WorldCat Identities


Works: 580 works in 680 publications in 1 language and 670 library holdings
Publication Timeline
Most widely held works by STANFORD UNIV CA
Asynchronous Design for Parallel Processing Architectures( Book )

7 editions published between 1989 and 1993 in English and held by 5 WorldCat member libraries worldwide

The objective of this research is to provide an interconnect design synthesis methodology which facilitates a modular design approach without compromising the global performance. The main tasks of this effort will be the development of the theory for optimal interconnect synthesis from a high-level specification, with emphasis on testability and fault-tolerance asynchronous interface among concurrent computing hardware objects, and the application of this design methodology to physical implementations of parallel processing systems. (KR)
Determination of the Structural Basis of Antibody Diversity Using NMR( Book )

4 editions published between 1988 and 1990 in English and held by 3 WorldCat member libraries worldwide

The combination of Nuclear Magnetic Resonance (NMR) spectroscopy, recombinant DNA techniques and theoretical semiempirical model building appears to be a powerful approach to the protein engineering of antibody combining sites, for the ultimate production of antibodies having desired specificities and functions. In the past year we have sequenced the cDNA's of 12 monoclonal anti spin label antibodies, have constructed a working model for one of these antibodies (M. Levitt), and have carried out a number of NMR experiments that have tested this model and have provided kinetic data on hapten antibody binding. In the next year crucial tests of this model, our NMR assignments and this general approach to protein engineering will be made by transfection/expression experimentation involving specific mutations of the antibody genes for the antibodies ANO1-AN12. Keywords: Recombinant DNA, Monoclonal antibodies
The Contract Net Protocol: High-Level Communication and Control in a Distributed Problem Solver by Reid G Smith( Book )

1 edition published in 1980 in English and held by 3 WorldCat member libraries worldwide

Genes Involved in DNA Double-Strand Break Repair: Implications for Breast Cancer( Book )

5 editions published between 1996 and 1998 in English and held by 2 WorldCat member libraries worldwide

Significance of double-strand breaks DNA double-strand breaks (DSBs) may be the most disruptive form of DNA damage. If left unrepaired, they lead to broken chromosomes and cell death. If repaired improperly, they can lead to chromosome translocations and cancer. Humans are at risk for DSB 5 from exogenous agents. The paradigm agent, ionizing radiation (IR), is present in the environment from the decay of radon and radon daughters, which accumulate to high levels in homes built on land reclaimed from mining, leading to increased cancer risk. Ionizing radiation can cause cancers in many tissues, with breast tissue being particularly sensitive (6, 12). Mice exposed to IR show a dose-dependent increase in breast cancer (59). Women exposed by the atomic bombs detonated over Hiroshima and Nagasaki (42) or treated with radiation for post partum mastitis (51) had increased risks for breast cancer
Isolation of a Receptor for WNT/Wingless Growth Factors( Book )

7 editions published between 1995 and 1999 in English and held by 2 WorldCat member libraries worldwide

The work done in this grant aims at elucidating the function of the Wnt signaling molecules in cancer. Wnt proteins are secreted and play important growth controlling roles, in particular in the mammary gland. They can act as oncogenes in mouse mammary tumors. The work is specifically aimed at identifying a receptor for Wnt proteins. The isolation of a receptor is critical to our understanding of normal growth control of the mammary gland. Using genetic and biochemical approaches we wish to identify and to clone the receptor for a Wnt gene product in Drosophila, called wingless. The receptor will be characterized and using the receptor gene, we will subsequently clone mammalian Wnt receptors by homology
Interactions Between Vitamin D and Breast Cancer( Book )

3 editions published between 2008 and 2010 in English and held by 2 WorldCat member libraries worldwide

This is a study of vitamin D therapy of women with breast cancer (BCa) in the neoadjuvant period. The goal of the study is to determine whether vitamin D changes the expression of important target genes that may predict BCa prognosis. Thus far we have recruited 48 patients of the planned total of 50 subjects. Several subjects are not included in this report since they have not yet had their surgery or we have not yet received their biopsy or surgical specimens. These data will eventually be added to the current analysis. The women were stratified according to their circulating vitamin D status (serum 25(OH)D concentration) receiving daily doses of vitamin D3 of 2000 IU, 4000 IU or 6000 IU or no therapy. We have analyzed the biopsy samples (pre-intervention) and compared results with the surgical specimens (post-intervention) to determine whether dietary vitamin D supplements can regulate the gene expression profile in the BCa cells and normal cells. The goal is to determine whether vitamin D deficiency is associated with a poor prognosis gene profile and whether vitamin D intervention converts the profile toward a more normal profile of gene expression, perhaps representing a better prognosis
Processes and Knowledge in Designing Instruction by James G Greeno( Book )

