WorldCat Identities

Varshavsky, Alexander

Overview
Works: 27 works in 30 publications in 2 languages and 58 library holdings
Genres: Conference papers and proceedings 
Roles: Author, Contributor
Classifications: PG3273, 575.2
Publication Timeline
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Most widely held works about Alexander Varshavsky
 
Most widely held works by Alexander Varshavsky
Zolotoĭ lotos : sbornik fantasticheskikh povesteĭ i rasskazov( Book )

1 edition published in 1961 in Russian and held by 9 WorldCat member libraries worldwide

Doroga v sto parsekov; nauchno-fantasticheskie povesti i rasskazy by Alex Varshavsky( Book )

2 editions published in 1959 in Russian and held by 4 WorldCat member libraries worldwide

Using ambient radio environment to support practical pervasive computing by Alex Varshavsky( Book )

2 editions published between 2008 and 2010 in English and held by 3 WorldCat member libraries worldwide

Mobile applications can benefit from increased awareness of the device's context. Unfortunately, existing solutions for inferring context require special purpose sensors or beacons on the mobile devices or in the physical environment. This requirement significantly limits the deployment of these solutions. In this thesis, I argue that mobile devices can infer a substantial amount of their context by leveraging their existing wireless interfaces to monitor ambient radio sources, such as GSM cell towers or WiFi access points. I focus on two important problems in context-aware computing: localization of mobile devices and detecting proximity between mobile devices for authentication purposes. Specifically, I present an accurate localization system based on fingerprinting of GSM signals. I show that the key to more accurate GSM localization is the use of wide signal strength fingerprints that include readings from a large number of base stations. Next, I present a method that addresses the key drawback of fingerprint-based localization systems---the need to collect extensive measurements to train the system in every target environment. Finally, I show how radio environment sensing can be used to secure the communication of devices that come within close proximity. Removing the need for additional hardware on the mobile devices and in the physical environment renders the approach that I present amenable for widespread deployment
Alʹfa Eridana; sbornik nauchno-fantasticheskikh rasskazov by Alex Varshavsky( Book )

1 edition published in 1960 in Russian and held by 3 WorldCat member libraries worldwide

Build your DNA kit by William G Thilly( Book )

1 edition published in 1986 in English and held by 2 WorldCat member libraries worldwide

Targeting the absence: Homozygous DNA deletions as immutable signposts for cancer therapy by Alex Varshavsky( )

1 edition published in 2007 in Undetermined and held by 1 WorldCat member library worldwide

Many cancers harbor homozygous DNA deletions (HDs). In contrast to other attributes of cancer cells, their HDs are immutable features that cannot change during tumor progression or therapy. I describe an approach, termed deletion-specific targeting (DST), that employs HDs (not their effects on RNA/protein circuits, but deletions themselves) as the targets of cancer therapy. The DST strategy brings together both existing and new methodologies, including the ubiquitin fusion technique, the split-ubiquitin assay, zinc-finger DNA-recognizing proteins and split restriction nucleases. The DST strategy also employs a feedback mechanism that receives input from a circuit operating as a Boolean OR gate and involves the activation of split nucleases, which destroy DST vector in normal (nontarget) cells. The logic of DST makes possible an incremental and essentially unlimited increase in the selectivity of therapy. If DST strategy can be implemented in a clinical setting, it may prove to be curative and substantially free of side effects
The N-end rule: Functions, mysteries, uses by Alex Varshavsky( )

1 edition published in 1996 in Undetermined and held by 1 WorldCat member library worldwide

The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Similar but distinct versions of the N-end rule operate in all organisms examined, from mammals to fungi and bacteria. In eukaryotes, the N-end rule pathway is a part of the ubiquitin system. I discuss the mechanisms and functions of this pathway, and consider its applications
Ubiquitin Ligases of the N-End Rule Pathway: Assessment of Mutations in UBR1 That Cause the Johanson-Blizzard Syndrome( )

