WorldCat Identities


Works: 676 works in 777 publications in 1 language and 789 library holdings
Classifications: BF778, 153.66
Publication Timeline
Most widely held works by MINNESOTA UNIV MINNEAPOLIS
Research and development in the field of high altitude plastic balloons - vol. xii( Book )

6 editions published between 1952 and 1955 in English and held by 5 WorldCat member libraries worldwide

Contents: Rasonde charts, time-altitude charts, trajectories; Time-temperature charts; Theoretical meteorological analysis: Part A. Characteristics of stratospheric flow; Part B: Winds in the upper troposphere and lower stratosphere
An atlas of semantic profiles for 360 words by James J Jenkins( Book )

1 edition published in 1957 in English and held by 4 WorldCat member libraries worldwide

Molecular Regulation of Immune Recognition Molecule Expression by Breast Cancer Cells( Book )

4 editions published between 1998 and 2001 in English and held by 2 WorldCat member libraries worldwide

New strategies to improve the outcome of patients with metastatic breast cancer must address the issue of residual chemotherapy-resistant cells. Immunotherapy offers the potential of manipulating effector cells to generate an enhanced anti-tumor effect. From initial data demonstrating that natural killer (NK) cells require interleukin-2 (IL-2) in order to lyse breast cancer targets, we have now explored the mechanisms which mediate tumor killing
Biotherapy of Breast Cancer with EGF-Genistein( Book )

6 editions published between 1997 and 2000 in English and held by 2 WorldCat member libraries worldwide

Our proposed research plan involves laboratory studies using a SCID mouse model of human metastatic breast cancer, as well as in vitro MTT(3- 4,5- DIMETHYLTHIAZOL-2-YL -2,5-diphenyl tetrazolium bromide) and colony assays, using established breast cancer cell lines, to examine the potency and toxicity of various EGE-Genistein conjugates. In an effort to generate more effective conjugates, we have employed a variety of crosslinking agents and photolysis conditions. Furthermore, we have established HPLC(high performance liquid chromatography) procedures to characterize and isolate the EGF components of the reaction mixture. We have also conjugated EGF to other small molecules which by themselves have been shown to possess anti-cancer activity. The knowledge gained from these studies is expected to lead to more effective biotherapy and combined biochemotherapy regimens for the treatment of breast cancer patients
Prediction of Aggressive Human Prostate Cancer by Cathepsin B( Book )

3 editions published between 2005 and 2008 in English and held by 1 WorldCat member library worldwide

I received approval of the DOD-HSRRB in April, 2005 and began the study shortly after receiving approval. We are enclosing copies of published and accepted papers in the Anticancer Research. These papers address parts of both Specific Aims outlined in the project. I submitted an abstract of our accepted paper, "Cathepsin B Expression Indicates that Prostate Cancer is Similar in African-American and Caucasian Men" to the Department of Defense Prostate cancer research program meeting: Innovative Minds in Prostate Cancer Today (IMPACT). Our abstract was selected and accepted for presentation on September 5-6 meetings in Atlanta, GA. This is significant achievement for our work that started in April 2005. Our paper, "Heterogeneity of Cathepsin B and Stefin A Expression in Gleason Pattern 3+3 (score 6) Prostate Cancer Needle Biopsies" was published in Anticancer Research 27: 1407-1414, 2007. We showed that small foci of Gleason pattern 3+3 (histological score 6) tumors in needle biopsies have heterogeneous cathepsin B and stefin A immunostaining. We have shown that score 6 tumors are heterogeneous and some of the tumors had micrometastases. We have suggested that stratification of these tumors by cathepsin B and stefin A in relation to clinical data may assist in identification of aggressive cancer and treatment selection
Development of a New Mouse Model to Study the Interactions of Obesity on the Development of Breast Cancer( Book )

3 editions published between 1998 and 1999 in English and held by 1 WorldCat member library worldwide

Breast cancer is the most frequently diagnosed cancer in women (1). One risk factor that has been proposed to play a role in the development of postmenopausal breast cancer is increased body weight and/or body mass index (BMI) (weight/height2). Several reviews of the literature have shown that both case-control and prospective studies support this conclusion (2,3). A recent study of Italian women concluded that overweight accounted for 10.2% of postmenopausal breast cancer cases (4). Other studies have implicated weight gain as a risk factor for breast cancer development (5-8). In spite of these reports, roles for body weight and weight gain in breast cancer development have not been supported by all studies. This may be partially explained by technical factors. For example, conflicting results from human studies might be due to inaccurate recalled body weight. Also, whether weights from before or after menopause are used appears to make a difference in the conclusions drawn (9). In addition to these problems, there are other confounding factors such as the influences of ethnic and social backgrounds, and the potential for interactions with other risk factors
Dietary Fat, Eicosanoids and Breast Cancer Risk( Book )

