Most widely held works by Adolph Januszkiewicz
Early Systemic Biomarkers of Acute Lung Injury: Application of Multiplex Proteomic Array Technology ( Book )
1 edition published in 2008 in English and held by 1 library worldwide
The primary objectives of the present study were: 1) to set up a non-invasive animal model of 'inhalation injury', to monitor early changes in levels of pro-inflammatory cytokines in breath condensates of live rats, to delineate early biomarkers of pulmonary inflammation; 2) to further investigate the role of specific proinflammatory mediator(s) in acute lung inflammation/injury following exposure to toxic fire gases and/or BOP shockwave-mediated blunt trauma; 3) to monitor changes in various pro-inflammatory cytokines/chemokines in small volumes of biological samples (10-50 microliters), by utilizing a highly sensitive Proteome Array-based Multiplex ELISA; 4) to identify early systemic 'biomarkers' of acute lung injury/toxicity, for development of much-needed strategies/tools for effective therapeutic intervention and lung-health assessment of active-duty U.S. solders deployed around the world. The primary goal of this study was to identify early 'biomarkers' of acute pulmonary inflammation, as an predictive indicator of acute lung toxicity and/or injury, following exposure of rats to a brief high-dose of NO2, a militarily relevant toxic fire gas and a product of high temperature combustion.
An Introductory Characterization of a Combat-Casualty-Care Relevant Swine Model of Closed Head Injury Resulting from Exposure to Explosive Blast ( Book )
1 edition published in 2009 in English and held by 1 library worldwide
Explosive blast has been extensively used as a tactical weapon in Operation Iraqi Freedom (OIF) and more recently in Operation Enduring Freedom (OEF). The polytraumatic nature of blast injuries is evidence of their effectiveness, and brain injury is a frequent and debilitating form of this trauma. In-theater clinical observations of brain-injured casualties have shown that edema, intracranial hemorrhage, and vasospasm are the most salient pathophysiological characteristics of blast injury to the brain. Unfortunately, little is known about exactly how an explosion produces these sequelae as well as others that are less well documented. Consequently, the principal objective of the current report is to present a swine model of explosive blast injury to the brain. This model was developed during Phase I of the DARPA (Defense Advanced Research Projects Agency) PREVENT (Preventing Violent Explosive Neurotrauma) blast research program. A second objective is to present data that illustrate the capabilities of this model to study the proximal biomechanical causes and the resulting pathophysiological, biochemical, neuropathological, and neurological consequences of explosive blast injury to the swine brain. In the concluding section of this article, the advantages and limitations of the model are considered, explosive and air overpressure models are compared, and the physical properties of an explosion are identified that potentially contributed to the in-theater closed head injuries resulting from explosions of improvised explosive devices (IEDs).
Sequestration of Blood Plasma Iron as a Marker of Systemic Response to the Blast Lung Injury: Assessment with Electron Paramagnetic Resonance (EPR) Spectroscopy ( Book )
1 edition published in 2004 in English and held by 1 library worldwide