1 edition published in 2012 in English and held by 1 WorldCat member library worldwide

Vse, chto vyshe materika by Alex Varshavsky( Book )

1 edition published in 1964 in Russian and held by 1 WorldCat member library worldwide

Codominance and toxins: A path to drugs of nearly unlimited selectivity by Alex Varshavsky( )

1 edition published in 1995 in Undetermined and held by 1 WorldCat member library worldwide

The effectiveness of drugs is often limited by their insufficient selectivity. I propose designs of therapeutic agents that address this problem. The key feature of these reagents, termed comtoxins (codominance-mediated toxins), is their ability to utilize codominance, a property characteristic of many signals in proteins, including degradation signals (degrons) and nuclear localization signals. A comtoxin designed to kill cells that express intracellular proteins P1 and P2 but to spare cells that lack P1 and/or P2 is a multidomain fusion containing a cytotoxic domain and two degrons placed within or near two domains P1* and P2* that bind, respectively, to pi and P2. In a cell containing both P1 and P2, these proteins would bind to the P1* and P2* domains of the comtoxin and sterically mask the nearby (appropriately positioned) degrons, resulting in a long-lived and therefore toxic drug. By contrast, in a cell lacking P1 and/or P2, at least one of the comtoxin's degrons would be active (unobstructed), yielding a short-lived and therefore nontoxic drug. A comtoxin containing both a degron and a nuclear localization signal can be designed to kill exclusively cells that contain P1 but lack P2. Analogous strategies yield comtoxins sensitive to the presence (or absence) of more than two proteins in a cell. Also considered is a class of comtoxins in which a toxic domain is split by a flexible insert containing binding sites for the target proteins. The potentially unlimited, combinatorial selectivity of comtoxins may help solve the problem of side effects that bedevils present-day therapies, for even nonselective delivery of a comtoxin would not affect cells whose protein "signatures" differ from the targeted one
Detecting and measuring cotranslational protein degradation in vivo by Glenn C Turner( )

1 edition published in 2000 in English and held by 1 WorldCat member library worldwide

Sotsial'no-ekonomicheskie problemy rossiiskoi nauki : dolgosrochnye aspekty razvitiia by Alex Varshavsky( )

1 edition published in 1998 in Russian and held by 1 WorldCat member library worldwide

Build your DNA kit by William G Thilly( Visual )

1 edition published in 1987 in English and held by 1 WorldCat member library worldwide

Veka, skulʹptory, pamjatniki by Boris Ionovich Brodskiĭ( Book )

1 edition published in 1962 in Russian and held by 1 WorldCat member library worldwide

On the possibility of metabolic control of replicon "misfiring": Relationship to emergence of malignant phenotypes in mammalian cell lineages by Alex Varshavsky( )

1 edition published in 1981 in Undetermined and held by 1 WorldCat member library worldwide

Constraints of a multireplicon chromosomal organization and of the necessity to maintain constant gene dosages demand that each origin of replication in a eukaryotic cell "fire" (initiate replication) only once per cell cycle. The central idea of this work is that a low probability of an extra ("illegitimate") round of DNA replication (called below "replicon misfiring") within any given chromosomal domain could be increased by certain substances of either intra- or extracellular origin. The term "firone" is proposed for such a substance. It is shown that existence of firones could greatly speed up evolution of cellular systems under selection pressure, a developing tumor being one example of such a system. Experimentally testable predictions of the firone hypothesis are discussed
The N-end rule at atomic resolution by Alex Varshavsky( )

1 edition published in 2008 in Undetermined and held by 1 WorldCat member library worldwide

The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. The N-end rule pathway, ubiquitin-dependent in eukaryotes, is also present in prokaryotes, which lack the ubiquitin system. An illuminating new study presents the crystal structure of a bacterial N-end rule recognition component in complex with a peptide containing a cognate degradation signal
Three decades of studies to understand the functions of the ubiquitin family by Alex Varshavsky( Book )