2 editions published in 1990 in English and held by 2 WorldCat member libraries worldwide

This report presents results obtained in a study of problem solving in the domain of instructional design. Participants were eight teacher trainees who studied a computer-based tutorial about a fictitious vehicle, the VST2000. The next day, each participant designed instructional materials of two general kinds: about how to operate the vehicle, and about general principles of energy storage, extraction, conversion, transportation, and use that the vehicle illustrates. A scheme for coding the protocols was developed, considering three aspects of the process of design problem solving: subproblems, types of knowledge used, and problem-solving operators. Data from the eight protocols are presented, showing variations among designers in the relative amounts of work on subproblems and their use of knowledge types and operators, and patterns in these features over time in their problem-solving activity. The variables used in this analysis are considered as general features of P.T.O. design problem solving and are discussed in relation to several published analyses in a variety of domains. Keywords: Information processing theory
Paclitaxel (Taxol) Resistance in Breast Cancer Cells( Book )

4 editions published between 1995 and 1997 in English and held by 1 WorldCat member library worldwide

Because breast cancer MDA 435 and MCF-7 cells do not grow clonally at single cell densities, we studied mechanisms of resistance to paclitaxel (Taxol) in single-step selected clones of human sarcoma cells
Cooling and Trapping of Atoms and Particles( Book )

3 editions published between 1997 and 2001 in English and held by 1 WorldCat member library worldwide

We showed that it is possible to cool atoms in a one dimensional optical lattice using to a novel degenerate sideband cooling technique. This method was then extended to a three dimension optical lattice. With this method, we are able capture all the atoms in a MOT and directly cool them to the photon recoil temperature at phase space densities of 1/500 using low powered (20 mW) diode laser beams. This represents a 2 1/2 order of magnitude increase in phase space density over the best form of grey optical molasses
Prostate Dose Escalation by a Innovative Inverse Planning-Driven IMRT( Book )

4 editions published between 2005 and 2008 in English and held by 1 WorldCat member library worldwide

The goal of this project is to develop innovative inverse planning techniques for prostate radiation therapy. In the last funding period significant progress has been made toward the goal of the project. In the past funding year, the PI group has continued to advance prostate radiation therapy techniques. A few important milestones have been achieved toward the goal of the project. These include: (i) Proposed a novel total-variation regularization based inverse planning technique for prostate IMRT; (ii) Applied compressed sensing concept to IMRT and IMAT inverse planning and established a multi-objective optimization framework; (iii) Developed a voxel-specific penalty scheme for TRV-based inverse planning; (iv) Established a cine-EPID image retrospective dose reconstruction in IMRT dose delivery for adaptive planning and IMRT dose verification. These works are both timely and important and should lead to widespread impact on prostate cancer management
The Development and Evaluation of an Innovative Internet-Based Breast Cancer Psychosocial Intervention( Book )

3 editions published between 2000 and 2002 in English and held by 1 WorldCat member library worldwide

The purpose of this project is to develop and evaluate an Internet-based psychosocial intervention for women with primary breast cancer. During this funding period (10/1/00 to 9/31/01), the following tasks were completed: (1) 72 women were randomized to usual care (wait-list control group) or psychosocial support group. Three twelve-week Internet-based psychosocial groups (8-12 members per group) were facilitated with intervention group participants and two groups were facilitated with wait-list control group participants; (2) preliminary analyses on data collected from participants were completed; (3) preliminary text analyses of the support group messages were completed. Results: The initial analyses found that in comparison to wait-list control group participants, intervention group participants significantly reduced their depression, post-traumatic stress, and general stress scores. Significance: Women with primary breast cancer are able to participate in Internet-based psychosocial interventions and receive substantial benefits from their participation. The next phase of the project will be to complete enrollment into the intervention, analyze completed outcome data, and continue our exploration of ways to capture and understand the discourse that occurred in the groups
Regulation of Estrogen Receptor Transcription in Breast Carcinoma( )

3 editions published between 1995 and 1998 in English and held by 0 WorldCat member libraries worldwide

