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Adenoviral vectors for gene therapy

Author: David Curiel; Joanne T Douglas
Publisher: Amsterdam ; Boston : Academic Press, ©2002.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:

Covers topics that range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, vectorology and the use of adenoviral vectors in preclinical animal  Read more...

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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: David Curiel; Joanne T Douglas
ISBN: 0121995046 9780121995041
OCLC Number: 49780706
Description: xxviii, 677 pages : illustrations ; 24 cm
Contents: Adenovirus structure / Phoebe L. Stewart --
Biology of adenovirus cell entry / Glen R. Nemerow --
Adenovirus replication / Jared D. Evans --
Adenoviral vector construction I: mammalian systems / Philip Ng --
Adenoviral vector construction II: bacterial systems / M. Lusky --
Propagation of adenoviral vectors: use of PER. C6 cells / W.W. Nichols --
Purification of adenovirus / Paul Shabram --
Targeted adenoviral vectors I: transductional targeting / Victor Krasnykh --
Targeted adenoviral vectors II: transcriptional targeting / Sudhanshu P. Raikwar --
Development of attenuated replication competent adenoviruses (ARCAs) for the treatment of prostate cancer / Daniel R. Henderson --
Replication-selective oncolytic adenovirus E1-region mutants: virotherapy for cancer / David Kirn --
Innate immune responses to in vivo adenovirus infection / Bruce C. Trapnell --
Humoral immune response / Catherine O'Riordan --
Novel methods to eliminate the immune response to adenovirus gene therapy / Huang-Ge Zhang --
High-capacity "gutless" adenoviral vectors: technical aspects and applications / Gudrun Schiedner --
Xenogenic adenoviral vectors / Gerald W. Both --
Hybrid Adenoviral vectors / Stephen J. Murphy --
Utility of adenoviral vectors in animal models of human disease I: cancer / Raj K. Batra --
Utility of adenoviral vectors in animal models of human disease II: genetic disease / Raymond John Pickles --
Utility of adenoviral vectors in animal models of human disease III: acquired diseases / Erik Lubberts --
Testing of adenoviral vector gene transfer products: FDA expectations / Steven R. Bauer --
Imaging adenovirus-mediated gene transfer / Kurt R. Zinn.
Responsibility: edited by David T. Curiel, Joanne T. Douglas.
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"This is a well organized collection of reviews written by authorities in the field that covers key aspects in the use of adenovirus as a gene transfer vehicle. The complete coverage of so many Read more...

 
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