1 edition published in 2012 in Undetermined and held by 1 WorldCat member library worldwide

Many intracellular proteins are metabolically unstable or can become unstable during their lifetime in a cell. The in vivo half-lives of specific proteins range from less than a minute to many days. Among the functions of intracellular proteolysis are the elimination of misfolded or otherwise abnormal proteins; maintenance of amino acid pools in cells affected by stresses such as starvation; and generation of protein fragments that act as hormones, antigens, or other effectors. One major function of proteolytic pathways is the selective destruction of proteins whose concentrations must vary with time and alterations in the state of a cell. Short in vivo half-lives of such proteins provide a way to generate their spatial gradients and to rapidly adjust their concentration or subunit composition through changes in the rate of their degradation. The regulated (and processive) degradation of intracellular proteins is carried out largely by the ubiquitin–proteasome system (Ub system), in conjunction with autophagy-lysosome pathways. Other contributors to intracellular proteolysis include cytosolic and nuclear proteases, such as caspases, calpains, and separases. They often function as “upstream” components of the Ub system, which destroys protein fragments that had been produced by these (nonprocessive) proteases. Ub, a 76-residue protein, mediates selective proteolysis through its enzymatic conjugation to proteins that contain primary degradation signals (degrons (1)), thereby marking such proteins for degradation by the 26S proteasome, an ATPdependent multisubunit protease. Ub conjugation involves the formation of a poly-Ub chain that is linked (in most cases) to the ε-amino group of an internal Lys residue in a substrate protein. Ub is a “secondary” degron, in that Ub is conjugated to proteins that contain primary degradation signals. Ub has nonproteolytic functions as well. The design of the Ub system is summarized in Fig. 1
Dynamic analysis of active faults in Israel : Final report submitted to the Ministry of Energy and Infrastructure by Alex Varshavsky( Book )

1 edition published in 1993 in English and held by 1 WorldCat member library worldwide

ACM HotMobile 2013 the 14th Workshop on Mobile Computing Systems & Applications : February 26-27, 2013 Jekyll Island, Georgia, USA by IEEE Workshop on Mobile Computing Systems and Applications( )

1 edition published in 2013 in English and held by 0 WorldCat member libraries worldwide

New Classes of Conditional Toxins as Therapeutic Agents Against Breast Cancer( )

2 editions published between 2000 and 2001 in English and held by 0 WorldCat member libraries worldwide

During the second year of support by the grant DAMDl7-98-l-8042 (The Idea Grant) we focused on the following projects: 1) Further development of signal-regulated, cleavage-mediated toxins. During this year, we completed the work on the CUP9-mediated, HIV protease-dependent conditional toxins. A paper describing these results is nearly finished, and will be submitted for publication this summer. 2) The effort of the previous two years to construct better portable degrons (degradation signals) that can be used, in particular, for designing of conditional toxins was successful. A paper describing these results was published at the end of 1999 (Suzuki & Varshavsky. Degradation signals in the lysine-asparagine sequence space. EMBO J. 18:6017-6026, 1999). 3) In 1999, we completed the construction of a bivalent inhibitor of the N-end rule pathway, a useful reagent for conditional-toxin projects, and published this new approach (Kwon & Varshavsky. Bivalent inhibitor of the N-end rule pathway. J. Biol. Chem. 274:18135-18139, 1999). 4) Other projects that encompass the subject of this grant are under way. They are briefly described below
 
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Alternative Names
Alexander Varshavsky Amerikaans biochemicus

Alexander Varshavsky biochimico e insegnante russo

Alexander Varshavsky russisch-US-amerikanischer Biochemiker und Professor am California Institute of Technology

Varshavskii, A.

Varshavsky, A.

Варшавский, Александр Яковлевич

アレクサンダー・バーシャフスキー

亚历山大·瓦尔沙夫斯基

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