WorldCat Identities

Skerritt, Matthew P.

Works: 3 works in 30 publications in 1 language and 893 library holdings
Genres: Music 
Roles: Author, Creator
Classifications: QA76.95, 510.285536
Publication Timeline
Most widely held works by Matthew P Skerritt
An introduction to modern mathematical computing : with Mathematica by Jonathan M Borwein( Book )

27 editions published between 2011 and 2012 in English and held by 177 WorldCat member libraries worldwide

Thirty years ago mathematical, as opposed to applied numerical, computation was difficult to perform and so relatively little used. Three threads changed that: the emergence of the personal computer; the discovery of fiber-optics and the consequent development of the modern internet; and the building of the Three ?M?s? Maple, Mathematica and Matlab. We intend to persuade that Mathematica and other similar tools are worth knowing, assuming only that one wishes to be a mathematician, a mathematics educator, a computer scientist, an engineer or scientist, or anyone else who wishes/needs to use mathematics better. We also hope to explain how to become an "experimental mathematician" while learning to be better at proving things. To accomplish this our material is divided into three main chapters followed by a postscript. These cover elementary number theory, calculus of one and several variables, introductory linear algebra, and visualization and interactive geometric computation

1 edition published in 2009 in English and held by 2 WorldCat member libraries worldwide

The molecular and biophysical mechanisms by which Kv4 voltage-sensitive K+ channels respond to adjustments in membrane voltage are presently unresolved. With respect to inactivation gating, there is strong evidence that Shaker-like N- and P/C-type mechanisms are not involved. Kv4 channels also display prominent inactivation from pre-activated closed-states (closed-state inactivation, CSI), a process which is absent in Shaker (Kv1) channels. As in Shaker, voltage sensitivity in Kv4 is thought to be conferred by positively charged residues localized to the fourth transmembrane segment (S4) of the voltage-sensing domain. Kv1 channels possess four basic arginine residues (R1 - R4) that are responsible for carrying the majority of gating charge. In Kv4 channels, however, R1 is replaced by a neutral valine at position 287.^In the absence of confirmed mechanisms underlying several gating transitions in Kv4.3, I hypothesized that the S4 voltage sensor domain may serve a primary regulatory role, specifically for the processes of closed-state inactivation and recovery. To test this hypothesis I analyzed the effects of charge elimination at positions 290, 293, and 296 (R2 - R4 using Shaker nomenclature) by mutation to the uncharged residue alanine (A). The R to A mutants eliminated individual positive charge while significantly reducing side chain volume and hydrophilic character. Their novel effects on gating may thus have been the result of electrostatic and/or structural perturbations. To address this issue, I next comparatively analyzed arginine to glutamine (R to Q) mutations at the same three positions. This maneuver maintained positive charge elimination of the R to A mutants while partially restoring native side chain volume and hydrophilic properties.^To test whether the lack of charge at position 287 was responsible for noted differences in voltage sensitivity between Kv1 and Kv4.3, I next examined the role of charge addition at the site by mutation to arginine. With all three studies implicating a primary role for the S4 voltage sensor in regulating CSI and recovery, I examined these processes in greater detail through application of elevated extracellular potassium in the presence or absence of KChIP2b. Lastly, I explored the importance of potential electrostatic interactions between S2 and S3 negatively charged residues and positively charged K299 and R302 in S4. Through these studies I conclude that the S4 domain in Kv4.3 is responsible for regulating not only activation and deactivation processes, but also those of closed-state inactivation and recovery. In contrast to Shaker channels, closed-state inactivation appears to possess inherent voltage-dependence, or is uniquely coupled to activation.^With the kinetics of deactivation and recovery processes paralleled across the range of conditions analyzed, I suggest that these processes are likely coupled. Finally, it is suggested that S4 may be oriented in the transmembrane electrical field unique from its position in Shaker, so that the transmembrane electrical field resides across R290 in the resting state. Taken together, these results support the argument that a more complicated gating model exists in Kv4.3 as compared to Kv1 channels, and that the regulation of this gating is determined largely by the S4 voltage sensor domain
Live in Israel by Matisyahu( Visual )

1 edition published in 2006 in English and held by 1 WorldCat member library worldwide

The DVD features live footage of Matisyahu's first concert in Israel as well as his latest music video, for Jerusalem (Out of Darkness Comes Light). DVD also contains 11 interview with Matisyahu
Audience Level
Audience Level
  Kids General Special  
Audience level: 0.44 (from 0.34 for Live in Is ... to 0.82 for ELUCIDATIO ...)

An introduction to modern mathematical computing : with Mathematica
Alternative Names
Skerritt, M. P.

Skerritt, Matt.

Skerritt, Matthew.

English (29)