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| Document Type: | Book |
|---|---|
| All Authors / Contributors: |
Andrzej Mackiewicz; Irving Kushner; Heinz Baumann |
| ISBN: | 0849369134 9780849369131 |
| OCLC Number: | 27384414 |
| Description: | 686 p. : ill. ; 27 cm. |
| Contents: | Introduction to the acute phase response -- Acute phase response: an overview -- Negative acute phase proteins -- Extrahepatic synthesis of acute phase proteins -- Major acute phase proteins: their structure and possible function in acute phase response -- Structure and function of human C-reactive protein -- SAA lipoprotein family -- [alpha]₁-acid glycoprotein: structure and possible functions in the acute phase response -- Proteinase inhibitors: an overview of their structure and possible function in the acute phase -- [alpha]₁-antitrypsin: structure, function, physiology -- Fibrinogen: a multifunctional acute phase protein -- Haptoglobin: retrospectives and perspectives -- Acute phase complement proteins -- Rat [alpha]₂-macroglobulin and related [alpha]-macroglobulins in the acute phase response -- Rat thiostatin: structure and possible function in the acute phase response -- Systems in which to study regulation of acute phase proteins -- Experimental systems for studying hepatic acute phase response -- Cytokines and hormones implicated in acute phase protein regulation. (cont) Biological perspectives of cytokine and hormone networks -- Interleukin-6 -- Interleukin-11: molecular biology, biological activities, and possible signaling pathways -- Role of oncostatin M in the acute phase response -- Tumor necrosis factor -- Interleukin-6 receptor -- Regulation of acute phase protein gene expression -- Regulation of C-reactive protein, haptoglobin, and hemopexin gene expression -- Serum amyloid A gene regulation -- Regulation of [alpha]₁-acid glycoprotein genes and relationship to other type 1 acute phase plasma proteins -- Transcriptional regulation of the human C3 gene -- Regulation of the [alpha]₂-macroglobulin gene -- Regulation of the rat [alpha]₂-macroglobulin gene by interleukin-6 and leukemia inhibitory factor -- Regulation of the rat thiostatin gene -- Cytokine regulation of the mouse SAA gene family -- Signal transduction of cytokines in hepatocytes -- Signal transduction mechanisms regulating cytokine-mediated induction of acute phase proteins -- Post-transcriptional processes -- Intracellular maturation of acute phase proteins. Control of glycosylation alterations of acute phase glycoproteins -- Post-translational regulation of C-reactive protein secretion -- Clinical applications -- Cytokine measurements in disease -- Diagnostic and prognostic value of interleukin-6 measurements in human disease -- Measurement of acute phase proteins as disease markers -- Glycoforms of [alpha]₁-acid glycoprotein as disease markers. |
| Responsibility: | edited by Andrzej Mackiewicz, Irving Kushner, Heinz Baumann. |
| More information: |
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