In this study, we performed a functional mapping of the Estrogen Receptor (ER) promoter region and found a region in the 5' untranslated leader sequence that controlled ER transcription in ER-positive breast carcinoma cell lines. This region contained two binding sites for a transcription factor, Estrogen Receptor Factor-1 (ERF-1). ERF-1 was identified by gel shift assay and was present in ER-positive breast and endometrial carcinoma cells, but absent in ER-negative cell lines, thus inferring a role for ERF-1 in the regulation of ER transcription in breast carcinoma. Mutational analysis of the ERF-1 binding site showed that ERF-1 binding was correlated with transcriptional activity. ERF-1 was purified from MCF7 breast carcinoma cells using ion-exchange and DNA affinity chromatography and the cDNA was isolated from a MCF7 expression cDNA library. ERF-1 was identified as AP2gamma, a member of the AP2 transcription factor family. When binding specificity of ERF-1 was compared to AP2alpha using PCR-Assisted Binding Site selection and competitive gel shift assay, it was found that the two proteins recognized the same DNA sequence. Cotransfection of AP2alpha or AP2gamma with an ER promoter reporter construct demonstrated that activation of the ER promoter is dependent upon cell type
Vitamin D Treatment of Prostate Cancer: The Inhibitory Role of IGFBP-3( )

3 editions published between 2004 and 2006 in English and held by 0 WorldCat member libraries worldwide

Calcitriol plays a critical role in maintaining mineral homeostasis but also exhibits antiproliferative activity in many cancers. We have shown that the antiproliferative actions of calcitriol in the LNCaP human prostate cancer (PCa) cell is mediated in large part by induction of insulin-like growth factor binding protein-3 (IGFBP-3). The purpose of this study was to determine the molecular mechanism involved in calcitriol regulation of IGFBP-3 and to identify the putative vitamin D response element (VDRE) in the IOFBP-3 promoter. We cloned 6 kb of the IGFBP-3 promoter and demonstrated its responsiveness to calcitriol in transactivation assays. Computer analysis identified a putative VDRE between -32961/-3282 that is similar to other known VDREs. In gel shift assays the vitamin D receptor (VDR) showed strong calcitriol-dependent binding to this putative VDRE. ChIP assay demonstrated that calcitriol recruited the VDR/RXR heterodimer to the VDRE site. In transactivation as says the VDRE promoter was induced 2-fold by calcitriol. Mutations created in the VDRE resulted in a loss of IGFBP-3 induction confirming the critical VDRE sequence. In conclusion, we have identified a functional VDRE in the distal region of the human IGFBP-3 promoter that directly mediates the action of calcitriol
Energy- and Intensity-Modulated Electron Beam for Breast Cancer Treatment( )

3 editions published between 1999 and 2003 in English and held by 0 WorldCat member libraries worldwide

This project is aimed at exploring energy- and intensity-modulated radiotherapy (EIMRT) to deliver dose distributions that closely match the target volume and minimize the dose to critical normal structures. The scope includes (I) to characterize electron beams from Helium-filled accelerators for EIMRT, (2) to develop optimization algorithms for EIMRT using these electron beams, (3) to verify these optimized dose distributions using the Monte Carlo simulation technique, and (4) to compare the optimized dose plans obtained by EIMRT with conventional treatment plans and those obtained by photon intensity- modulated radiotherapy (IMRT). During the first year research, we have performed accurate Monte Carlo simulations of the electron beams in He-filled accelerators. Our results demonstrated that electron beams could be modulated to deliver superior dose distributions for EIMRT. We have implemented practical source models for clinical application and beam commissioning. Different dose algorithms have been compared for "Inverse treatment planning" beamlet calculations. The results confirmed that the Monte Carlo method is needed to generate the dose distributions for EIMRT. Further studies will be performed to verify the dose plans for realistic patients. The outcome will determine whether EIMRT offers a significant advantage over conventional photon/electron treatment and over photon IMRT
A Low-Cost, High Quality MRI Breast Scanner Using Prepolarization( )

3 editions published between 1999 and 2001 in English and held by 0 WorldCat member libraries worldwide

Magnetic Resonance Imaging (MRI) has been shown to be more sensitive and equally specific when compared to x-ray mammography for detecting breast cancer. MRI is non-invasive, completely non-toxic, and requires no uncomfortable breast compression. But an x-ray mammogram costs about $100 whereas an MRI study costs about $1500. The exam cost is related to the scanners manufacturing cost (about $400,000) and sale price (about $1 to $3 Million). X-ray mammography units cost about one tenth of the cost of an MRI scanner. Our objective is to tailor a new concept in MRI called Prepolarized MRI (PMRI) for low-cost MR mammography. PMRI substitutes two inexpensive pulsed magnets for the expensive superconducting magnet. We believe that a high-quality MRI breast scanner using prepolarization could be manufactured for less than $45,000. This project could potentially make MRI as affordable as x-ray mammography. We have made considerable progress this year in realizing a working PMRI scanner. Indeed, we recently obtained our first in vivo human wrist images with our 0.4 T prototype scanner. While the image quality of our prototype scanner is not yet of clinical quality, the results are very promising considering the total cost of the magnets was less than $30,000
The Role of Vitamin D Stimulation of Mullerian Inhibiting Substance (MIS) in Prostate Cancer Therapy( )

