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Accurate results in the clinical laboratory : a guide to error detection and correction

Author: Amitava Dasgupta; Jorge L Sepulveda
Publisher: London : Elsevier, ©2013.
Edition/Format:   Print book : EnglishView all editions and formats
Database:WorldCat
Summary:

Suitable for both clinicians and laboratory scientists, presented in the form of tables and charts for easy reference, this title addresses interference issues in all laboratory tests, including  Read more...

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Document Type: Book
All Authors / Contributors: Amitava Dasgupta; Jorge L Sepulveda
ISBN: 9780124157835 0124157831
OCLC Number: 774488005
Description: xiii, 368 pages : illustrations ; 28 cm
Contents: Machine generated contents note: 1. Variation, Errors, and Quality in the Clinical Laboratory / Jorge Sepulveda --
Introduction --
Errors in the Clinical Laboratory --
Quality Improvement in the Clinical Laboratory --
Conclusions --
References --
2. Effect of Age, Gender, Diet, Exercise, and Ethnicity on Laboratory Test Results / Octavia M. Peck Palmer --
Introduction --
Effects of Age-Related Changes on Clinical Laboratory --
Test Results --
Effects of Gender-Related Changes on Clinical Laboratory --
Test Results --
Effects of Diet on Clinical Laboratory Test Results --
Effects of Nutraceuticals on Clinical Laboratory Test Results --
Effects of Exercise on Clinical Laboratory Test Results --
Effects of Ethnicity/Race on Clinical Laboratory Test Results --
Conclusions --
References --
3. Effect of Patient Preparation, Specimen Collection, Anticoagulants, and Preservatives on Laboratory Test Results / Christopher Naugler --
Introduction. Contents note continued: Biological Rhythms and Laboratory Test Results --
Issues of Patient Preparation --
Differences Between Whole Blood, Plasma, and Serum Specimens for Clinical Laboratory Analysis --
Different Anticoagulants and Preservatives, Order of Draw, Problems with Gel Interference in Serum Separator Tubes, and Short Draws --
Order of Draw of Various Blood Collection Tubes --
Collection Sites; Differences Between Arterial, Capillary, and Venous Blood Samples; and Problems with Collections from Catheters and Intravenous Lines --
Urine Collection, Timing, and Techniques --
Conclusions --
References --
4. Sample Processing and Specimen Misidentification Issues / Amy L. Pyle --
Introduction --
Transportation --
The Effects of Centrifugation on Laboratory Results --
Effect of Storage Conditions on Laboratory Results --
Effect of Cross-Contamination of Specimens on Laboratory Results --
Consequences of Specimen Misidentification on Laboratory Testing --
Conclusions. Contents note continued: References --
5. Hemolysis, Lipemia, and High Bilirubin: Effect on Laboratory Tests / Steven C. Kazmierczak --
Introduction --
Effect of Hemolysis on Laboratory Tests --
Lipemia --
Icterus --
Methods for Evaluating the Effect of Endogenous Interfering Substances on Laboratory Tests --
Conclusions --
References --
6. Immunoassay Design and Mechanisms of Interferences / Pradip Datta --
Introduction --
Immunoassay Methods and Assay Principles --
Specimen Types Used in Immunoassays --
Examples of Immunoassays --
Pitfalls in Immunoassays --
How to Detect and Correct Heterophilic Antibody Interferences --
Conclusions --
References --
7. Effect of Herbal Remedies on Clinical Laboratory Tests / Amitava Dasgupta --
Introduction --
Elevated Liver Function Test Due to Use of Herbal Supplements Herbal Supplements --
Causing Kidney Damage --
Herbal Remedies and Hypoglycemia --
Licorice and Hypokalemia --
Kelp and Abnormal Thyroid Function Tests. Contents note continued: Drug---Herb Interaction and Unexpected Drug Levels in Routine Drug Monitoring --
Adulteration of Herbal Supplements with Western Drugs --
Conclusions --
References --
8. Challenges in Routine Clinical Chemistry Testing: Analysis of Small Molecules / Jorge Sepulveda --
Introduction --
Creatinine Analysis --
Urea Analysis --
Ammonia Assay --
Uric Acid Analysis --
Glucose Analysis --
Analysis of Electrolytes --
Blood Gases Analysis --
Lactate Analysis --
Bilirubin Analysis --
Lipid Profiles Analysis --
Conclusions --
References --
9. Challenges in Routine Clinical Chemistry Analysis: Proteins and Enzymes / Jorge Sepulveda --
Introduction --
Albumin and Total Protein --
Alanine and Aspartate Aminotransferases Analysis --
[gamma]-Glutamyl Transferase and Alkaline Phosphatase Analysis --
Amylase and Lipase Analysis --
Lactate Dehydrogenase Analysis --
Creatine Kinase Analysis --
Cardiac Troponin Analysis --
B-Type Natriuretic Peptide Analysis --
Conclusions. Contents note continued: References --
10. Sources of Inaccuracy in Biochemical Genetics Testing / Michael J. Bennett --
Introduction --
Analysis of Amino Acids --
Analysis of Organic Acids --
Analysis of Acylcarnitines --
Conclusions --
References --
11. Challenges in Endocrinology Testing / William E. Winter --
Introduction --
Challenges in Testing of Hormones Secreted by Pituitary --
