WorldCat Identities

McKee, Jr., Kelly T.

Overview
Works: 3 works in 3 publications in 1 language and 3 library holdings
Publication Timeline
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Most widely held works by Jr., Kelly T McKee
Outbreak of Hemorrhagic Fever with Renal Syndrome among U.S. Marines in Korea( Book )

1 edition published in 1990 in English and held by 1 WorldCat member library worldwide

Hemorrhagic fever with renal syndrome (HFRS) is a rodent-borne zoonosis endemic across much of Europe and Asia that is responsible for considerable human morbidity and mortality. A spectrum of clinical severity is recognized with HFRS, ranging from asymptomatic or mild infection to fulminant hemorrhagic fever and death. The etiologic agents are a group of at least 5 antigenically distinguishable viruses comprising the Hantavirus genus of the large virus family Bunyaviridae. These viruses establish chronic infections in certain species of rodents and are transmitted to man primarily via aerosols or fomites from contaminated excreta. Geographic (and, to a large degree, clinical) variation is determined by the distribution of the rodent species associated with each distinct virus
Phase 1 Study of Safety and Immunogenicity of an Escherichia coli-Derived Recombinant Protective Antigen (rPA) Vaccine to Prevent Anthrax in Adults( )

1 edition published in 2010 in English and held by 0 WorldCat member libraries worldwide

Background: The fatal disease caused by Bacillus anthracis is preventable with a prophylactic vaccine. The currently available anthrax vaccine requires a lengthy immunization schedule, and simpler and more immunogenic options for protection against anthrax are a priority for development. In this report we describe a phase I clinical trial testing the safety and immunogenicity of an anthrax vaccine using recombinant Escherichia coli-derived, B. anthracis protective antigen (rPA). Methodology/Principal Findings: A total of 73 healthy adults ages 18-40 were enrolled and 67 received 2 injections separated by 4 weeks of either buffered saline placebo, or rPA formulated with or without 704 mg/ml AlhydrogelH adjuvant in increasing doses (5, 25, 50, 100 mg) of rPA. Participants were followed for one year and safety and immunologic data were assessed. Tenderness and warmth were the most common post-injection site reactions. No serious adverse events related to the vaccine were observed. The most robust humoral immune responses were observed in subjects receiving 50 mg of rPA formulated with AlhydrogelH with a geometric mean concentration of anti-rPA IgG antibodies of 283 mg/ml and a toxin neutralizing geometric 50% reciprocal geometric mean titer of 1061. The highest lymphoproliferative peak cellular response (median Lymphocyte Stimulation Index of 29) was observed in the group receiving 25 mg AlhydrogelH-formulated rPA. Conclusions/Significance: The vaccine was safe, well tolerated and stimulated a robust humoral and cellular response after two doses
An Assessment of Health Status Among Medical Research Volunteers Who Served in the Project Whitecoat Program at Fort Detrick, Maryland( )

1 edition published in 2005 in English and held by 0 WorldCat member libraries worldwide

Between 1954 and 1973, more than 2000 men entering military service as conscientious objectors participated in Project Whitecoat as medical research volunteers for the Army's biological warfare defense program. An assessment of self-reported, current health status among 358 "exposed" individuals and 164 unexposed control subjects found no conclusive evidence that receipt of investigational agents was related to adverse health outcomes. No differences in current overall health, current exercise levels, self-reported symptoms, and self-reported medical conditions were seen between the study groups. Possible associations were seen between exposure to antibiotics or other biological agents and self-reported asthma (13.0% vs. 2.4%, relative risk [RR] = 6.00, 95% confidence interval [CI] = 1.03-34.90, p = 0.050), as well as between receipt of tularemia vaccine(s) and self-reported asthma (13.3% vs. 2.4%, RR = 6.15, 95% CI = 1.03-36.70, p = 0.049) and increased frequency/severity of headaches (35.6% vs. 18.3%, RR = 2.46, 95% CI = 0.99-6.15, p = 0.074). However, the size of the population under study was insufficient to assert with confidence that these statistical associations are real
 
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