3 editions published between 2006 and 2008 in English and held by 0 WorldCat member libraries worldwide

We propose that MIS regulation may be an important element contributing to the ability of 1,25- dihydroxyvitamin D3 (calcitriol) to inhibit the growth and progression of prostate cancer cells. We have shown that calcitriol acts by several pathways to inhibit the growth of prostate cancer cells [1-5]. In the current studies we show that calcitriol also stimulates the expression of MIS in a standard human prostate cancer cell line, LNCaP. We further show that the up-regulation of MIS expression is mediated directly by calcitriol binding to the vitamin d receptor (VDR) and the complex subsequently interacting with a vitamin D regulatory element (VDRE) in the MIS gene promoter
Cells with Unique Properties in Prostate Cancer-Associated Stroma are Mesenchvmal Stem Cells( )

2 editions published in 2007 in English and held by 0 WorldCat member libraries worldwide

The importance of tumor stroma in prostate cancer development and progression has been recognized through its stimulating effects on cancer cell growth, migration and angiogenesis. Our hypothesis was that the prostate cancer stroma is derived, at least in part, from mesenchymal stem cells (MSCs) that are proliferative, multipotent and self-renewing. Our objective was to demonstrate that cancer-derived stromal cells have characteristics of mesenchymal stem cells. Comparing primary cultures of stromal cells from cancer versus normal tissues, we observed (a) differential gene expression profiles, (b) increased expression of autotaxin, a motility factor, (c) increased expression of the MSC-associated antigen CD90, and (d) increased expression of transforming growth factor-beta, associated with tumor promotion, in CD90-positive cells. Many of these properties are consistent with a mesenchymal stem cell phenotype of prostate cancer-associated stroma, supporting our hypothesis
Oral Contraceptives and Bone Health in Female Runners( )

7 editions published between 1999 and 2007 in English and held by 0 WorldCat member libraries worldwide

This is a two-year randomized trial of the effects of oral contraceptives on bone mass and stress fractures incidence among 151 female competitive distance runners in the age range 18-25 years. The Coordinating Center is at Stanford University and bone mass is being measured at five sites: Massachusetts General Hospital, University of California Los Angeles, University of Michigan, Stanford University/Palo Alto VA Medical Center, and Helen Hayes Hospital in West Haverstraw, NY. Athletes were recruited mostly from the areas around these five clinical sites. Over the five clinical sites, 151 runners were randomized, and follow-up continues. Follow-up will be completed in October 2005, and final results of the study should be available in early 2006
Development of Methodology to Maintain Primary Cultures of Normal and Malignant Human Prostatic Epithelial Cell In Vivo( )

3 editions published between 2005 and 2008 in English and held by 0 WorldCat member libraries worldwide

Our objective was to develop a realistic preclinical model of prostate cancer by developing methodology that supports the survival, growth and differentiation of primary cultures of prostate cells in mice. Use of a novel substrate, "OptiCell" membranes, for implantation, choice of the renal capsule for implantation, and selection of stem-like cells for implantation did not resolve the unwanted development of squamous differentiation. Therefore, we investigated the implantation of precision-cut tissue sections. These tissue slices can be maintained in culture, and our initial results suggest that they also survive and maintain structure and function under the renal capsule. We will continue to develop tissue slices as a novel in vitro in vivo experimental model of prostate cancer
Do Capacitively Coupled Electric Fields Accelerate Tibial Stress Fracture Healing( )

3 editions published between 2002 and 2005 in English and held by 0 WorldCat member libraries worldwide

A convenience sample based on availability of tibial stress fracture cases at local Sports Medicine Clinics was selected. The study was designed to determine if electric field stimulation accelerates the healing of tibial stress fracture and whether there are gender effects. Only posteromedial mid to distal third and proximal medial tibial condylar stress fractures were investigated. Four imaging examinations were performed at diagnosis (radiographs, bone scan, MRI and CT). All subjects were treated identically in a double blind fashion using active or passive electric field stimulator devices (active units apply a sinusoidal wave of 3-6 V, 60 KHz, 5-10 mA), worn 15-20 hours per day, and other standardized rehabilitation treatments, until healed but not longer than 6 months. Subjects were considered healed when hopping on the affected limb was longer painful. A second MRI examination was performed for follow-up comparison. A grading system is being developed for each of the diagnostic methods and the ability of the MRI grading system is being assessed to predict time to recovery
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English (73)