WorldCat Identities

Hartl, F. Ulrich

Overview
Works: 23 works in 34 publications in 2 languages and 207 library holdings
Genres: Conference proceedings 
Roles: Speaker, Other, Author, Editor
Classifications: QH603.M5, 572.6
Publication Timeline
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Most widely held works by F. Ulrich Hartl
Protein targeting to mitochondria by F. Ulrich Hartl( )
7 editions published between 1996 and 2006 in English and held by 62 WorldCat member libraries worldwide
A large number of newly-synthesized polypeptides must cross one or several intracellular membranes to reach their functional locations in the eukaryotic cell. The mechanisms of protein trafficking, in particular the post-translational targeting and membrane translocation of proteins, are of fundamental biological importance and are the focus of intensive research world-wide. For more than 15 years, mitochondria have served as the paradigm organelle system to study these processes. Although key questions, such as how precisely proteins cross a membrane, still remain to be answered, exciting progress has been made in understanding the basic pathways of protein import into mitochondria and the components involved. In addition to a fascinating richness and complexity in detail, the analysis of mitochondrial protein import has revealed mechanistic principles of general significance: Major discoveries include the demonstration of the requirement of an unfolded state for translocation and of the essential role of molecular chaperones on both sides of the membranes in maintaining a translocation-competent conformation and in protein folding after import. It is becoming clear how a polypeptide chain is "reeled" across the membrane in an ATP-dependent process by the functional cooperation of membrane proteins, presumably constituting part of a transmembrane channel, with peripheral components at the trans-side of the membrane. In this volume, eminent experts in the field take the time to review the central aspects of mitochondrial biogenesis. The logical order of the 16 chapters is determined by the sequence of steps during protein import, starting with the events taking place in the cytosol, followed by the recognition of targeting signals, the translocation of precursor proteins across the outer and inner membranes, their proteolytic processing and intramitochondrial sorting, and finally their folding and oligomeric assembly. In addition, the mechanisms involved in the export of mitochondrially encoded proteins as well as recent advances in understanding the division and inheritance of mitochondria will be discussed
Bakterielle Endotoxine : chemische Konstitution und biologische Wirkung. Proteinfaltung in der Zelle / Franz-Ulrich Hartl by E. Th Rietschel( Book )
2 editions published in 1999 in German and held by 29 WorldCat member libraries worldwide
Chaperone mechanisms in cellular protein folding by F. Ulrich Hartl( )
2 editions published in 2007 in English and held by 21 WorldCat member libraries worldwide
Audio-visual presentation : The effect of protein aggregation on productive protein folding ; The function of GroEL and GroES as a folding cage for proteins ; Changes in energy landscape within the folding cage ; Cooperation of different chaperone systems in folding pathways: Hsp70 and chaperonins ; Binding of the Hsp70 homologue protein, DnaK, to newly-synthesized polypeptides ; The role of chaperone mechanisms in toxicity suppression of misfolded disease causing proteins ; Potential uses of the chaperone mechanisms in disease therapeutics
The interaction network of the GroEL chaperonin by F. Ulrich Hartl( Visual )
1 edition published in 2012 in English and held by 19 WorldCat member libraries worldwide
Regulation of the cytosolic stress response identification of positive and negative modulators by a Genome-Wide RNA interference screen by Christian Frank Löw( )
1 edition published in 2014 in English and held by 18 WorldCat member libraries worldwide
Structural characterization of chaperone assisted folding and assembly of RuBisCO by Bharathi Vasudeva Rao( )
1 edition published in 2009 in English and held by 13 WorldCat member libraries worldwide
Abstracts of papers presented at the 2008 meeting on molecular chaperones & stress responses : April 30-May 4, 2008 ( Book )
1 edition published in 2008 in English and held by 8 WorldCat member libraries worldwide
Abstracts of papers presented at the 2010 meeting on molecular chaperones & stress responses : May 4-May 8, 2010 ( Book )
1 edition published in 2010 in English and held by 7 WorldCat member libraries worldwide
Abstracts / 49th 'Mosbacher Kolloqium' Molecular Chaperones in Biology and Medicine : Mosbach, April 2-4, 1998. 146th Conference, 6th Photosynthesis Workshop 'Nordwest' ; Bielefeld, October 10, 1997. by 1998, Mosbach> Mosbacher Kolloquium. <49( Book )
1 edition published in 1998 in English and held by 7 WorldCat member libraries worldwide
Abstracts of papers presented at the 2012 Meeting on Molecular Chaperones & Stress Responses : May 1-May 5, 2012 by Meeting on Molecular Chaperones & Stress Responses( Book )
1 edition published in 2012 in English and held by 5 WorldCat member libraries worldwide
Die Steuerung peroxisomaler Enzymaktivitäten durch Schilddrüsenhormon in der Leber der Ratte by F. Ulrich Hartl( Book )
2 editions published in 1985 in German and held by 3 WorldCat member libraries worldwide
Rubisco folding and oligomeric assembly detailed analysis of an assembly intermediate by Amanda Windhof( )
1 edition published in 2011 in English and held by 2 WorldCat member libraries worldwide
Heat shock proteins in molecular medicine - misfolding diseases and cancer : EMBO-FEBS Workshop on Biology of Molecular Chaperones, Zakopane, Poland, May 28 - June 2, 2005 : [book of abstracts] by EMBO-FEBS Workshop on Biology of Molecular Chaperones( Book )
2 editions published in 2005 in English and held by 2 WorldCat member libraries worldwide
Abschlussbericht (final report) zum Projekt "Defeating protein folding diseases" ( )
2 editions published in 2007 in English and held by 2 WorldCat member libraries worldwide
Structure of green type Rubisco activase from Nicotiana tabacum by Mathias Michael Stotz( )
1 edition published in 2012 in English and held by 1 WorldCat member library worldwide
Real-time observation of Trigger factor function on translating ribosomes ( )
1 edition published in 2006 in Undetermined and held by 1 WorldCat member library worldwide
Molecular chaperones in protein folding : the art of avoiding sticky situations by F. Ulrich Hartl( Book )
1 edition published in 1994 in English and held by 1 WorldCat member library worldwide
Protein folding, degradation and molecular chaperones : a Keystone Symposium : Copper Mountain, Colorado, April 10-16, 1999 ( Book )
1 edition published in 1999 in English and held by 1 WorldCat member library worldwide
The cellular machinery of protein folding and its implications in human disease by F. Ulrich Hartl( Visual )
1 edition published in 2012 in English and held by 1 WorldCat member library worldwide
Prof Franz-Ulrich Hartl illustrated the main principles of chaperone action in the cytosol. He also discussed the role of the chaperone network in controlling protein homeostasis and preventing the deposition of disease-causing protein aggregates. He speculated on the prospect of pharmacologically activating cellular chaperone capacity to combat neurodegenerative diseases--
The Shaw Prize 2012 ( Visual )
1 edition published in 2012 in English and held by 1 WorldCat member library worldwide
"The Shaw Prize is in its 9th year, and sharing the award in Life Science and Medicine is Dr. Ulrich Hartl of the Max Planck Institute in Germany and Dr. Arthur Horwich of Yale University. They discovered that protein folding in cells needs molecular chaperones. This is now fundamental to cellular biology but has wide implications in the treatment of diseases, because cells become toxic when protein misfolds and forms aggregates."--TVB web site
 
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Alternative Names
Hartl, F. Ulrich.
Languages
English (26)
German (4)
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