WorldCat Identities

Honjo, T. (Tasuku) 1942-

Overview
Works: 45 works in 157 publications in 2 languages and 4,046 library holdings
Roles: Editor, Author, Other
Publication Timeline
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Most widely held works by T Honjo
Immunoglobulin genes by Tasuku Honjo( )

25 editions published between 1988 and 2014 in English and Undetermined and held by 1,696 WorldCat member libraries worldwide

The immunoglobulin gene complex is responsible for generating an extraordinarily wide range of antibodies, each possessing a unique antigen specificity. The Second Edition of Immunoglobulin Genes brings the reader up to date with the rapid progress in our understanding of this system. Firmly established as the definitive book on the topic, it provides a fully comprehensive account of the organization, function, rearrangement and expression of these and related genes. Since the publication of the first edition, the work has been extensively revised and updated to cover new research data on human immunoglobulin genes as well as mammalian and lower vertebrate systems. New chapters include "Somatic mutation and B cell Maturation", "Antigen receptors" and "B lymphocyte tolerance in the mouse." For the immunologist, there are detailed descriptions of the molecular mechanisms which generate this diverse range of antibodies and the tight regulation of the genes encoding them. Molecular biologists will find discussions of important phenomena including gene rearrangement, differential splicing and deletion in the context of immunoglobulin genes. The excitement of research on immunoglobulin genes is conveyed by the range and complexity of issues discussed here; the book contains invaluable information for clinicians and research scientists with an interest in the immune response. * Conveys the excitement of research on immunoglobulin genes by the range and complexity of issues * Contains invaluable information for clinicians and research scientists with an interest in the immune response * For the Immunologist * Detailed descriptions of the molecular mechanisms generating this diverse range of antibodies and the regulation of genes encoding them * For the Molecular Biologist * Discusses important phenomena including gene rearrangement, differential splicing, and deletion in the context of immunoglobulin genes
Molecular biology of B cells by T Honjo( )

24 editions published between 2003 and 2015 in English and held by 676 WorldCat member libraries worldwide

A key comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All these developmental and stimulatory processes are described in molecular and genetic terms to give a clear understanding of complex phenotypes for those who are specialised in immunology as well as in other biomedical disciplines. The molecular basis of many diseases due to B cell abnormality are discussed and the new technology that indicates medical applications for antibodies is highlighted
Gut-associated lymphoid tissues by Tasuku Honjo( )

14 editions published in 2006 in English and held by 562 WorldCat member libraries worldwide

The intestine is colonized by an impressive community of commensals, that has profound effects on the immune funtions. The relationship between gut microbiota and the immune system is one of reciprocity: commensals have important contribution in nutrient processing and education of the immune system and conversely, the immune system, particularly gut-associated lymphoid tissues plays a key role in shaping the repertoire of gut microbiota
Negative co-receptors and ligands by Rafi Ahmed( )

12 editions published between 2011 and 2013 in English and held by 489 WorldCat member libraries worldwide

Adaptive immune responses serve as a key defense mechanism for the control of infections in vertebrates. Immune responses must be of sufficient strength to contain invading pathogens, antigen specific responses require regulatory mechanisms to ensure termination or downmodulation to avoid excessive damage to the host tissue. For both branches of the adaptive immune system, regulatory molecules i.e. coreceptors and ligands have been identified that control the signaling cascades initiated by engagement of the T cell and B cell antigen receptors. This book describes biological functions as well as molecular mechanisms of these molecules. Fc Receptor-Like molecules (FCRL) that have garnered increasing interest due to their differential patterns of lymphocyte expression and potential involvement in the pathogenesis of autoimmune disorders, immunodeficiency and lymphoid malignancies in humans. Programmed cell death-1 (PD-1) delivers negative signals upon interaction with its two ligands, PD-L1 or PD-L2. The biological significance of PD-1 and its ligand suggest the therapeutic potential of manipulation of PD-1 pathway against various human diseases. TIM-3 acts as a negative regulator of Th1/Tc1 cell function by triggering cell death upon interaction with its ligand, galectin-9. This negative regulatory function of TIM-3 has now been expanded to include its involvement in establishing and/or maintaining a state of T cell dysfunction or 'exhaustion' observed in chronic viral diseases. The Ly49 receptors, which are expressed in a stochastic manner on subsets of murine Natural Killer (NK) cells, T cells, and other cells, are encoded by the Klra gene family and include receptors with either inhibitory or activating function. Most of the inhibitory Ly49 receptors recognize polymorphic epitopes on major histocompatibility complex (MHC) class I proteins as ligands. Fc-receptors for IgG (FcgRs) are widely expressed on innate immune effector cells in mediating the protective function of IgG. This book discusses how the interaction of these different ligands to classical and novel Fcg-receptors influences the immune response and which strategies microorganisms have developed to prevent them. The host derived cytokine IL-10 is a key player in the establishment and perpetuation of viral persistence.¡ This book covers the role of IL-10 in viral persistence and explores the exciting prospect of therapeutically blocking IL-10 to increase antiviral immunity and vaccine efficacy. TGF-ß inhibits the proliferation of T cells as well as cytokine production via Foxp3-dependent and independent mechanisms. Recent studies suggest that Smad2 as well as Smad3 play essential roles in Foxp3 induction and cytokine suppression, whereas Th17 differentiation is promoted via the Smad-independent pathway. Mutual suppression of signaling between TGF-ß and inflammatory cytokines has been shown to be necessary for the balance of immunity and tolerance
Evolution of life : fossils, molecules, and culture by Syozo Osawa( Book )