5 editions published between 2005 and 2009 in English and held by 1 WorldCat member library worldwide

Epidemiological and animal studies associate high levels of dietary fat with increased risk of sex hormone mediated cancer, such as breast cancer. A high intake of total fat and omega-6 fatty acids increases risk while omega-3 (n3) fatty acids are associated with risk reduction. Our proposal is testing the effect of dietary fat and fatty acids on sex hormone concentrations in post-menopausal women. The objectives are to evaluate 1) the effects of total fat and n3 intake on plasma and urinary sex hormone levels, 2) the relationship between plasma fatty acids and plasma and urinary sex hormones, and 3) the effects of total fat and n3 on the association between sex hormone concentrations and urinary prostaglandin E2 (PGE2). We are performing a randomized, Latin square-designed controlled feeding study testing High Fat, Low Fat, and Low Fat + n3 diets, each of 8 week duration. In order to determine the estrogenic effects of the diets, sex hormone endpoints will be measured reflecting availability, metabolism, and action. Plasma fatty acids fractions and urinary PGE2 will be measured to evaluate mechanistic effects. At present 48 women have been screened by telephone, 16 have been screened in the clinic and 12 are currently enrolled in the trial. Eight subjects have completed all aspects of the trial. Initial data analysis is being started this summer of the sex hormone samples. No data has yet been generated
Hyaluronan Tumor Cell Interactions in Prostate Cancer Growth and Survival( Book )

3 editions published between 2006 and 2009 in English and held by 1 WorldCat member library worldwide

Hyaluronan is a high molecular weight polyanionic polysaccharide that is increased in more advanced prostate cancers. Tumor cell interaction with this polysaccharide by specific receptors CD44 and RHAMM promote tumor growth, survival and invasion. Work during the last funding period have further defined the mechanism of action of each of these receptors. Studies show that extracellular RHAMM acts a co-receptor for CD44, and the combined action of this receptor complex leads to sustained activation of the ERK 1,2 signal transduction pathway leading to enhance motility and produce patterns of gene transcription that are associated with invasion. Synthetic peptides have also been identified that can bind hyaluronan and inhibit the binding of this polysaccharide to its cognate receptors. These peptides inhibit tumor growth both in vitro and in vivo and the residues important for the activity of the peptides are being defined using nuclear magnetic resonance (NMR). Small molecule libraries that contain compounds which may mimic these peptides are also being interrogated for the ability to inhibit hyaluronan binding to RHAMM and CD44 and to inhibit tumor growth. The goal is to develop new therapeutic strategies for patients with invasive prostate cancer
Epitaxial Iron Films( Book )

3 editions published between 1988 and 1991 in English and held by 1 WorldCat member library worldwide

The growth properties and magnetic properties of iron films grown by molecular beam epitaxy were studied. The iron film growth was first studied by growing iron on iron whiskers. This work and previous work determined the growth parameters for nearly dislocation free growth. This information was then used to grow iron films on Gallium Arsenide/Indium Arsenide alloy substrates. As determined by electron diffraction, layer by layer growth was observed when the iron films were grown. The magnetic properties of the iron films were found to be dependent up on the substrate surface morphology and lattice constant. In particular the coercivity of epitaxed iron film was found to vary by roughly a factor of four when grown on different surface morphologies and substrate lattice spacings. Other research focused on the magnetotransport and magnetooptic properties of the iron film and the effects of the substrate lattice properties on them
Regulation of the Multidrug Resistance-Associated Protein Gene by Estrogen( Book )

4 editions published between 1998 and 2001 in English and held by 1 WorldCat member library worldwide

An observation was made that the mRNAs for two clones, #41 and #44, were rapidly repressed by estrogen in chick oviduct. Clone #44 shared sequence homology with members of the multidrug resistance-associated protein (mrp) gene family. This raised the question of whether the multidrug resistance (mdr) phenotype in breast cancer may be in part due to the loss of repression of MRP expression by estrogen when antiestrogens are administered. The goals of this last year were to complete the identification of clone #41 and to publish a manuscript describing the work completed thus far. The latter goal has been accomplished and is included as Appendix A. The results with MRP1 have considerable significance in light of two recent reports that indicate that MRP mRNA is highly expressed in primary breast cancers, particularly those with poor prognosis. Our observations raise the possibility that one or more of the selective estrogen receptor modulators (SERMs) may be useful in treating those resistant cancers. While we do not as yet have the complete sequence of clone #41, about 1,000 new bp of sequence has been obtained. The 1300 bp in hand encodes a predicted protein with about 96% identity to two human and one mouse partial clones of the kelch superfamily
Breast Cancer Following Pediatric Hodgkin's Disease: Risk Factors and Intervention( Book )

