WorldCat Identities

Danishefsky, Samuel J.

Overview
Works: 20 works in 37 publications in 1 language and 603 library holdings
Roles: Author of introduction, Other, Honoree
Classifications: QD262, 547.08
Publication Timeline
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Most widely held works about Samuel J Danishefsky
 
Most widely held works by Samuel J Danishefsky
Glycopeptides and glycoproteins : synthesis, structure, and application by Valentin Wittmann( Book )

7 editions published in 2007 in English and held by 145 WorldCat member libraries worldwide

In the last 50 years molecular biology was dominated by the exploration of proteins and nucleic acids. Beside their role in energy metabolism, oligos- charides,which represent thethirdclass ofbiomacromolecules, have received less attention. Today it is well established that oligosaccharides are involved in many important biologicalregulation and recognition processes fromp- tein folding to cell-cell communication. Glycosylation of proteins is the most complexformofco-andposttranslationalmodi?cation. Thedeterminationof structure-function relationships, however, remains dif?cult due to the mic- heterogeneity of glycoproteins that exist in many different glycoforms. Thus chemical synthesis of glycoproteins and glycopeptides with de?ned glycan structures plays a pivotal role for the detailed determination of the role of protein glycosylation. This topic is covered by the ?rst two chapters of this bookdealingwiththechemicaland enzymatic synthesis ofglycopeptides and glycoproteins. The third chapter describes the construction of glycopeptide andglycoproteinmimetics containingnon-naturalstructuralelements. These so-calledneoglycopeptidesandneoglycoproteins,respectively,canprovide- sight on the importance of distinct structural elements on biological activity andmayhaveimproved propertiessuchasanincreased stability. Theappli- tion of synthetic glycopeptides, in many cases at the clinical level, as vaccines forbothcancerandHIVisthesubjectofthefourthchapter. Glycopeptide antibiotics are glycosylated secondary metabolites of bacteria and fungi that are synthesized by non-ribosomal peptide synthetases. Some of them serve as antibiotics of last resort in the treatment of nosocomial infections with enterococci and methicillin-resistant Staphylococcus aureus (MRSA) strains. Their structure, biosynthesis, and mode of action are summarized in the ?fth chapter. The last chapter covers current methods for the determination of high-resolution structures of glycopeptides and glycoproteins mainly based onNMRspectroscopy, X-raycrystallography,and molecular modeling
Recent applications of the glycal assembly method : solid-phase synthesis of oligosaccharides and glycoconjugates( Book )

2 editions published in 1995 in English and held by 15 WorldCat member libraries worldwide

Organic syntheses based on name reactions by Alfred Hassner( Book )

1 edition published in 2012 in English and held by 15 WorldCat member libraries worldwide

In addition to references and reviews this monograph covers several hundred organic syntheses based upon name reactions of which hundreds feature newer name reactions and the use of modern reagents
Total Synthesis of Eleutherobin and Analogs and Study of Anti-Cancer Mechanism( Book )

3 editions published between 2000 and 2002 in English and held by 3 WorldCat member libraries worldwide

Eleutherobin is a marine natural product discovered in 1994. It serves as one of the most potent anti-cancer agents mimicking Taxol. The proposed research is focused on improving the total synthesis of eleutherobin, and based on that developing eleutherobin analogs for biological studies. A modified eleutherobin synthesis is being studied. Compared to the initial Synthesis, the new synthesis is designed to improve the stereoselectivity of key steps and shorten the sequence
Special issue dedicated to Gilbert Stork( Book )

2 editions published in 1995 in English and held by 3 WorldCat member libraries worldwide

Progress in total synthesis by Sarah Etheredge Danishefsky( Book )

2 editions published in 1971 in English and held by 3 WorldCat member libraries worldwide

Recent applications of synthetic organic chemistry( Book )

1 edition published in 1997 in English and held by 2 WorldCat member libraries worldwide

Protein ligation and total synthesis I by LEI LIU( Book )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field
[Samuel Danishefsky, biographical materials]( )

in English and held by 1 WorldCat member library worldwide

Total synthesis of the potential anticancer vaccine KH-1 adenocarcinoma antigen by Prashant P Deshpande( )

1 edition published in 1997 in English and held by 1 WorldCat member library worldwide

Synthesis of Epothilone Analogs: Toward the Development of Potent Anticancer Drugs( )

2 editions published between 2000 and 2002 in English and held by 0 WorldCat member libraries worldwide

