| Contents: |
I. Fundamental considerations -- 1. Overview of ocular drug delivery -- 2. Membrane transport processes in the eye -- 3. General considerations in ocular drug delivery -- II. Transport models in ocular drug delivery -- 4. Ocular drug transfer following systemic drug administration -- 5. Ocular pharmocokinetics and pharmacodynamics -- 6. Mathematical modeling of drug distribution in the vitreous humor -- 7. Anterior segment microdialysis -- 8. Posterior segment microdialysis -- III. Drug delivery systems -- A. Conventional systems -- 9. Ocular penetration enhancers -- 10. Corneal collagen shields for ocular drug delivery -- 11. The noncorneal route in ocular drug delivery -- 12. Ocular iontophoresis -- 13. Mucoadhesive polymers in ophthalmic drug delivery -- 14. Microparticles and nanoparticles in ocular drug delivery -- 15. Dendrimers: an innovative and enhanced ocular drug delivery system -- B. Delivery of macromolecular therapeutic agents -- 16. Ocular delivery and therapeutics of proteins and peptides -- 17. Retinal disease models for development of drug and gene therapies -- 18. New experimental therapeutic approaches for degenerative diseases of the retina -- 19. Gene, oligonucleotide, and ribozyme therapy in the eye -- IV. Regulatory aspects -- 20. Regulatory considerations -- 21. Patent considerations -- Index. |
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