4 editions published between 1998 and 2000 in English and held by 1 WorldCat member library worldwide

Analysis of a cohort of 1380 survivors of childhood Hodgkin's disease (HD) has shown a 75-fold increased risk of breast cancer, with the cumulative probability of developing breast cancer approaching 35% by 40 years of age among the female survivors of HD. We hypothesized that patients with HD who develop breast cancer have a genetic susceptibility to do so. The purpose of this proposal was to identify a subpopulation among the survivors of HD, at an increased risk for developing breast cancer, and to institute intervention in the form of active screening and possibly chemoprevention. Construction of pedigrees of patients with secondary breast cancer has failed to reveal excess of cancer among family members. We also planned to identify somatic and/or germline mutations in candidate genes known to be associated with breast cancer, including p53, BRCA1 and ATM. Four of the six breast cancer samples examined so far, contained mutations in exons 5-9 of the p53 gene. We plan to institute a surveillance protocol in HD patients at high risk of developing secondary breast cancer, to look at the efficacy of mammography as a screening tool in early detection of breast cancer and in reducing mortality
A Novel Approach to Increase Breast Cancer Chemosensitivity: Disruption of the Anti-Apoptotic Function of Translation Factor eIF4E( )

3 editions published between 2000 and 2003 in English and held by 0 WorldCat member libraries worldwide

In this report we present data in support of Aim 1 of our project. Utilizing human breast carcinoma cell lines as an in vitro model for naturally occurring malignancy, we demonstrated that both the apoptotic and translational machinery are activated in five breast carcinoma cell lines. Suppression of cap-dependent translation by pharmacological inhibitors of 4E-BPl phosphorylation or by ectopic expression of 4E-BPl stimulated apoptosis and abrogated chemoresistance in fibroblasts and breast carcinoma cells expressing oncogenic Ras. Activation of apoptosis by translational inhibitors paralleled their ability to repress the cap-dependent translation apparatus. These results show that the integrity of the cap-dependent translational apparatus is critically important for breast cancer cell chemoresistance. They also suggest that targeted disruption of the cap-binding complex can be used as a novel approach for blocking malignant progression in breast carcinoma and other tumors whose growth depends on activation of cap-dependent translation
Role of IRS-1 Phosphorylation in IGF-1 and IL-4 Signaling in Breast Cancer( )

3 editions published between 2001 and 2003 in English and held by 0 WorldCat member libraries worldwide

Insulin-like growth factor-I (IGF-I) is a potent mitogen for breast cancer cells. Binding of IGF-I to its receptor results in activation of the receptor which then phosphorylates the adaptor protein insulin receptor substrate-1 (IRS-1). Our laboratory has shown that phosphorylation of IRS-1 by IGF-I caused enhanced ubiquitin dependent proteasomal degradation of IRS-1. In contrast, interleukin-4 (IL-4) which also phosphorylates IRS-1 does not enhance degradation of IRS-1. The goal of this project is to understand if phosphorylation of different residues on IRS-1 is responsible for the proliferative response mediated by IGF-I compared to the death signal mediated by IL-4. To identify the residues two-dimensional electrophoresis (2D PAGE) of IRS-1 was undertaken. The first task was to isolate phosphorylated P32-labeled IRS-1 which was successfully completed. Two-dimensional electrophoresis of IRS-1 which is a 180 kDa protein has encountered several technical difficulties. So far, IRS-1 has not been detected either by subjecting immunoprecipitated P32-labeled IRS-1 to 2D electrophoresis or immunoblotting lysates with IRS-1 antibody after 2D PAGE. In addition, we have not been able to see proteins above 100 kDa on 2D gels either by silver staining or radioisotope detection of P32 or S35 labeled lysates of MCF-7 cells
Dietary Phytoestrogens and Prostate Cancer Prevention( )

4 editions published between 2003 and 2007 in English and held by 0 WorldCat member libraries worldwide