8 editions published in 1991 in English and held by 299 WorldCat member libraries worldwide

Nearly thirty million species of organisms are believed to now live on Earth. In addition to accumulating evidence from classical biology, paleontology and earth science, the recent progress of molecular biology has provided new insights into understanding how present-day organisms have evolved with such tremendous diversity. Molecular biological studies show us that all living forms, including E. coli and human beings, derive from a single ancestor that emerged some 4 billion years ago on Earth. This volume aims to discuss the motifs of organismic evolution from the viewpoints of biogeo-interactions and diversification of the genetic systems. Based on these fundamental understandings, the last section of this volume is devoted to human evolution that includes phylogeny of man as well as evolution of human culture. Such comprehensive discussion will give us a synthesized view of the evolution of life, that is undoubtedly one of the most important problems not only for science but also for human culture in general
Aid for immunoglobulin diversity by Frederick W Alt( )

6 editions published in 2007 in English and held by 207 WorldCat member libraries worldwide

Advances in Immunology, a long established and highly respected serial, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research
Viruses and Nanotechnology by Max D Cooper( )

1 edition published in 2008 in English and held by 27 WorldCat member libraries worldwide

Viral nanoparticles (VNPs) serve as excellent nanobuilding blocks for materials design and fabrication. The main advantages are their nanometer-range size, the propensity to self-assemble into monodisperse nanoparticles of discrete shape and size, the high degree of symmetry and polyvalency, and the relative ease of producing large quantities
Malaria : drugs, disease, and post-genomic biology by R. W Compans( )

8 editions published in 2005 in English and Undetermined and held by 21 WorldCat member libraries worldwide

This volume brings some of the worlds best investigators to describe recent advances in both the scientific and clinical aspects of malaria, and bridges between the two. The opening chapters discuss antimalarials and resistance to them in Africa and Asia. Then there are reviews of the different clinical manifestations of malaria, ranging from uncomplicated infections to severe disease and its complications. This section is followed by detailed reviews of what the new 'omics' offer to investigators of Plasmodium biology and is completed by descriptions of advances in understanding the biology of Plasmodium in the mosquito. If this volume attracts new students and provokes existing investigators to explore new directions, then it will have achieved much of what it has set out to do
Immunobiology of natural killer cell receptors by R. W Compans( )

5 editions published in 2006 in English and Undetermined and held by 15 WorldCat member libraries worldwide

Natural Killer (NK) cells are large granular lymphocytes of the innate immune system and are involved in direct innate immune reactions against viruses, bacteria, and other triggers of pathology. This book focuses on the nature of recognition events by NK cells and address how these events are integrated to trigger these effector functions
Genomu ga kataru seimeizo : Gendaijin no tame no saishin seimei kagaku nyumon by Tasuku Honjo( Book )

2 editions published in 2013 in Japanese and held by 7 WorldCat member libraries worldwide

Koredake wa shitte okitai idenshi igaku no kiso chishiki( Book )

3 editions published in 2003 in Japanese and held by 6 WorldCat member libraries worldwide

Inochi towa nanika : Kōfuku genomu yamai by Tasuku Honjo( Book )

2 editions published in 2009 in Japanese and held by 5 WorldCat member libraries worldwide