Having accomplished total syntheses of epoithilone A and B, we have been engaged in a new stage of investigation that involves development of efficient strategies for a large scale epothilone preparation and search for more potent analogues. Efficient and processable syntheses of key building blocks of 12,1 3-desoxyepothilone B (dEpoB) by catalytic asymmetric induction has been achieved. dEpoB is a potent anticancer agent, showing a highly promising therapeutic potential in the currently undergoing phase I study. The syntheses of two epothilone analogues, 15(S)-aza-12,13-desoxyepothilone B and the epimeric 15(R)-aza-12,13- -desoxyepothilone B have been accomplished. Tubulin binding and cytotoxicity profiles of these analogues have also been investigated. Another epothilone, 12,13-desoxyepothilone F (dEpoF), was synthesized and evaluated for antitumor potential. The results from an in vitro assay reveal that this new analogue is highly active against various tumor cell lines with a potency comparable to that of dEpoB. In particular, the growth of resistant tumor cells is inhibited by dEpoF at concentrations where paclitaxel (Taxol) is basically ineffective. A preliminary assessment of its in vivo activity is also promising. The new analogue, containing an additional hydroxyl group at C21, provides advantages over other epothilones in terms of water solubility and can serve as a readily functionalizable handle to produce other useful compounds for pertinent biological studies
Targeting Breast Cancer by Active Immunotherapy: Chemical Synthesis of Multiantigenic Unimolecular Antitumor Vaccines( )

1 edition published in 2004 in English and held by 0 WorldCat member libraries worldwide

The goal of developing methodology for the synthesis of carbohydrate antigens has been accomplished on the example of HIV antigens. The goal of developing methodology for incorporation of carbohydrates onto a peptidic backbone and construction of a unimolecular vaccine candidate has been accomplished. The divalent antigen structure was shown to be crucial for binding to an anti HIV antibody 2G12. The synthesis of cancer specific carbohydrate antigens and the work on construction of unimolecular anticancer vaccine are currently in progress
A Solid Support Synthesis and Novel Conjugation Methods of Breast Tumor Associated Antigen: Toward the Development of Cancer Vaccines( )

3 editions published between 1998 and 2000 in English and held by 0 WorldCat member libraries worldwide

Immunological study of Globo-H, a breast tumor associated carbohydrate antigen, has been producing promising results. As the demand for the supply of this antigen grows, the efficient production of enough material has become an urgent problem. We have been trying to solve this problem by two approaches: the solid support synthesis of Globo-H, and the development of efficient conjugation methods. For the solid support synthesis, solution phase direct roll-over reactions have been performed to verify the possibility that this method can be used to install the 2-amino-2-deoxy galactose moiety on the polymer support. From the results of these reactions, a tumor associated nonasaccharide antigen KM-i has been synthesized. To improve the conjugation yield of Globo-H to a carrier protein KLH (keyhole lympet hemocyanin), a model study has been carried out to implement an N-hydroxy succinimide ester conjugation method. At the same time, sufficient amounts of Globo-H have been synthesized by solution phase protocol for further immunocharacterization
Strategy Toward The Total Synthesis of Epothilones A and B( )

1 edition published in 1998 in English and held by 0 WorldCat member libraries worldwide

Epothilones are a class of promising antibreast cancer candidate. They were synthesized by three strategies. Structure - activity relationships were studied with the synthetic compounds. The first in vivo test of synthetic epothilone B is encouraging. Further chemical and biological studies are on going
Synthesis of Clustered ST-Antigens for the Development of Novel Breast Cancer Vaccines( )

2 editions published between 1999 and 2000 in English and held by 0 WorldCat member libraries worldwide

The development of efficient routes for the preparation of complex oligosacoharide or carbohydrate conjugates has been a goal in the Danishefsky group for some time. Synthetic investigations in this area can help to provide a detailed knowledge of the structural and chemical behavior of carbohydrates and their conjugates. Moreover, it has been known for some time now that specific types of glycolipids or glycoproteins, which are chemically detectable in normal cells, are more highly expressed in tumors. It should be noted that abnormally high levels of expression on tumor cells cause an antibody response, consequently rendering the cell- surface glycoconjugate a tumor-associated antigen. The idea of such glycoconjugates as tumor-associated antigens is the basis for using carbohydrates in the development of antitumor vaccines. Since tumor antigens and vaccine constructs are usually inaccessible from natural sources, it falls to the organic chemist to supply necessary quantities of carbohydrates, in the form of both glycolipids and glycopeptides
Silicon in organic synthesis by Ernest W Colvin( )

1 edition published in 1981 in English and held by 0 WorldCat member libraries worldwide

 
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Glycopeptides and glycoproteins : synthesis, structure, and application
Alternative Names
Danishefsky, S. 1936-

Danishefsky, S. J.

Danishefsky, S. J. 1936-

Danishefsky, S. J. (Samuel J.)

Danishefsky, Samuel

Danishefsky, Samuel 1936-

Samuel Danishefsky chimiste américain

Samuel Danishefsky US-amerikanischer Chemiker

Samuel J. Danishefsky Amerikaans scheikundige

Samuel J. Danishefsky amerikansk kemiker

Samuel J. Danishefsky amerikansk kemist

Samuel J. Danishefsky amerikansk kjemikar

Samuel J. Danishefsky amerikansk kjemiker

Samuel J. Danishefsky químico estadounidense

Данишефски, Сэмюэл

ساموئل جی. دانیشفسکی شیمی‌دان آمریکایی

サミュエル・ダニシェフスキー

塞缪尔·丹尼谢夫斯基

Languages
English (37)

Covers
Organic syntheses based on name reactions