Challenges in Measuring Human Chorionic Gonadotropin --
Challenges in Thyroid Function Tests --
Adrenal Function Tests --
Testing of Parathyroid Function --
Gonadal and Reproductive Interferences --
Prostate --
Testing for Insulin-Like Growth Factor --
Measurement of Other Hormones Including Insulin --
Prenatal Testing --
Conclusions --
References --
12. Pitfalls in Tumor Markers Testing / Amer Wahed --
Introduction --
Clinical Uses of Tumor Markers --
Prostate-Specific Antigen --
CA-125 --
[alpha]-Fetal Protein --
Carcinoembryonic Antigen --
CA-19-9 --
[beta]2-Microglobulin. Contents note continued: Human Chorionic Gonadotropin --
Interference from Heterophilic Antibodies in Laboratory Testing of Tumor Markers --
Analysis of Less Frequently Assayed Tumor Markers --
Conclusions --
References --
13. Issues of Interferences in Therapeutic Drug Monitoring / Kamisha L. Johnson-Davis --
Introduction --
Sources of Pre-Analytical Interferences in TDM --
Sources of Analytical Interferences in TDM --
Mechanisms of Analytical Interferences in TDM --
Chromatography and Mass Spectrometry --
Examples of Interferences that Affect TDM --
Conclusions --
References --
14. Limitations of Drugs of Abuse Testing / Amitava Dasgupta --
Introduction --
Drugs of Abuse Testing: Medical Versus Legal --
Drugs Tested in Drugs of Abuse Testing Protocols --
Drug Testing Methodologies --
Challenges in Testing for Amphetamines --
Challenges in Testing of Cocaine Metabolite --
Challenges in Testing for Opiates --
Challenges in Testing for Marijuana Metabolites. Contents note continued: Challenges in Testing for Phencyclidine --
Challenges in Testing for Benzodiazepines --
Challenges in Determining Other Drugs by Immunoassays --
Adulterants and Drugs of Abuse Testing --
Other Drugs not Detected by Routine Toxicology Screens --
Conclusions --
References --
15. Challenges in Confirmation Testing for Drugs of Abuse / Larry A. Broussard --
Introduction: Factors to Consider when Interpreting Drug Testing Results --
Confirmation Testing Process --
Confirmation of Amphetamines --
Confirmation of Cocaine Metabolite Benzoylecgonine --
Confirmation of Opiates --
Confirmation of Marijuana Metabolite --
Confirmation of Phencyclidine --
Confirmation of Benzodiazepines --
Confirmation of Barbiturates --
Specimen Validity Testing --
Conclusions --
References --
16. Alcohol Determination Using Automated Analyzers: Limitations and Pitfalls / Sheila Dawling --
Introduction --
Development of Laboratory Methods for Ethanol Measurement. Contents note continued: Current Automated Methodologies --
Performance of Automated Ethanol Assays --
Problems with Current Methodologies --
Strategies for Removing Interferences --
Further Case Studies --
Future Directions --
Conclusions --
References --
17. Pre-Analytical Issues and Interferences in Transfusion Medicine Tests / Elena Nedelcu --
Introduction --
Basics of Immunohematology --
Methodology used for Immunohematology Tests --
Pre-Transfusion Evaluation --
Interferences in Basic Transfusion Medicine Tests --
Case Studies --
Conclusions --
References --
18. Issues with Immunology and Serology Testing / Semyon Risin --
Introduction --
Challenges in Hemoglobinopathy Detection --
Detection of Monoclonal Proteins --
Challenges in HIV Testing --
Hepatitis Testing --
Anti-Nuclear Antibodies --
Conclusions --
References --
19. Sources of Errors in Hematology and Coagulation Testing / Amer Wahed --
Introduction --
Errors in Hemoglobin Measurement and RBC Count. Contents note continued: Errors in MCV and Related Measurements --
Errors in WBC Counts and WBC Differential Counts --
Errors in Platelet Count --
Errors in Specific Hematology Testing --
Coagulation Testing --
Errors in PT and aPTT Measurements --
Errors in Thrombin Time Measurement --
Platelet Aggregation Testing with Lipemic, Hemolyzed, or Thrombocytopenic Samples --
Challenges in Anticoagulants and Lupus Anticoagulant Tests --
Case Studies --
Conclusions --
References --
20. Challenges in Clinical Microbiology Testing / Laura Chandler --
Introduction --
Issues with Pre-Analytical Errors --
Analytical Errors in the Microbiology Laboratory --
Post-Analytical or Reporting Errors --
Error Prevention, Detection, and Monitoring --
Conclusions --
References --
21. Sources of Errors in Molecular Testing / Laura Chandler --
Introduction --
Principles of Commonly Used Methods for Molecular Diagnostics --
Principles of Nucleic Acid Isolation. Contents note continued: Pre-Analytical Considerations in Molecular Testing --
Interferences in Molecular Diagnostics: False-Negative Results in Molecular Assays --
Interferences in Molecular Testing: False-Positive Test Results in Molecular Assays --
Sources of Errors in DNA Microarray Testing --
Quality Management --
Conclusions --
References --
22. Problems in Pharmacogenomics Testing / Elaine Lyon --
Introduction --
Method Descriptions --
Applications of Pharmacogenetics Testings --
Case Studies --
Conclusions --
References.
Responsibility: edited by Amitava Dasgupta, Jorge L. Sepulveda.

