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Adeno-associated virus : methods and protocols

Author: Richard O Snyder; Philippe Moullier
Publisher: Totowa, NJ : Humana Press, ©2011.
Series: Methods in molecular biology (Clifton, N.J.), v. 807.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Today, progress in rAAV-mediated gene transfer is so robust that long-term, efficient, and regulatable transgene expression is reproducibly achieved in large animal models. The complexity of gene transfer agents in the context of their clinical use requires investigators from a wide variety of backgrounds to have an understanding -- or at least an appreciation of -- the regulatory environment and constraints that  Read more...
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Genre/Form: Laboratory manuals
Electronic books
Laboratory Manuals
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Richard O Snyder; Philippe Moullier
ISBN: 9781617793707 1617793701 1617793698 9781617793691
OCLC Number: 760084366
Language Note: English.
Description: 1 online resource (xiii, 462 pages).
Contents: Adeno-associated virus biology / Matthew D. Weitzman and R. Michael Linden --
Design and construction of functional AAV vectors / John T. Gray and Serge Zolotukhin --
AAV capsid structure and cell interactions / Mavis Agbandje-McKenna and Jürgen Kleinschmidt --
Exploring natural diversity of AAV for the design of vectors with novel properties / Guangping Gao, Li Zhong, and Olivier Danos --
Gene therapy in skeletal muscle mediated by adeno-associated virus vectors / Chunping Qiao [and others] --
AAV mediated liver-directed gene therapy / Mark S. Sands --
Recombinant AAV delivery to the central nervous system / Olivier Bockstael [and others] --
Adeno-associated virus mediated gene therapy for retinal degenerative diseases / Knut Steiger [and others] --
Adeno-associated virus vector delivery to the heart / Lawrence T. Bish [and others] --
Evaluation of the fate of rAAV genomes following in vivo administration / K. Reed Clark and Magalie Penaud-Budloo --
Measuring immune responses to recombinant AAV gene transfer / Ashley T. Martino [and others] --
Modificaton and labeling of AAV vector particles / Hildegard Büning [and others] --
AAV mediated gene targeting / Daniel G. Miller --
Preclinical study design for rAAV / Terence R. Flotte, Thomas J. Conlon, and Christian Mueller --
Biodistribution and shedding of AAV vectors / Caroline Le Guiner, Phillipe Moullier, and Valder R. Arruda --
Production and purification of recombinant adeno-associated vectors / Lijun Wang [and others] --
rAAV vector product characterization and stability studies / Richard O. Snyder, Muriel Audit, and Joyce D. Francis --
rAAV human trial experience / Katherine A. High and Patrick Aubourg.
Series Title: Methods in molecular biology (Clifton, N.J.), v. 807.
Responsibility: edited by Richard O. Snyder, Philippe Moullier.

Abstract:

Progress in rAAV-mediated gene transfer is so robust that long-term, efficient, and regulatable transgene expression is reproducibly achieved in large animal models. This book provides a complete and  Read more...

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