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Acetylthiocholinesterase Distribution in the Brain Stem of the Cat

Author: E Ramon-Moliner
Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg, 1972.
Series: Ergebnisse der Anatomie und Entwicklungsgeschichte / Advances in Anatomy, Embryology and Cell Biology / Revues d'anatomie et de morphologie expérimentale, 46/4; Ergebnisse der Anatomie und Entwicklungsgeschichte / Advances in Anatomy, Embryology and Cell Biology / Revues d'anatomie et de morphologie expérimentale, 46/4.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
The earliest studies on the regional distribution of acetylcholinesterase (AChE) within the central nervous system were based on the determination of the amount of CO liberated by homogenates of selected areas in the presence of an ester of 2 choline and a bicarbonate buffer. Using this biochemical approach, Burgen and Chipman (1951) were able to establish that acetylcholinesterase is not evenly distributed within  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: E Ramon-Moliner
ISBN: 9783642500558 3642500552 9783540060369 3540060367
OCLC Number: 858927924
Description: 1 online resource.
Contents: Materials and Methods --
Observations --
Motoneuronal Centers and Neighbor Regions --
Sensory Relay Centers and Neighbor Regions --
Specific Precerebellar Centers --
Other Well Outlined Centers --
Diffuse Reticular and Tegmental Regions --
Midline and Paramedian Nuclei of the Brain Stem --
Subependymal Regions --
Discussion --
1. Cholinergic Transmission in the Nervous System --
2. The Significance of a Positive AThChE Stain --
3. The Distribution of Acetylthiocholinesterase in the Brain Stem --
Summary --
Abbreviations --
References.
Series Title: Ergebnisse der Anatomie und Entwicklungsgeschichte / Advances in Anatomy, Embryology and Cell Biology / Revues d'anatomie et de morphologie expérimentale, 46/4; Ergebnisse der Anatomie und Entwicklungsgeschichte / Advances in Anatomy, Embryology and Cell Biology / Revues d'anatomie et de morphologie expérimentale, 46/4.
Responsibility: by E. Ramon-Moliner.

Abstract:

The earliest studies on the regional distribution of acetylcholinesterase (AChE) within the central nervous system were based on the determination of the amount of CO liberated by homogenates of selected areas in the presence of an ester of 2 choline and a bicarbonate buffer. Using this biochemical approach, Burgen and Chipman (1951) were able to establish that acetylcholinesterase is not evenly distributed within the central nervous system. They found that the cerebellum, the lateral geniculate body, and the striatum contained a high concentration of AChE. The high concentration of AChE in the striatum could be correlated with a higher rate of acetylcholine synthesis. However, this was not the case for the cerebellum, where acetylcholine synthesis was very low. Other in vitro studies have been aimed at establishing the regional distribution of the other two components of the cholinergic system, cholinacetylase (ChA) and acetylcholine (ACh). An equally asymetrical distribution for these substances has been established in vitro (MacIntosh, 1941 ; Feldberg and Mann, 1946; Feldberg and V ogt, 1948; MacIntosh and Oborin, 1953; Quastel, 1962; Mitchell, 1963; Krnjevic and Phillis, 1963; Aprison et al., 1964; McLennan, 1964; Cohen, 1956). The in vitro determination of acetylcholinesterase (Koelle, 1950; Burgen and Chipman, 1951; Giacobini, 1959; Bennett et al., 1966; Fahn and Cote, 1968; Miller et al., 1969) presents the advan tage of permitting the use of a substrate like ACh which is a normally occurring ester of choline so that the establishment of enzyme specificity is less questionable.

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