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"Dasgupta and Sepulveda offer clinicians and laboratory scientists a guide to error detection and correction in the clinical laboratory that addresses sources of errors in analytical methods and Read more...

 
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   schema:description "Contents note continued: Challenges in Testing for Phencyclidine -- Challenges in Testing for Benzodiazepines -- Challenges in Determining Other Drugs by Immunoassays -- Adulterants and Drugs of Abuse Testing -- Other Drugs not Detected by Routine Toxicology Screens -- Conclusions -- References -- 15. Challenges in Confirmation Testing for Drugs of Abuse / Larry A. Broussard -- Introduction: Factors to Consider when Interpreting Drug Testing Results -- Confirmation Testing Process -- Confirmation of Amphetamines -- Confirmation of Cocaine Metabolite Benzoylecgonine -- Confirmation of Opiates -- Confirmation of Marijuana Metabolite -- Confirmation of Phencyclidine -- Confirmation of Benzodiazepines -- Confirmation of Barbiturates -- Specimen Validity Testing -- Conclusions -- References -- 16. Alcohol Determination Using Automated Analyzers: Limitations and Pitfalls / Sheila Dawling -- Introduction -- Development of Laboratory Methods for Ethanol Measurement."@en ;
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   schema:description "Contents note continued: Drug---Herb Interaction and Unexpected Drug Levels in Routine Drug Monitoring -- Adulteration of Herbal Supplements with Western Drugs -- Conclusions -- References -- 8. Challenges in Routine Clinical Chemistry Testing: Analysis of Small Molecules / Jorge Sepulveda -- Introduction -- Creatinine Analysis -- Urea Analysis -- Ammonia Assay -- Uric Acid Analysis -- Glucose Analysis -- Analysis of Electrolytes -- Blood Gases Analysis -- Lactate Analysis -- Bilirubin Analysis -- Lipid Profiles Analysis -- Conclusions -- References -- 9. Challenges in Routine Clinical Chemistry Analysis: Proteins and Enzymes / Jorge Sepulveda -- Introduction -- Albumin and Total Protein -- Alanine and Aspartate Aminotransferases Analysis -- [gamma]-Glutamyl Transferase and Alkaline Phosphatase Analysis -- Amylase and Lipase Analysis -- Lactate Dehydrogenase Analysis -- Creatine Kinase Analysis -- Cardiac Troponin Analysis -- B-Type Natriuretic Peptide Analysis -- Conclusions."@en ;
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   schema:description "Contents note continued: Pre-Analytical Considerations in Molecular Testing -- Interferences in Molecular Diagnostics: False-Negative Results in Molecular Assays -- Interferences in Molecular Testing: False-Positive Test Results in Molecular Assays -- Sources of Errors in DNA Microarray Testing -- Quality Management -- Conclusions -- References -- 22. Problems in Pharmacogenomics Testing / Elaine Lyon -- Introduction -- Method Descriptions -- Applications of Pharmacogenetics Testings -- Case Studies -- Conclusions -- References."@en ;
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   schema:description "Contents note continued: Biological Rhythms and Laboratory Test Results -- Issues of Patient Preparation -- Differences Between Whole Blood, Plasma, and Serum Specimens for Clinical Laboratory Analysis -- Different Anticoagulants and Preservatives, Order of Draw, Problems with Gel Interference in Serum Separator Tubes, and Short Draws -- Order of Draw of Various Blood Collection Tubes -- Collection Sites; Differences Between Arterial, Capillary, and Venous Blood Samples; and Problems with Collections from Catheters and Intravenous Lines -- Urine Collection, Timing, and Techniques -- Conclusions -- References -- 4. Sample Processing and Specimen Misidentification Issues / Amy L. Pyle -- Introduction -- Transportation -- The Effects of Centrifugation on Laboratory Results -- Effect of Storage Conditions on Laboratory Results -- Effect of Cross-Contamination of Specimens on Laboratory Results -- Consequences of Specimen Misidentification on Laboratory Testing -- Conclusions."@en ;
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