RT Web Page DB /z-wcorg/ DS http://worldcat.org ID 795742377 LA English UL http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=449958 T1 Absorption and drug development : solubility, permeability, and charge state A1 Avdeef, Alex., YR 2012 SN 9781118285961 1118285964 9781621982265 1621982262 1280589345 9781280589348 9781118286036 1118286030 AB BExplains how to perform and analyze the results of the latest physicochemical methods/b/ With this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compound's pharmaceutical properties and their effects on drug absorption. The book emphasizes oral absorption, explaining all the physicochemical methods used today to analyze drug candidates. Moreover, the author provides expert guidance to help readers analyze the results of their studies in order to select the most promising drug candidates./ This iSecond Edition/i has been thoroughly updated and revised, incorporating all the latest research findings, methods, and resources, including:/ ulli Descriptions and applications of new PAMPA models, drawing on more than thirty papers published by the author's research group/ /lili Two new chapters examining permeability and Caco-2/MDCK and permeability and the blood-brain barrier/ /lili Expanded information and methods to support pKa determination/ /lili New examples explaining the treatment of practically insoluble test compounds/ /lili Additional case studies demonstrating the use of the latest physicochemical techniques/ /lili New, revised, and expanded database tables throughout the book/ /li/ul Well over 200 drawings help readers better understand difficult concepts and provide a visual guide to complex procedures. In addition, over 800 references serve as a gateway to the primary literature in the field, facilitating further research into all the topics covered in the book./ This iSecond Edition/i is recommended as a reference for researchers in pharmaceutical R & D as well as in agrochemical, environmental, and other related areas of research. It is also recommended as a supplemental text for graduate courses in pharmaceutics.