WorldCat Identities

Chea Sim

Works: 3 works in 3 publications in 2 languages and 3 library holdings
Publication Timeline
Most widely held works about Chea Sim
Most widely held works by Chea Sim
Raṭṭhadhammanuññ kamraṅ cpâp, 1993-1998 by Cambodia( Book )

1 edition published in 1998 in Khmer and held by 1 WorldCat member library worldwide

Comprising the constitution and constitutional amendments (1993-1998) of Cambodia; and collection of laws on various subjects
Amyloid-b and Alzheimer's disease type pathology differentially affects the calcium signalling toolkit in astrocytes from different brain regions( )

1 edition published in 2013 in English and held by 1 WorldCat member library worldwide

The entorhinal-hippocampal circuit is severely affected in Alzheimer's disease (AD). Here, we demonstrate that amyloid-beta (Abeta) differentially affects primary cultured astrocytes derived from the entorhinal cortex (EC) and from the hippocampus from non-transgenic controls and 3xTg-AD transgenic mice. Exposure to 100 nM of Abeta resulted in increased expression of the metabotropic glutamate receptor type 5 (mGluR5) and its downstream InsP3 receptor type 1 (InsP3R1) in hippocampal but not in EC astrocytes. Amplitudes of Ca(2+) responses to an mGluR5 agonist, DHPG, and to ATP, another metabotropic agonist coupled to InsP3Rs, were significantly increased in Abeta-treated hippocampal but not in EC astrocytes. Previously we demonstrated that senile plaque formation in 3xTg-AD mice triggers astrogliosis in hippocampal but not in EC astrocytes. The different sensitivities of the Ca(2+) signalling toolkit of EC versus hippocampal astrocytes to Abeta may account for the lack of astrogliosis in the EC, which in turn can explain the higher vulnerability of this region to AD
Audience Level
Audience Level
  Kids General Special  
Audience level: 0.93 (from 0.86 for Raṭṭhadh ... to 0.97 for Amyloid-b ...)

Alternative Names
Chea, Sim

Chea Sim Cambodian politician

Chea Sim homme politique cambodgien.

Chea Sim kambodschanischer Politiker

Chea Sim politico cambogiano

Chea Sim político camboyano

Chea Sim politicus uit Cambodja (1932-2015)

Jā, Sí̄m

Sim, Chea

Sí̄m, Jā

Чеа Сим

สมเด็จอัครมหาธรรมโพธิศาล เจีย ซีม



English (2)

Khmer (1)