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Adipose Tissue and Cancer

Author: Mikhail G Kolonin
Publisher: Dordrecht : Springer, 2013.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Recent studies have shown that cells from adipose tissue are capable of trafficking to tumors, thus enabling paracrine action of adipokines from within the tumor microenvironment. Increased tumor vascularization, immune system suppression and direct effects on malignant cell survival and proliferation have been investigated as mechanisms regulated by adipokines. The goal of this book is to discuss data pointing to  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Kolonin, Mikhail G.
Adipose Tissue and Cancer.
Dordrecht : Springer, ©2013
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Mikhail G Kolonin
ISBN: 9781461476603 1461476607
OCLC Number: 858763677
Notes: Thyroid Cancer.
Description: 1 online resource (193 pages)
Contents: Preface; Contents; Chapter 1: Metabolic Perturbations Associated with Adipose Tissue Dysfunction and the Obesity-Cancer Link; 1.1 Introduction; 1.2 Obesity and Adipose Tissue Dysfunction and Remodeling; 1.2.1 Adipose Tissue Function; 1.2.2 Hypoxia and Inflammation; 1.2.3 Ectopic Fat and Adipose Tissue Dysfunction; 1.3 Obesity and Metabolic Perturbations; 1.3.1 Dysregulated Growth Signals; Insulin and IGF-1; Signaling Pathways Downstream of the Insulin Receptor and IGF-1R; Leptin, Adiponectin, and the Leptin-to-Adiponectin Ratio; 1.3.2 Chronic Inflammation. Cytokines and Crosstalk Between Adipocytes, Macrophages, and Epithelial CellsInflammation and Cancer; 1.3.3 Changes in Vascular Integrity Factors; Vascular Endothelial Growth Factor; PAI-1; 1.4 Conclusion; References; Chapter 2: Increased Adiposity and Colorectal Cancer; 2.1 Introduction; 2.2 Anthropometric Measurements and Colon Cancer; 2.3 Colon Cancer Location; 2.4 Obesity, Physical Activity, and Colon Cancer; 2.5 Adipose Progenitor Cells; 2.6 Adipocytokines and Adipose Tissue Inflammation: Driving Forces of Colonic Carcinogenesis. 2.6.1 Adipose Tissue: A "Sink" of Tumor-Promoting Mediators?2.6.2 JNK: Another Pathway in Obesity-Related Colorectal Carcinoma?; 2.7 Nonalcoholic Fatty Liver Disease and Increased Colon Carcinogenesis; References; Chapter 3: Adiposity and Diabetes in Breast and Prostate Cancer; 3.1 Introduction; 3.2 Breast Cancer; 3.3 Obesity and Breast Cancer Risk; 3.3.1 Premenopause; 3.3.2 Postmenopause; 3.4 Obesity and Breast Cancer Prognosis; 3.5 Upper Versus Lower Body Obesity and Breast Cancer Risk; 3.6 Type 2 Diabetes and Breast Cancer Risk and Prognosis; 3.6.1 Obesity-Related Variables. 3.6.2 Insulin-Related Variables3.7 Prostate Cancer; 3.7.1 Obesity; 3.7.2 Diabetes; 3.8 Mechanisms; 3.8.1 Sex Steroid Hormones; 3.8.2 Adipokines; 3.8.3 Insulin; 3.9 Concluding Remarks; References; Chapter 4: Increased Adiposity and Endometrial Cancer Risk; 4.1 Introduction; 4.2 Epidemiology; 4.2.1 Endometrial Cancer Incidence; Body Mass Index; Visceral Adiposity; 4.2.2 Endometrial Cancer Mortality; 4.3 Mechanisms Through Which Adiposity Promotes Endometrial Cancer Initiation and Progression; 4.3.1 Estrogen; 4.3.2 Adipokines; 4.3.3 Inflammation; 4.3.4 Insulin/IGF-1; 4.3.5 Cellular Metabolism. 4.3.6 Adipose Stem Cells4.4 Interventions for Cancer Prevention; 4.4.1 Behavioral Interventions: Diet and Physical Activity; 4.4.2 Pharmaceutical Intervention; Contraceptives; Metformin (Antidiabetic Agents); 4.4.3 Surgical Intervention: Bariatric Surgery; 4.5 Future Directions; References; Chapter 5: Adipokines: Soluble Factors from Adipose Tissue Implicated in Cancer; 5.1 Introduction; 5.2 Epidemiology of Obesity-Related Cancer; 5.3 Pathophysiology of Obesity; 5.4 Pathophysiological Bases of Obesity-Related Cancer; 5.4.1 Adipokines; Leptin; Prostate Cancer; Breast Cancer; Colorectal Cancer.

Abstract:

Recent studies have shown that cells from adipose tissue are capable of trafficking to tumors, thus enabling paracrine action of adipokines from within the tumor microenvironment. Increased tumor vascularization, immune system suppression and direct effects on malignant cell survival and proliferation have been investigated as mechanisms regulated by adipokines. The goal of this book is to discuss data pointing to the role of adipose tissue in cancer and to dissect individual mechanisms through which adipose tissue excess or restriction could influence cancer progression.

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