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Adherens junctions : from molecular mechanisms to tissue development and disease

Author: Tony Harris
Publisher: Dordrecht ; New York : Springer, ©2012.
Series: Sub-cellular biochemistry, 60.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Cell-cell adhesion is fundamental for the development and homeostasis of animal tissues and organs.¡ Adherens junctions (AJs) are the best understood cell-cell adhesion complexes.¡ In this volume, internationally recognized experts review AJ biology over a wide range of organization; from atoms to molecules, to protein complexes, molecular networks, cells, tissues, and overall animal development.¡ AJs have also been  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Tony Harris
ISBN: 9789400741867 9400741863
OCLC Number: 795781476
Description: 1 online resource.
Contents: An Introduction to Adherens Junctions: From Molecular Mechanisms to Tissue Development and Disease / Tony J.C. Harris --
Part 1. How AJs evolved. --
Evolution of the Cadherin-Catenin Complex / Oda Hiroki --
Part 2. How cadherins and catenins interact to assemble AJs. --
The Three-Dimensional Structure of the Cadherin-Catenin Complex / Noboru Ishiyama and Mitsuhiko Ikura --
Biophysics of Cadherin Adhesion / Deborah Leckband and Sanjeevi Sivasankar --
Adherens Junction Assembly / Sergey Troyanovsky --
Part 3. How AJs interface with other cellular machinery. --
The Cytoskeleton and Classical Cadherin Adhesions / Siew Ping Han and Alpha S. Yap --
Immunoglobulin Superfamily Receptors and Adherens Junctions / Yohei Shimono, Yoshiyuki Rikitake, Kenji Mandai, Masahiro Mori and Yoshimi Takai --
Signaling from the Adherens Junction / Abbye E. McEwen, David E. Escobar and Cara J. Gottardi --
Adherens Junction Turnover: Regulating Adhesion Through Cadherin Endocytosis, Degradation, and Recycling / Andrew P. Kowalczyk and Benjamin A. Nanes --
Part 4. How AJs affect cell behaviour and multicellular development. --
Adherens Junctions During Cell Migration / Sandrine Etienne-Manneville --
Adherens Junctions and Cadherins in Drosophila Development / Annalisa Letizia and Marta Llimargas --
Adherens Junctions in C. elegans Embryonic Morphogenesis / Stephen T. Armenti and Jeremy Nance --
Cadherin Function During Xenopus Gastrulation / Rudolf Winklbauer --
Adherens Junctions in Mammalian Development, Homeostasis and Disease: Lessons from Mice / Barbara Boggetti and Carien M. Niessen --
Part 5. How AJs affect tissue homeostasis and disease. --
Adherens Junctions and Stem Cells / Terry Lechler --
Adherens Junctions and Cancer / Valeri Vasioukhin --
Adherens Junctions and Pathogen Entry / Georgios Nikitas and Pascale Cossart.
Series Title: Sub-cellular biochemistry, 60.
Responsibility: Tony Harris, editor.

Abstract:

Cell-cell adhesion is fundamental for the development and homeostasis of animal tissues and organs.¡ Adherens junctions (AJs) are the best understood cell-cell adhesion complexes.¡ In this volume, internationally recognized experts review AJ biology over a wide range of organization; from atoms to molecules, to protein complexes, molecular networks, cells, tissues, and overall animal development.¡ AJs have also been an integral part of animal evolution, and play central roles in cancer development, pathogen infection and other diseases.¡ This book addresses major questions encompassing AJ biology. - How did AJs evolve? - How do cadherins and catenins interact to assemble AJs and mediate adhesion? - How do AJs interface with other cellular machinery to couple adhesion with the whole cell? - How do AJs affect cell behaviour and multicellular development? - How can abnormal AJ activity lead to disease? Valuable for both newcomers and experts in the field, this book offers a comprehensive resource for the research laboratory and a teaching tool for advanced undergraduate and graduate courses in cell and developmental biology.

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