WorldCat Identities

Buxbaum, Joseph D.

Works: 5 works in 17 publications in 2 languages and 356 library holdings
Genres: Conference proceedings 
Roles: Editor, Author
Classifications: RC341, 616.8907
Publication Timeline
Most widely held works by Joseph D Buxbaum
The neuroscience of autism spectrum disorders by Joseph D Buxbaum( )

9 editions published between 2012 and 2013 in English and Italian and held by 321 WorldCat member libraries worldwide

Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention. Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years. With chapters authored by experts in each topic, the volume explores etiology, neuropathology, imaging, and pathways/models. Offering a broad background of ASDs with a unique focus on neurobiology, the volume offers more than the others on the market with a strictly clinical focus or a single authored perspective that fails to offer expert, comprehensive coverage. Researchers and graduate students alike with an interest in developmental disorders and autism will benefit, as will autism specialists across psychology and medicine looking to expand their expertise. Uniquely explores ASDs from a neurobiological angle, looking to uncover the molecular/cellular basis rather than to merely catalog the commonly used behavioral interventions Comprehensive coverage synthesizes widely dispersed research, serving as one-stop shopping for neurodevelopmental disorder researchers and autism specialists Edited work with chapters authored by leaders in the field around the globe - the broadest, most expert coverage available
Neurobiology of mental illness by Dennis S Charney( Book )

4 editions published between 2013 and 2014 in English and held by 31 WorldCat member libraries worldwide

The new edition of this definitive text reflects the continuing reintegration of psychiatry into the mainstream of biomedical science
Calsenilin - a neuronal calcium sensor by Christina Lilliehook( )

1 edition published in 2002 in English and held by 1 WorldCat member library worldwide

In our work, we have characterized calsenilin functionally in vitro in mammalian cells and in vivo in the calsenilin knockout mouse. We have found that overexpression of calsenilin increases the levels of Ca2+ in the endoplasmic reticulum. This sensitized cells to apoptotic stimuli; a finding that suggests that calsenilin could affect presenilin-associated apoptosis. Further, that calsenilin, which is normally a cytoplasmic protein, in the presence of Kv4.2 K+ channels translocates to the plasma membrane, and that this translocation is abolished if the N-terminal domain of calsenilin is deleted
The APP-binding protein FE65 complexes with teashirt proteins, inhibiting expression of the caspase-4, a primate-specific inflammatory caspase by Yuji Kajiwara( )

1 edition published in 2009 in English and held by 1 WorldCat member library worldwide

The Alzheimer amyloid protein precursor can be metabolized to produce Abeta, which accumulates in plaques in Alzheimer disease (AD). Several groups have shown that APP can bind the FE65 adaptor proteins and that this complex can regulate gene expression through nuclear signaling. In order to better understand the proteome that is associated with APP and FE65, we carried out two-hybrid studies to identify proteins interacting with a PTB domain of FE65. Of the proteins we identified, we focused on those that might be involved in nuclear signaling, and noted that in two screens (mouse and human brain), we identified Teashirt proteins as FE65 interactors. After validating that there was a potential for FE65-Teashirt in cultured cells, we then developed antibodies to Teashirt and confirmed the co-association of endogenous FE65 and Teashirt both in vitro and in vivo
Audience Level
Audience Level
  Kids General Special  
Audience level: 0.73 (from 0.47 for The emergi ... to 1.00 for The APP-bi ...)