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Acute inhalation toxicity

Author: Organisation for Economic Co-operation and Development.
Publisher: [Paris] : OECD Publishing, 2009.
Series: OECD Guidelines for the Testing of Chemicals., Section 4,, Health Effects.
Edition/Format:   eBook : International government publication : EnglishView all editions and formats
Summary:
This method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation. The revised Test Guideline describes two studies: a traditional LC50 protocol and a Concentration x Time (C x t) protocol. It can be used to estimate a median lethal concentration (LC50), non-lethal threshold concentration (LC01) and slope, and  Read more...
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Details

Material Type: Government publication, International government publication, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Organisation for Economic Co-operation and Development.
ISBN: 9789264070608 9264070605
OCLC Number: 704443829
Description: 1 online resource (19 pages) : illustrations.
Series Title: OECD Guidelines for the Testing of Chemicals., Section 4,, Health Effects.
Other Titles: 403, adopted 7 September 2009
Responsibility: Organisation for Economic Co-operation and Development.

Abstract:

This method provides information on health hazard likely to arise from short-term exposure to a test article (gas, vapour or aerosol/particulate test article) by inhalation. The revised Test Guideline describes two studies: a traditional LC50 protocol and a Concentration x Time (C x t) protocol. It can be used to estimate a median lethal concentration (LC50), non-lethal threshold concentration (LC01) and slope, and to identify possible sex susceptibility. This Test Guideline enables a test article quantitative risk assessment and classification according to the Globally Harmonized System for the Classification and Labelling of Chemicals. In the traditional LC50 protocol, animals are exposed to one limit concentration or to three concentrations, at least, for a predetermined duration, generally of 4 hours. Usually 10 animals should be used for each concentration. In the C x T protocol, animals are exposed to one limit concentration or a series of concentrations over multiple time durations. Usually 2 animals per C x t interval are used. Animals (the preferred species is the rat) should be observed for at least 14 days. The study includes measurements (including weighing), daily and detailed observations, as well as gross necropsy.

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