WorldCat Identities

Walker, John E. 1941-

Overview
Works: 5 works in 6 publications in 1 language and 14 library holdings
Genres: Juvenile works  Action and adventure television programs  Children's television programs  Science fiction television programs  Animated television programs  Children's films 
Roles: Author
Publication Timeline
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Most widely held works by John E Walker
The mechanism of F₁F₀-ATPase( Book )

2 editions published in 2000 in English and held by 9 WorldCat member libraries worldwide

Activators and inhibitors of the fibrinolytic enzyme system : a study of their interactions and influence on thrombosis by John E Walker( Book )

1 edition published in 1981 in English and held by 2 WorldCat member libraries worldwide

The Transformers( Visual )

1 edition published in 2009 in English and held by 1 WorldCat member library worldwide

The Autobots and the Decepticons battle for control of Earth
Energy conversion in biology by John E Walker( Visual )

1 edition published in 2007 in English and held by 1 WorldCat member library worldwide

(CIT): Special 1:00 PM Director's Wednesday Afternoon Lecture Modern oxygen evolving photosynthesis requires more than 200 proteins. Many of them are organised in highly complex structures in the chloroplasts of green plants (and also in cyanobacteria) where incident light energy from the sun is entrapped in the carbohydrates and fats that provide our food with calorific value. We release the energy by respiration (controlled burning), consuming in the process most of the oxygen that we have breathed in. Of the 1000 or so proteins that are involved, about 100 of them are organised into the respiratory enzyme complexes in mitochondria that function as molecular machines to convert the redox energy derived from food-stuffs into adenosine triphosphate (ATP), the energy currency of biology. The final synthetic step is achieved by a remarkable molecular machine that has a mechanical rotary action. Its closest man-made analogue is the Wankel rotary engine. Its workings will be described and how such complex machines evolve will be discussed. Professor John Walker FRS is Director of the Medical Research Council Dunn Human Nutrition Unit in Cambridge, UK, since 1998. In 1974 he was recruited by Fred Sanger to the Laboratory of Molecular Biology in Cambridge, UK, and early on he helped to uncover details of the modified genetic code of mitochondrial DNA. In 1978 he began studying the ATP synthase from mitochondria and from bacteria, resulting in a complete sequence analysis of this complex enzyme from several species. This was the ouverture to his work leading, in 1994, to the resolution of the 3D structure of the headpiece and stalk of this remarkable energy transducer by X-ray crystallography. Most significantly, the crystal structure was obtained in conditions where three nominally identical units (alpha 3 beta 3) of the catalytic headgroup (F1), were each in a different configuration due to differential binding of adenine nucleotides, which at once pointed towards a rotary mechanism of ATP synthesis mediated by the asymmetry of the structure imposed by the rotating central stalk. Since this work, John has continued to unravel the secrets of this all-important enzyme for virtually all forms of life, including the structure of its membrane part (from yeast mitochondria), which demonstrated an unforeseen subunit stoichiometry that has led to new theories of the molecular mechanics of this intriguing nanomachine, the structure of the peripheral stalk or stator and the structure of the regulatory protein IF1 bound to the catalytic domain. Apart from these achievements, John has established the subunit composition of complex I, another highly complex membrane-bound enzyme of the mitochondrion, as well as identifying the functions of substrate transporter molecules in that membrane. In 1995 he was elected Fellow of the Royal Society. In 1997, he was awarded the Nobel Prize in Chemistry jointly with Dr Paul Boyer for their elucidation of the enzymatic mechanism underlying the synthesis of adenosine triphosphate (ATP). In 1999 he received his knighthood for his services to medical research from HRH The Prince of Wales. John's many other honours include the A.T. Clay Gold Medal in 1959, the Johnson Foundation Prize (University of Pennsylvania) in 1994, the CIBA medal and prize of the British Biochemical Society and the Peter Mitchell medal of the European Bioenergetics Conference, in 1996. He is a Foreign Member of L'Accademia Nazionale dei Lincei, Rome, Italy and the Royal Netherland Academy of Sciences, and a Foreign Associate of the National Academy of Sciences, USA. The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide
The Transformers( Visual )

1 edition published in 2009 in English and held by 1 WorldCat member library worldwide

The Autobots and the Decepticons battle for control of Earth
 
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.77 (from 0.30 for The Transf ... to 0.96 for Energy con ...)

Alternative Names
Ioannes Ernestus Walker

John E. Walker britischer Biochemiker, Nobelpreis für Chemie 1997

John E. Walker Brits moleculair bioloog

John E. Walker britský biochemik

John E. Walker Professor Sir John E. Walker FRS

John E. Walker químico inglés

John Ernest Walker

John Ernest Walker brytyjski biolog

John Ernest Walker chimico britannico

John Ernest Walker chimiste et biologiste moléculaire britannique

John Walker

Walker, J. E. (John E.), 1941-

Джон Вокер

Джон Уолкър

Джон Эрнст Уокер

Уокер, Джон Эрнст

ג'ון א' ווקר ביוכימאי בריטי, זוכה פרס נובל

جان ای واکر

جان واکر

جون ووكر

존 E. 워커

ジョン・E・ウォーカー

約翰·沃克

Languages