WorldCat Identities

Venkatraman, Ganesh

Overview
Works: 7 works in 8 publications in 3 languages and 19 library holdings
Genres: Comedy films  Drama  Romance films  Romantic comedy films  Action and adventure films 
Roles: Actor, Author
Publication Timeline
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Most widely held works by Ganesh Venkatraman
Tīyā vēlai ceyyaṇum Kumāru = Theeya velai seiyyanum Kumaru( Visual )

1 edition published in 2013 in Tamil and held by 6 WorldCat member libraries worldwide

Kumar falls in love with Sanjana. Unable to express his love, he seeks guidance from 'love guru' Mokia. Matters queer when Mokia finds out Kumar is in love with his sister
Apiyum nān̲um = Abhiyum naanum( Visual )

1 edition published in 2009 in Tamil and held by 3 WorldCat member libraries worldwide

During a walk to the park Raghuram meets Sudhakar and tells him about his many experiences with his daughter Abhi. Raghuram is the loving husband of Anu and the worrisome as well as caring father of the only daughter Abhi. As Abhi grows up, Raghuram and Abhi become best friends. When Abhi gets accepted to a prestigious college in Delhi, Raghuram is shocked. He wearily accepts. Abhi returns after two years. She tells she is in love with a young man in Delhi. Raghuram is angry and scared. Anu later informs Raghuram that their future son-in-law will be staying with them for a while. Raghuram meets his future son-in-law, Joginder Singh (Ganesh Venkatraman), he is taken aback, because Joginder is a sardarji! Whether Raghuram accepts his daughter's love or not? Does this marriage between Abhi and Joginder happens or not forms the climax of the story
The Angrez( Visual )

1 edition published in 2006 in Hindi and held by 3 WorldCat member libraries worldwide

While on a sight-seeing tour of historic Charminar, a couple of young software engineers end up in a fracas with natives of the old city in Hyderabad. Meanwhile, another group of thugs trries to kidnap the engineers to extract a ransom, believing all software engineers are rich
Regulation of lysophosphatidate-induced mechanisms of chemo-resistance by Ganesh Venkatraman( )

1 edition published in 2015 in English and held by 2 WorldCat member libraries worldwide

Systemic chemotherapy in combination with local intervention through surgery and radiotherapy are effective treatments for breast cancers. Chemotherapy is often used in patients with early signs of disease to effectively shrink the tumor and prevent metastasis before surgical excision of the tumor. However, relapse occurs in some of these patients due to the presence of remnant cancer cells that are resistant to chemotherapy. These cancer cells may acquire additional resistance mechanisms resulting in multi-drug resistance and treatment failure. Aggressive tumors show inherently poor sensitivity to chemotherapeutics. Studies primarily based on cell culture models have identified mechanisms of chemo-resistance. These mechanisms include alterations in drug accumulation, increased drug metabolism, altered DNA damage response, evasion of cell-death and decreased ceramide accumulation. In animal models of cancer, additional complexity arises from signaling cross-talk among the cancer cells, stroma, extracellular matrix and the vasculature in the tumor microenvironment that contribute to the development of multi-drug resistance. Cytokines, chemokines and growth factors secreted into the tumor microenvironment represent a hurdle to successful chemotherapy by making the tumors inherently resistant and contributing to development of additional resistance. We examined the mechanism by which extracellular lysophosphatidate (LPA), which is produced by the secreted enzyme, autotaxin (ATX), contributes to multi-drug resistance using breast, thyroid, liver and lung cancer cells. LPA acts through its G-protein coupled receptor, LPA1-6, to promote survival and proliferation in cancers. We discovered that LPA increased the stability and nuclear localization of the transcription factor Nuclear Factor, Erythroid 2-Like 2 or Nrf2. Nrf2, a master regulator of the antioxidant response, promotes resistance to chemotherapeutics through increased metabolism, conjugation and export of drugs from the cell. We showed that LPA, through the activation of LPA1 receptors and phosphatidylinositol 3-kinase (PI3K), increased Nrf2 stabilization and the expression of multi-drug resistance transporters (MDRT) and antioxidant genes. LPA increased the efflux of substrates of the MDRT, which includes chemotherapeutics such as doxorubicin. Consequentially, LPA protected cancer cells from doxorubicin- and etoposideinduced apoptosis. We tested these results in vivo using a syngeneic 4T1 breast cancer model. Blocking LPA production with ONO-8430506, a competitive ATX inhibitor, decreased the expression of Nrf2 and Nrf2-regulated genes in breast tumors. Combining 4 mg/kg doxorubicin every third day with 10 mg/kg ONO- 8430506 every day decreased tumor growth and metastasis to lungs and liver by >70%, whereas doxorubicin alone had no significant effect on tumor growth. Additionally, we show increased expression of Nrf2 in the primary tumors of breast cancer patients, who have a recurrence following surgery and chemotherapy. We also demonstrate a novel concept of chemotherapy-induced increases in inflammation and ATX production as a mediator of resistance to oxidative damage in the 4T1 tumors. Increased expression of Nrf2 and its targets were also observed in tamoxifen-treated breast cancer cells and tumors. Inhibition of ATX overcomes this vicious cycle of inflammation, LPA production and resistance to oxidative damage. Finally, we examined another aspect of LPA signaling that contributes to increased resistance to chemotherapeutics. This involves increased activation and expression of sphingosine kinase 1 (SK1), which results in formation of sphingosine 1-phosphate (S1P) in the cells. LPA-induced translocation of SK1 to membranes, which constitutes an activation step, is higher in doxorubicin-resistant cancer cells when compared to their isogenic controls. Additionally, the doxorubicin-resistant cancer cells have increased expression of the MDRT and S1P receptors. We propose that extracellular LPA coordinates S1P signaling in cancer cells. This is through activation of SK1, secretion of S1P through the MDRT and increased signaling of secreted S1P through the S1P receptors. Overall, our studies have demonstrated a potentially important role for LPA signaling in increasing resistance to chemotherapies and development of multi-drug resistance. This is through the increased expression of Nrf2 and transcription of antioxidant and MDRT genes. Our study also provides a practical strategy for targeting LPA signaling in cancers by blocking LPA production with ATX inhibitors. There are no ATX inhibitors in the clinic. Inhibition of ATX could be a useful strategy in improving the efficacy of existing cancer therapies and to prevent the development of chemo-resistance in patients
Tiyā vēlai ceiyanum Kumāru = Theeya velai seiyyanum Kumaru( Visual )

