 2000 in English and held by 3 WorldCat member libraries worldwide
The olefin metathesis reaction has found many applications in polymer synthesis and more recently in organic synthesis. The use of single component late metal olefin metathesis catalysts has expanded the scope of the reaction to many new applications and has allowed for detailed study of the catalytic species
Olefin metathesis : a versatile tool for the synthesis of small to large molecules by Tae-Lim Choi ( )
2 editions published in 2004 in English and held by 3 WorldCat member libraries worldwide
The Olefin metathesis reaction ( )
2 editions published in 1978 in English and held by 3 WorldCat member libraries worldwide
Improving selectivity in olefin metathesis for small molecule synthesis and materials applications by Jean Li ( )
2 editions published in 2012 in English and held by 2 WorldCat member libraries worldwide
The first total synthesis of ()-lemonomycin and progress toward the total synthesis of (+)-cyanocycline A by Eric Robert Ashley ( Book )
1 edition published in 2006 in English and held by 2 WorldCat member libraries worldwide
The organometallic chemistry of aqueous ruthenium(II) with functionalized olefins : complex formation, isomerization, and metathesis chain transfer by Dominic V McGrath ( )
2 editions published in 1992 in English and held by 2 WorldCat member libraries worldwide
Tailoring polymer synthesis with designer ruthenium catalysts by Christopher W Bielawski ( Book )
1 edition published in 2003 in English and held by 2 WorldCat member libraries worldwide
Selectivity in ruthenium catalyzed olefin metathesis applications and origins by Benjamin K Keitz ( Book )
2 editions published in 2013 in English and held by 2 WorldCat member libraries worldwide
Development of the enantioselective oxidation of secondary alcohols and natural products total synthesis by Jeffrey Thomas Bagdanoff ( )
2 editions published in 2006 in English and held by 2 WorldCat member libraries worldwide
 
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Audience Level
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Audience level: 0.72 (from 0.10 for Grubbs, Ro ... to 0.92 for Robert How ...)
Alternative Names
Grubbs, Bob Howard 1942-
Grubbs, R.
Grubbs, R. 1942-
Grubbs, R. H.
Grubbs, R. H. 1942-
Grubbs, R. H. (Robert H.)
Grubbs, Robert Howard 1942-
Languages
English (51)
German (3)
Polish (1)
Covers