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Integrated strategies for drug discovery using mass spectrometry
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Integrated strategies for drug discovery using mass spectrometry

Author: Mike S Lee
Publisher: Hoboken, N.J. : Wiley-Interscience, ©2005.
Edition/Format: Book : EnglishView all editions and formats
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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Mike S Lee
ISBN: 047146127X 9780471461272
OCLC Number: 57579301
Description: xvii, 550 p. : ill. ; 24 cm.
Contents: Miniaturized formats for efficient liquid chromatography mass spectrometry-based proteomics and therapeutic development / Gary A. Valaskovic and Neil Kelleher -- Mass-spectrometry-based drug screening assays for early phases in drug discovery / Marshall M. Siegel -- ESI-FTICR as a high throughput drug discovery platform / Kristin A. Sannes-Lowery ... [et al.] -- Mass spectrometry-based proteomic approaches for disease diagnosis and biomarker discovery / Thomas P. Conrads ... [et al.] -- Metabonomic applications in toxicity screening and disease diagnosis / John P. Shockcor and Elaine Holmes -- The central role of mass spectrometry in natural products discovery / Jeffrey R. Gilbert ... [et al.]. Application of mass spectrometry to compound library generation, analysis, and management / Xueheng Cheng and Jill Hochlowski -- A combinatorial process for drug discovery / David S. Wagner ... [et al.] -- Application of technological advances in biotransformation studies / Carmen L. Fernández-Metzler, Raju Subramanian and Richard C. King -- Applications of mass spectrometry for the characterization of reactive metabolites of drugs in discovery / Jim Wang ... [et al.] -- Advances in high throughput quantitative drug discovery bioanalysis / Bradley L. Ackermann, Michael J. Berna and Anthony T. Murphy -- New strategies for the implementation and support of bioanalysis in a drug metabolism environment / Walter A. Korfmacher -- An integrated LC-MS strategy for preclinical candidate optimization / Jonathan L. Josephs and Mark Sanders -- New approaches for method development and purification in lead optimization / Yining Zhao and David J. Semin -- High throughput metabolic and physicochemical property analysis / Edward H. Kerns and Li Di -- Organ perfusion and mass spectrometry / C. Gerald Curtis ... [et al.] -- Sample preparation for drug discovery bioanalysis / David A. Wells -- Automation / John D. Laycock and Thomas Hartmann.
Responsibility: [edited by] Mike S. Lee.
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