The main objective of this project is to evaluate the effects of soy phytoestrogen consumption on reproductive hormones and prostate tissue markers of cell proliferation and androgen action in men at high risk of prostate cancer. The hypothesis is that alteration of endogenous hormones is a mechanism by which soy phytoestrogens prevent prostate cancer. A randomized parallel arm study will be performed, in which 90 men at high risk of prostate cancer will be randomized to receive one of three dietary supplements for six months: (1) soy powder containing phytoestrogens; (2) phytoestrogen-free soy powder; or (3) phytoestrogen-free milk powder. Urine and blood will be collected at 0, 3 and 6 months, for evaluation of prostate cancer risk factors, including serum hormones (testosterone, dihydrotestosterone, androstenedione, dehydroepiandrosterone, estradiol, estrone, 3alpha:, 17Beta-androstanediol glucuronide, sex hormone binding globulin) and prostate specific antigen, as well as urinary estrogen and phytoestrogen metabolites. Before and after the intervention, prostate biops will be performed to evaluate prostate tissue expression of apoptosis (TUNEL assay, Bax, Bcl-2), proliferation (Ki67, PCNA and androgen receptor density. At this point, seven subjects have begun the feeding study and biological samples have been collected, processed and stored
Breast Cancer Resistance to Cyclophosphamide and Other Oxazaphosphorines( )

4 editions published between 1995 and 1998 in English and held by 0 WorldCat member libraries worldwide

Cyclophospharnide is the most widely used drug in the treatment of breast cancer. Unfortunately, emergence of drug- resistant tumor cell populations limits its usefulness. Class-I and class-3 aldehyde dehydrogenases (ALDH-1 and ALDH- 3, respectively) have been shown to catalyze the detoxification of cyclophosphamide and other oxazaphosphorines. Predictably, then, relatively elevated levels of ALDH-I and ALDH-3 have been shown to account for resistance to these agents in several cultured breast and other tumor cell models. It follows that cellular resistance to these agents on the part of clinical breast cancers could be due to overexpression of ALDH-1 and/or ALDH-3. Our finding that elevated levels of ALDH-1 and ALDH-3 are present in some primary and metastatic breast tumor tissues supports this notion. Although nearly identical, tumor cell ALDH-3 appears to be different from normal cell ALDH-3. A tumor-specific ALDH-3 would have diagnostic potential. Tumor cell ALDH-3 was found to be more sensitive to inhibition by each of five chlorpropamide analogs than was normal cell ALDH-3 suggesting that selective sensitization of tumor cells to cyclophosphamide and other oxazaphosphorines may be possible when tumor cell insensitivity to these drugs is due to high levels of ALDH-3. Xenobiotics that are abundantly present in the diet/environment, e.g., methylcholanthrene and catechol, rapidly, coordinately and reversibly induced ALDH-3 and other drug metabolizing enzymes in cultured breast land 9ther cancer cell models, thus, rapidly effecting reversible multienzyme-mediated multidrug resistance/collateral sensitivity to cyclophosphamide and certain other anticancer drugs
Mechanisms of Alcohol Induced Effects on Cellular Cholesterol Dynamics( )

4 editions published between 2001 and 2004 in English and held by 0 WorldCat member libraries worldwide

The focus of this grant is on mechanisms of alcohol induced disruption of cellular cholesterol transport and distribution. Alcohol at concentrations observed in problem drinkers and alcoholics (for example an individual consuming either 6 beers, or 6 one oz shots of whiskey, or 6 glasses of wine) has a profound and multifaceted effect on cellular regulation of cholesterol. Ethanol significantly inhibited cholesterol efflux from human aortic smooth muscle cells to HDL. The Golgi complex that is important in regulation of cholesterol efflux is a target of ethanol as revealed by confocal microscopy. Preliminary data indicate that acute and chronic effects of ethanol on cholesterol efflux from human aortic smooth muscle cells to HDL have opposite effects. LDL-mediated cholesterol uptake is stimulated by ethanol. Alcohol results in more cholesterol being taken into cells and less cholesterol being removed from cells. These findings have several important implications. Cholesterol content in cells of problem drinkers and alcoholics may be elevated as compared to control subjects and such a difference would not be detected by routine clinical assays for cholesterol. Cholesterol is essential for the normal function of cells. Alcohol-induced changes in cell cholesterol content could have profound pathophysiological consequences on cell function
A Model DOD Systems Approach for Tobacco Cessation( )

5 editions published between 2001 and 2007 in English and held by 0 WorldCat member libraries worldwide