2 editions published in 2014 in Tamil and held by 2 WorldCat member libraries worldwide

Kumar falls in love with Sanjana. Unable to express his love, he seeks guidance from 'love guru' Mokia. Matters queer when Mokia finds out Kumar is in love with his sister
Ivan̲ vēr̲amātiri = Ivan veramathiri( Visual )

1 edition published in 2013 in Tamil and held by 2 WorldCat member libraries worldwide

Gunasekaran, a socially responsible youth, kidnaps Easwaran, the brother of Sadasivam, the law minister, after the latter orchestrates violence among students. Sadasivam loses his post and Guna releases his captive but Easwaran wants revenge
Targeting IGF1R pathway in cancer with microRNAs: How close are we?( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

ABSTRACT: Cancer of the head and neck are the most common cancers in India and account for 30% of all cancers. At molecular level, it could be attributed to the overexpression of growth factors like IGF1-R, EGFR, VEGF-R and deregulation of cell cycle regulators and tumor suppressors. IGF1-R is an emerging target in head and neck cancer treatment, because of its reported role in tumor development, progression and metastasis. IGF1R targeted agents are in advanced stages of clinical development. Nevertheless, these agents suffer from several disadvantages including acquired resistance and toxic side effects. Hence there is a need for developing newer agents targeting not only the receptor but also its downstream signaling. miRNAs are considered as master regulators of gene expression of multiple genes and has been widely reported to be a promising therapeutic strategy. This review discusses the present status of research in both these arenas and emphasizes the role of miRNA as a promising agent for biologic therapy
 
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.63 (from 0.44 for Tiyā vēl ... to 0.89 for Targeting ...)

Alternative Names
Ganes Venkatraman

Ganesh Venkatraman acteur indien

Ganesh Venkatraman actor indio

Ganesh Venkatraman Indiaas acteur

Ganesh Venkatraman Indian actor

Ganesh Venkatraman indisk skådespelare

Ganesh Venkatraman indisk skodespelar

Ganesh Venkatraman indisk skuespiller

Ganesh Venkatraman pemeran asal India

গণেশ ভেঙ্কটরমন ভারতীয় অভিনেতা

Languages
Tamil (5)

English (2)

Hindi (1)