CD4+CD25+ regulatory T cells : origin, function, and therapeutic potential by R. W Compans( )

5 editions published in 2005 in English and Undetermined and held by 4 WorldCat member libraries worldwide

The vertebrate immune system defends the organism against invading pathogens while at the same time being self-tolerant to the body's own constituents thus preserving its integrity. Multiple mechanisms act in concert to ensure self-tolerance. Additional tolerance mechanisms, collectively referred to as dominant tolerance is by now firmly established. It will offer new conceptual insights and hopefully new tools for the sucessful treatment of autoimmune diseases, improved cancer immunotherapy and transplant survival
Men'eki to ketsueki no kagaku( Book )

1 edition published in 1999 in Japanese and held by 4 WorldCat member libraries worldwide

Gut-Associated lymphoid tissues ; with ... 5 tables( Book )

1 edition published in 2006 in English and held by 4 WorldCat member libraries worldwide

Idenshi ga kataru seimeizō( Book )

3 editions published in 1986 in Japanese and held by 4 WorldCat member libraries worldwide

Lesser Known Large dsDNA Viruses by Max D Cooper( Book )

2 editions published in 2008 in English and held by 4 WorldCat member libraries worldwide

Several large dsDNA-containing viruses such as poxviruses (smallpox) and herpes viruses are well known among the scientific community, as well as the general populace, because they cause human diseases. The large dsDNA insect-infecting baculoviruses are also well known in the scientific community because they are used both as biological control agents and as protein expression systems. However, there are other large dsDNA-containing viruses, including the giant 1.2 Mb mimivirus, which are less well known despite the fact that all of them play important roles in every day life. Seven of these v
Quasispecies : concept and implications for virology by Esteban Domingo( )

1 edition published in 2006 in English and held by 4 WorldCat member libraries worldwide

Continuous genetic variation and selection of virus subpopulations in the course of RNA virus replications are intimately related to viral disease mechanisms. The central topics of this volume are the origins of the quasispecies concept, and the implications of quasispecies dynamics for viral populations
Men'ekikei ninshiki bunka zōshoku( Book )

2 editions published in 1989 in Japanese and held by 3 WorldCat member libraries worldwide

 
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WorldCat IdentitiesRelated Identities
Immunoglobulin genes
Covers
Molecular biology of B cellsGut-associated lymphoid tissuesNegative co-receptors and ligandsAid for immunoglobulin diversityMalaria : drugs, disease, and post-genomic biologyImmunobiology of natural killer cell receptorsCD4+CD25+ regulatory T cells : origin, function, and therapeutic potentialGut-Associated lymphoid tissues ; with ... 5 tablesLesser Known Large dsDNA Viruses
Alternative Names
Honjo, Daseuku 1942-

Honjō, T.

Honjo, T. 1942-

Honjo T. (Tasuku)

Honjo, T. (Tasuku), 1942-

Honjō, Tasuku

Honjo, Tasuku 1942-

Honzyō, T. (Tasuku)

Tasuko Honjo

Tasuku Hondžo japonský imunolog

Tasuku Honjo

Tasuku Honjo dokter asal Jepang

Tasuku Honjo immunologiste japonais

Tasuku Honjo immunologo giapponese

Tasuku Honjo investigador japonés

Tasuku Honjo Japanese immunologist

Tasuku Honjo japanischer Immunologe

Tasuku Honjo Japans immunoloog

Tasuku Honjo japansk immunolog

Tasuku Honjo japoński immunolog, laureat Nagrody Nobla

Тасуку Хонджо

Тасуку Хонџо јапонски имунолог и нобеловец

Хондзё, Тасуку

Хондзё, Тасуку японский учёный-иммунолог

Хондзьо Тасуку японський учений-імунолог, нобелівський лауреат (2018)

טסוקו הונג'ו

تاسوكو هونجو عالم مناعة ياباني

تاسوکو هونجو

तासुकू हॉन्जो

টাচুকু হঞ্জ'

তাসুকু হনজো

தசுக்கு ஓஞ்சோ

തസൂക്കു ഹോൻജോ

본서우 1942-

혼조 다스쿠 일본의 면역학자

혼조 타스쿠 1942-

혼죠 다스크 1942-

ホンジョ, タスク

ホンジョ, タスク 1942-

本庶, 佑 1942-

本庶佑 1942-

本庶佑 日本の医師、研究者

Languages
English (108)

Japanese (13)