WorldCat Identities

Danishefsky, Samuel J.

Overview
Works: 29 works in 50 publications in 1 language and 701 library holdings
Genres: Periodicals 
Roles: Author of introduction, Editor, Author, Honoree
Classifications: QD262, 547.2
Publication Timeline
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Most widely held works about Samuel J Danishefsky
 
Most widely held works by Samuel J Danishefsky
Glycopeptides and glycoproteins : synthesis, structure, and application by Valentin Wittmann( Book )

9 editions published in 2007 in English and held by 147 WorldCat member libraries worldwide

In the last 50 years molecular biology was dominated by the exploration of proteins and nucleic acids. Beside their role in energy metabolism, oligos- charides,which represent thethirdclass ofbiomacromolecules, have received less attention. Today it is well established that oligosaccharides are involved in many important biologicalregulation and recognition processes fromp- tein folding to cell-cell communication. Glycosylation of proteins is the most complexformofco-andposttranslationalmodi?cation. Thedeterminationof structure-function relationships, however, remains dif?cult due to the mic- heterogeneity of glycoproteins that exist in many different glycoforms. Thus chemical synthesis of glycoproteins and glycopeptides with de?ned glycan structures plays a pivotal role for the detailed determination of the role of protein glycosylation. This topic is covered by the ?rst two chapters of this bookdealingwiththechemicaland enzymatic synthesis ofglycopeptides and glycoproteins. The third chapter describes the construction of glycopeptide andglycoproteinmimetics containingnon-naturalstructuralelements. These so-calledneoglycopeptidesandneoglycoproteins,respectively,canprovide- sight on the importance of distinct structural elements on biological activity andmayhaveimproved propertiessuchasanincreased stability. Theappli- tion of synthetic glycopeptides, in many cases at the clinical level, as vaccines forbothcancerandHIVisthesubjectofthefourthchapter. Glycopeptide antibiotics are glycosylated secondary metabolites of bacteria and fungi that are synthesized by non-ribosomal peptide synthetases. Some of them serve as antibiotics of last resort in the treatment of nosocomial infections with enterococci and methicillin-resistant Staphylococcus aureus (MRSA) strains. Their structure, biosynthesis, and mode of action are summarized in the ?fth chapter. The last chapter covers current methods for the determination of high-resolution structures of glycopeptides and glycoproteins mainly based onNMRspectroscopy, X-raycrystallography,and molecular modeling
Progress in total synthesis( )

in English and held by 147 WorldCat member libraries worldwide

Organic syntheses based on name reactions : a practical guide to 750 transformations by Alfred Hassner( Book )

2 editions published in 2012 in English and held by 18 WorldCat member libraries worldwide

"An indispensable reference companion for chemistry students and researchers. Building on Hassner & Stumer's highly regarded 2nd edition, this new work reviews 750 reactions, with over 100 new stereoselective and regioselective reactions. Each A-Z entry provides a carefully condensed summary of valuable information that a chemist needs to understand and utilize these fundamental reactions in their work including brief practical details. Illustrated with real synthetic examples from the literature and ca. 3,400 references to the primary literature to aid further reading. Extensive indexes (name, reagent, reaction) and a very useful functional group transformation index help the reader fully navigate this extensive collection of important reactions. With its comprehensive coverage, superb organization and quality of presentation this long-awaited new edition belongs on the shelf of every organic chemist. Handy reference guide that explains 750 established named processes and methods that are trusted and used by organic chemists to synthesise or transform molecules -- Provides key data on each transformation including background, mechanism and uniquely to books in this area experimental details -- Extensive and multiple indexes allow the reader to search for information as and how they want and to rapidly plan transformations."--Provided by publisher
Progress in total synthesis [by] Sarah Etheredge Danishefsky [and] Samuel Danishefsky by Sarah Etheredge Danishefsky( Book )

5 editions published in 1971 in English and held by 9 WorldCat member libraries worldwide

Progress in total synthesis. v. 1 by Sarah Etheredge Danishefsky( Book )

1 edition published in 1971 in English and held by 8 WorldCat member libraries worldwide

Recent applications of the glycal assembly method : solid-phase synthesis of oligosaccharides and glycoconjugates( Book )

1 edition published in 1995 in English and held by 8 WorldCat member libraries worldwide

Organic reactions by William Garfield Dauben( Book )

in English and held by 4 WorldCat member libraries worldwide

Recent applications of the glycal assembly method : solid-phase synthesis of oligosaccharides and glycoconjugates( Book )

1 edition published in 1995 in English and held by 4 WorldCat member libraries worldwide

Special issue dedicated to Gilbert Stork( Book )

2 editions published in 1995 in English and held by 3 WorldCat member libraries worldwide

Progress in total synthesis by Sarah E Danishefsky( Book )

1 edition published in 1971 in Undetermined and held by 2 WorldCat member libraries worldwide

Total Synthesis of Eleutherobin and Analogs and Study of Anti-Cancer Mechanism( Book )

2 editions published between 2000 and 2001 in English and held by 2 WorldCat member libraries worldwide

