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Therapeutic oligonucleotides
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Therapeutic oligonucleotides

Author: Jens Kurreck
Publisher: Cambridge : RSC Pub., ©2008.
Series: RSC biomolecular sciences.
Edition/Format: Book : EnglishView all editions and formats
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Document Type: Book
All Authors / Contributors: Jens Kurreck
ISBN: 9780854041169 0854041168
OCLC Number: 237326966
Description: xvii, 343 p. : ill. (some col.) ; 24 cm.
Contents: The role of backbone modifications in oligonucleotide-based strategies -- Genasense (G3139) : an antisense Bcl-2 oligodeoxyribonucleotide with substantial clinical activity and a complex mechanism of action -- Antisense morpholino oligomers and their peptide conjugates -- Peptide-peptide nucleic acid conjugates for modulation of gene expression -- Locked nucleic acid: properties and therapeutic aspects -- Immune stimulatory oligonucleotides -- Decoy oligodeoxynucleotides to treat inflammatory diseases -- AS1411 : development of an anticancer aptamer -- Spiegelmer NOX-E36 for renal diseases -- Strategies for the delivery of oligonucleotides in vivo -- Lipid-mediated in vivo delivery of small interfering RNAs -- Vector-mediated and viral delivery of short hairpin RNAs -- Development of an RNAi-based gene therapy against HIV-1 -- RNA based therapies for treatment of HIV infection.
Series Title: RSC biomolecular sciences.
Responsibility: edited by Jens Kurreck.

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