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Adenoviral vectors for gene therapy

Author: David Curiel; Joanne T Douglas
Publisher: Amsterdam ; Boston : Academic Press, ©2002.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Adenoviral vectors for gene therapy.
Amsterdam ; Boston : Academic Press, ©2002
(DLC) 2001098272
(OCoLC)49780706
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: David Curiel; Joanne T Douglas
ISBN: 9781435632004 1435632001 9780080525969 0080525962
OCLC Number: 162129420
Description: 1 online resource (xxviii, 677 pages) : illustrations
Contents: Adenovirus Structure --
Biology of Adenovirus Cell Entry --
Adenovirus Replication --
Adenoviral Vector Construction I: Mammalian Systems --
Adenoviral Vector Construction II: Bacterial Systems --
Propagation of Adenoviral Vectors: Use of PER. C6 Cells --
Purification of Adenovirus --
Targeted Adenoviral Vectors I: Transductional Targeting --
Targeted Adenoviral Vectors II: Transcriptional Targeting --
Development of Attenuated Replication Competent Adenoviruses ARCAs) for the treatment of Prostate Cancer --
Replication-Selective Oncolytic Adenovirus EI-Region Mutants: Virotherapy for Cancer --
Innate Immune Responses to in Vivo Adenovirus Infection --
Humoral Immune Response --
Novel Methods to Eliminate the Immune Response to Adenovirus Gene Therapy --
High-Capacity "Gutless" Adenoviral Vectors: Technical Aspects and Applications --
Xenogenic Adenoviral Vectors --
Hybrid Adenoviral Vectors --
Utility of Adenoviral Vectors in Animal Models of Human Disease I: Cancer --
Utiltity of Adenoviral Vectors in Animal Models of Human Disease II: Genetic Disease --
Utility of Adenoviral Vectors in Animal Models of Human Disease III: Acquired Diseases --
Testing of Adenoviral Vector Gene Transfer Products: FDA Expectations --
Imaging Adenovirus-Medicated Gene Transfer.
Responsibility: edited by David T. Curiel, Joanne T. Douglas.
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Covers topics that range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, vectorology and the use of adenoviral vectors in preclinical animal  Read more...

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"This is a well organized collection of reviews written by authorities in the field that covers key aspects in the use of adenovirus as a gene transfer vehicle. The complete coverage of so many Read more...

 
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