Eleutherobin is a potent anti-cancer natural product. Progress on an improved eleutherobin synthesis is reported herein. Since PI has completed the postdoctoral training, this should be considered as the final progress report
Recent applications of synthetic organic chemistry( Book )

1 edition published in 1997 in English and held by 2 WorldCat member libraries worldwide

Applications of transition metal mediated cycloaddition reactions toward the synthesis of interesting natural products by Samuel J Danishefsky( Visual )

1 edition published in 1995 in English and held by 1 WorldCat member library worldwide

Glycals in organic synthesis the evolution of new strategies for the conversion assembly of oligosaccharides and other glycoconjugates by Samuel J Danishefsky( Visual )

1 edition published in 1995 in English and held by 1 WorldCat member library worldwide

A Solid Support Synthesis and Novel Conjugation Methods of Breast Tumor Associated Antigen: Toward the Development of Cancer Vaccines( )

1 edition published in 2000 in English and held by 0 WorldCat member libraries worldwide

N-linked glycopeptides and glycoproteins are important biomolecules. They been revealed to involve a various biological affairs. For the first time, we have achieved the total synthesis of a high mannose N-linked glycopeptide carrying full H-type II human blood group. In this study, we have developed: (a) an efficient method for constructing core high mannose structure which is essential for all N-linked glycoproteins; (b) a chemically selective and stereoselective method for N-glycosylation of peptide, which will be widely used for making N-glycopeptide for biological study; (c) an efficient synthetic method to prepare the suitably protected lactosamine spacer; (d) an efficient method to construct H-type trisaccharide unit
Synthesis of Epothilone Analogs: Toward the Development of Potent Anticancer Drugs( )

1 edition published in 2002 in English and held by 0 WorldCat member libraries worldwide

Epothilones are cytotoxic natural products that inhibit the growth of cancer cells by the same tubulin-stabilizing mechanism of Taxol. We have been developing a program in epothilone-based chemotherapy, and have succeeded in accomplishing efficient synthetic protocols to access large amounts of important analogs quickly. Our lead candidate, l2,l3-desoxyepothilone B (dEpoB), is currently in Phase I clinical trials. To further develop and screen a variety of strong back-up candidates in our clinical development program, we have made and tested a series of dehydro-desoxy-epothilones. In the process, we have also discovered an even more practical synthetic process toward the synthesis of our lead drug candidate, dEpoB. We have also examined the scope of synthetic modifications to the natural epothilone structure with regards to biological activity. These experiments include the expansion of the ring-size of the epothilones and introduction of trifluoromethyl groups. These studies demonstrate that the dehydroepothilones are viable cytotoxic agents, and that minimal ring-expansion strategies maintain the biological activity of the epothilones
Targeting Breast Cancer by Active Immunotherapy: Chemical Synthesis of Multiantigenic Unimolecular Antitumor Vaccines( )

1 edition published in 2004 in English and held by 0 WorldCat member libraries worldwide

The goal of developing methodology for the synthesis of carbohydrate antigens has been accomplished on the example of HIV antigens. The goal of developing methodology for incorporation of carbohydrates onto a peptidic backbone and construction of a unimolecular vaccine candidate has been accomplished. The divalent antigen structure was shown to be crucial for binding to an anti HIV antibody 2G12. The synthesis of cancer specific carbohydrate antigens and the work on construction of unimolecular anticancer vaccine are currently in progress
Synthesis of Clustered ST-Antigens for the Development of Novel Breast Cancer Vaccines( )

1 edition published in 1999 in English and held by 0 WorldCat member libraries worldwide

The development of efficient routes for the preparation of complex oligosaccharide or carbohydrate conjugates has been our immediate purpose. A more global goal would be that of recruiting the immune system to respond to malignant lesions. In our continuing chemical studies, we have undertaken to develop synthetic methodology of general applicability for the preparation of carbohydrates, in the form of glycolipids and glycopeptides, which mimic components of the accessible cell surface of tumor cells. The report herein focuses on successful syntheses of mucin related 0-linked glycopeptides, in particular the TF and 2,3-STF antigens. TF is observed on a variety of epithelial tumors and 2,3-STF is observed on a large number of breast tumors
 
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Glycopeptides and glycoproteins : synthesis, structure, and application
Alternative Names
Danishefsky, S. J.

Danishefsky, S. J. 1936-

Danishefsky, S. J. (Samuel J.)

Danishefsky, Samuel

Samuel Danishefsky chimiste amricain

Samuel Danishefsky US-amerikanischer Chemiker

Samuel J. Danishefsky amerikansk kemiker

Samuel J. Danishefsky amerikansk kemist

Samuel J. Danishefsky amerikansk kjemikar

Samuel J. Danishefsky amerikansk kjemiker

ساموئل جی. دانیشفسکی شیمی‌دان آمریکایی

サミュエル・ダニシェフスキー

塞缪尔丹尼谢夫斯基

Languages
English (42)

Covers
Organic syntheses based on name reactions : a practical guide to 750 transformations