While tobacco use in the military costs over $584 million per year in health related expenses, 29.9% of our enlisted forces continue to smoke (Helyer, Brehm, & Penno, 1995; Bray, Sanchez, Ornstein, et al., 1999) The primary objective of this study is to evaluate the efficacy of a community initiative on smoking prevalence among active duty personnel and TRICARE Prime beneficiaries. Sixteen military installations (four each from the Air Force, Army, marines, and navy) will be assigned to either an intervention or delayed intervention condition. At the end of this second year of the study research accomplishments include implementing, monitoring and modifying the intervention at Air Force sites, refining the survey instrument, creating all of the necessary components of the community campaign, sourcing, identifying and random assignment of the Navy and Marine sites, obtaining preliminary lRB approval from the Bethesda Navy lRB, and consulting with Army personnel on identifying Army bases that will volunteer to participate in the study
Prevention of Breast Cancer in IGFBP( )

3 editions published between 2001 and 2004 in English and held by 0 WorldCat member libraries worldwide

In this proposal, we hypothesize that inhibition of IGF action by IGFBP-1 will prevent breast cancer in a SV40 Tag transgenic model of breast cancer. We will test this hypothesis with two specific aims: 1) to inhibit-IGF action at the mammary epithelial cell by creating transgenic mice that express IGFBP-1 under the control of the whey acidic protein (WAP) promoter and 2) to test the ability of IGFBP-1 to suppress tumorigenesis by mating these animals with C3/Tag transgenic mice. To achieve these goals, we have created the expression vector, injected the construct into mice, and now have our first generation of mice. Of the animals we have analyzed, approximately 25% have the transgene. We are currently in the process of mating the F1 generation and determining if we have achieved IGFBP-1 expression in the mammary gland
Molecular Determinants of Cellular Sensitivity to Flavopiridol an Anti-Cell Signaling Anticancer Agent( )

3 editions published between 2001 and 2003 in English and held by 0 WorldCat member libraries worldwide

Flavopiridol (FP) is an investigational new drug currently in Phase II clinical trials for the treatment of solid tumors (Senderowicz et al., 1998). The precise mechanism of action of this compound is unknown, however, it is known to inhibit several members of the cyclin-dependent protein kinase family, and to induce cell death (Senderowicz, 1999, Schrump, et al., 1998, Bible and Kaufmann, 1996). The objective of this proposal is to gain insight into the molecular mechanism(s) whereby human tumor cells become resistant to FP. To gain greater insight into this question, a FP-resistant clone was generated from the human MCF-7 breast adenocarcinoma cell line. This clone was obtained by exposing growing cultures of MCF-7 cells to increasing concentrations of FP over a several month period of time. The resulting clone, named MCF-71F, has an IC50 for FP that is 24-fold lower than that of the parental MCF-7 cell line cell line from which it was derived. Specifically, the experiments described in this proposal are designed to identify the molecular basis for FP resistance in MCF-7/FP cells. We have evaluated, or are in the process of evaluating cellular levels of known FP targets, i.e. cyclin-dependent protein kinases in MCF-7/FP and MCF-7 cells. In addition, we have begun to examine the relative resistance of these cells to a number of drugs. Finally, we have been examining the relative expression levels of a number of drug efflux pumps in these cell lines. It is anticipated that FP or FP-like molecules will ultimately assume a place in the modern cancer chemotherapeutic armamentarium. Thus, insight gained into the molecular basis of FP drug resistance in MCF-7/FP cells may ultimately prove beneficial in the design of second or third generation FP analogues. It is also conceivable that this information may aid in the development of chemotherapy strategies to minimize the emergence of clinical resistance to these agents
Hyaluronan Biosynthesis in Prostate Carcinoma( )

3 editions published between 2003 and 2007 in English and held by 0 WorldCat member libraries worldwide

Despite advances in the diagnosis and treatment of prostate cancer in the last several years, metastasis represents the major cause of frustration and failure in the successful treatment of prostate cancer patients. Hyaluronan (HA) is polymeric anionic carbohydrate that is elevated within primary prostate tumors, most notably within the tumor-associated stroma. We have demonstrated that increased HA synthesis by human prostate carcinoma cells correlates with metastatic potential. This increased synthesis results from the elevated expression of specific hyaluronan synthases (HAS) in the tumor cells. Metastatic prostate carcinoma cells exhibiting high levels of HAS assemble and retain a pericellular HA matrix on their cell surfaces. We have used vectors to stably express constructs encoding antisense for HAS enzymes to study the importance of elevated hyaluronan synthesis in prostate carcinoma adhesion, growth and tumor formation. The studies outlined in this annual report document our observations that support an important role for hyaluronan in prostate tumor progression
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English (74)